|
Drug Target 1
[top]
|
| Target 1 ID |
1050 |
| Target 1 Name |
Bile salt sulfotransferase |
| Target 1 Synonyms |
- DHEA-ST
- Dehydroepiandrosterone sulfotransferase
- EC 2.8.2.14
- HST
- Hydroxysteroid Sulfotransferase
- ST2
- ST2A3
|
| Target 1 Gene Name |
SULT2A1 |
| Target 1 Protein Sequence |
>Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
|
| Target 1 Number of Residues |
289 |
| Target 1 Molecular Weight |
33780 |
| Target 1 Theoretical pI |
5.76 |
| Target 1 GO Classification |
|
Function
|
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 1 General Function |
Involved in sulfotransferase activity |
| Target 1 Specific Function |
Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands |
| Target 1 Pathways |
Not Available
|
| Target 1 Reactions |
- (1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
|
| Target 1 Pfam Domain Function |
|
| Target 1 Signals |
|
| Target 1 Transmembrane Regions |
|
| Target 1 Essentiality |
Non-Essential |
| Target 1 GenBank ID Protein |
306702  |
| Target 1 UniProtKB/Swiss-Prot ID |
Q06520  |
| Target 1 UniProtKB/Swiss-Prot Entry Name |
ST2A1_HUMAN  |
| Target 1 PDB ID |
1OV4  |
| Target 1 PDB File |
Show |
| Target 1 3D Structure |
|
| Target 1 Cellular Location |
|
| Target 1 Gene Sequence |
>858 bp
ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATCC
GAAACCTTAAGAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATATTG
ACTTACCCCAAATCAGGAACAAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCCAAG
GGGGATGCCAAGTGGATCCAATCTGTGCCCATCTGGGAGCGATCACCCTGGGTAGAGAGT
GAGATTGGGTATACAGCACTCAGTGAAAGCGAGAGTCCACGTTTATTCTCCTCCCACCTC
CCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGATTTATCTCATG
AGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAGTTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGTGCTATAT
GGGTCATGGTTTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAAACTTCCTG
TTACTGAGTTATGAGGAGCTGAAACAGGACACAGGAAGAACCATAGAGAAGATCTGTCAA
TTCCTGGGAAAGACGTTAGAACCCGAAGAACTGAACTTAATTCTCAAGAACAGCTCCTTT
CAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCCTGAGTGTTGATTATGTAGTG
GACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATCACTTCACAGTG
GCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGATCTTCCTCGAGAG
CTGTTCCCATGGGAATAA
|
| Target 1 GenBank Gene ID |
|
| Target 1 GeneCard ID |
SULT2A1  |
| Target 1 GenAtlas ID |
SULT2A1  |
| Target 1 HGNC ID |
HGNC:11458  |
| Target 1 Chromosome Location |
19 |
| Target 1 Locus |
19q13.3 |
| Target 1 SNPs |
SNPJam Report  |
| Target 1 General References |
- Kong AN, Yang L, Ma M, Tao D, Bjornsson TD: Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. Biochem Biophys Res Commun. 1992 Aug 31;187(1):448-54. [PubMed
]
- Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM: Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. Mol Pharmacol. 1992 May;41(5):865-72. [PubMed
]
- Forbes KJ, Hagen M, Glatt H, Hume R, Coughtrie MW: Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. Mol Cell Endocrinol. 1995 Jul;112(1):53-60. [PubMed
]
- Luu-The V, Dufort I, Paquet N, Reimnitz G, Labrie F: Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. DNA Cell Biol. 1995 Jun;14(6):511-8. [PubMed
]
- Comer KA, Falany JL, Falany CN: Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. Biochem J. 1993 Jan 1;289 ( Pt 1):233-40. [PubMed
]
- Otterness DM, Her C, Aksoy S, Kimura S, Wieben ED, Weinshilboum RM: Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization. DNA Cell Biol. 1995 Apr;14(4):331-41. [PubMed
]
|
| Target 1 Drug References |
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed
]
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed
]
|
|
Drug Target 2
[top]
|
| Target 2 ID |
3059 |
| Target 2 Name |
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| Target 2 Synonyms |
- EC 1.1.1.53
|
| Target 2 Gene Name |
fabG3 |
| Target 2 Protein Sequence |
>3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVHL
DVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGI
RAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNS
IHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVA
GLAHNDFGAVEVSSQPEWVT
|
| Target 2 Number of Residues |
264 |
| Target 2 Molecular Weight |
27030 |
| Target 2 Theoretical pI |
4.79 |
| Target 2 GO Classification |
|
Function
|
catalytic activity
oxidoreductase activity |
|
Process
|
physiological process
metabolism |
|
Component
|
| Not Available |
|
| Target 2 General Function |
Lipid transport and metabolism |
| Target 2 Specific Function |
Androstan-3-alpha,17-beta-diol + NAD(+) = 17- beta-hydroxyandrostan-3-one + NADH |
| Target 2 Pathways |
|
| Target 2 Reactions |
- androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+
|
| Target 2 Pfam Domain Function |
|
| Target 2 Signals |
|
| Target 2 Transmembrane Regions |
|
| Target 2 Essentiality |
Essential |
| Target 2 GenBank ID Protein |
3261591  |
| Target 2 UniProtKB/Swiss-Prot ID |
P69167  |
| Target 2 UniProtKB/Swiss-Prot Entry Name |
HSD_MYCTU  |
| Target 2 PDB ID |
1NFQ  |
| Target 2 PDB File |
Show |
| Target 2 3D Structure |
|
| Target 2 Cellular Location |
Not Available |
| Target 2 Gene Sequence |
>783 bp
ATGTCTGGACGGTTGATAGGAAAGGTCGCACTTGTCAGCGGCGGGGCGCGCGGTATGGGT
GCATCCCATGTGCGGGCGATGGTGGCCGAAGGCGCAAAGGTTGTGTTCGGCGACATCCTC
GACGAGGAGGGCAAGGCGGTGGCCGCCGAACTGGCCGATGCGGCCCGCTACGTCCATCTC
GACGTTACCCAACCCGCGCAATGGACGGCTGCGGTGGACACCGCGGTCACCGCATTCGGT
GGCCTGCACGTGCTGGTCAACAACGCCGGCATTCTCAACATCGGGACGATCGAGGACTAC
GCCCTCACCGAATGGCAGCGCATCCTCGATGTCAACCTGACCGGAGTCTTCCTGGGCATC
CGCGCTGTCGTCAAGCCAATGAAAGAGGCTGGTCGCGGCTCCATCATCAACATTTCGTCG
ATCGAGGGGCTGGCCGGCACGGTTGCTTGTCATGGCTATACCGCCACCAAGTTCGCCGTG
CGGGGGCTGACCAAGTCCACCGCTCTCGAGTTGGGGCCCAGCGGAATTCGAGTCAACTCG
ATTCACCCTGGGTTGGTCAAGACGCCGATGACTGACTGGGTCCCCGAAGACATCTTCCAG
ACCGCGCTGGGCCGCGCGGCCGAACCCGTGGAAGTGTCCAACCTCGTCGTCTACCTGGCC
AGCGATGAGTCGAGCTATTCCACCGGCGCGGAATTTGTGGTCGACGGCGGGACCGTAGCT
GGCCTGGCACACAACGACTTCGGTGCCGTCGAGGTGTCCTCGCAGCCGGAATGGGTGACG
TAA
|
| Target 2 GenBank Gene ID |
|
| Target 2 GeneCard ID |
Not Available |
| Target 2 GenAtlas ID |
Not Available |
| Target 2 HGNC ID |
Not Available |
| Target 2 Chromosome Location |
Not Available |
| Target 2 Locus |
Not Available |
| Target 2 SNPs |
SNPJam Report  |
| Target 2 General References |
- Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM: Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol. 2002 Oct;184(19):5479-90. [PubMed
]
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [PubMed
]
|
| Target 2 Drug References |
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed
]
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed
]
|
|
Drug Target 3
[top]
|
| Target 3 ID |
4379 |
| Target 3 Name |
Retinol dehydratase |
| Target 3 Synonyms |
Not Available |
| Target 3 Gene Name |
Not Available |
| Target 3 Protein Sequence |
>Retinol dehydratase
MEKQQDLPFPYEFRELNPEEDKLVKANLGAFPTTYVKLGPKGYMVYRPYLKDAANIYNMP
LRPTDVFVASYQRSGTTMTQELVWLIENDLNFEAAKTYMSLRYIYLDGFMIYDPEKQEEY
NDILPNPENLDMERYLGLLEYFSRPGSSLLAAVPPTEKRFVKTHLPLSLMPPNMLDTVKM
VYLARDPRDVAVSSFHHARLLYLLNKQSNFKDFWEMFHRGLYTLTPYFEHVKEAWAKRHD
PNMLFLFYEDYLKDLPGCIARIADFLGKKLSEEQIQRLCEHLNFEKFKNNGAVNMEDYRE
IGILADGEHFIRKGKAGCWRDYFDEEMTKQAEKWIKDNLKDTDLRYPNMEL
|
| Target 3 Number of Residues |
356 |
| Target 3 Molecular Weight |
41563 |
| Target 3 Theoretical pI |
5.50 |
| Target 3 GO Classification |
|
Function
|
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 3 General Function |
Involved in sulfotransferase activity |
| Target 3 Specific Function |
Not Available |
| Target 3 Pathways |
Not Available
|
| Target 3 Reactions |
Not Available |
| Target 3 Pfam Domain Function |
|
| Target 3 Signals |
|
| Target 3 Transmembrane Regions |
|
| Target 3 Essentiality |
Essential |
| Target 3 GenBank ID Protein |
Not Available |
| Target 3 UniProtKB/Swiss-Prot ID |
Q26490  |
| Target 3 UniProtKB/Swiss-Prot Entry Name |
Q26490_SPOFR  |
| Target 3 PDB ID |
1FML  |
| Target 3 PDB File |
Show |
| Target 3 3D Structure |
|
| Target 3 Cellular Location |
Not Available |
| Target 3 Gene Sequence |
>1056 bp
ATGGAGAAACAACAGGATTTGCCATTCCCTTACGAGTTTAGGGAGCTTAACCCCGAAGAA
GATAAATTGGTTAAAGCCAATTTAGGCGCGTTCCCCACAACCTACGTGAAACTGGGGCCT
AAAGGCTACATGGTGTACAGACCCTACTTGAAAGATGCGGCGAATATCTACAACATGCCT
CTAAGACCTACAGACGTGTTCGTTGCCAGTTATCAACGATCAGGAACGACAATGACTCAA
GAACTAGTTTGGCTAATTGAAAACGACTTGAATTTCGAAGCTGCAAAAACATACATGTCC
CTCCGCTACATTTATCTTGACGGCTTCATGATCTACGACCCGGAGAAGCAAGAAGAATAT
AACGACATATTACCAAATCCAGAAAACCTTGATATGGAAAGGTATTTAGGATTGCTAGAA
TACTTTAGTCGTCCAGGGAGCTCATTGCTCGCTGCAGTGCCACCGACAGAGAAAAGATTT
GTGAAGACCCACTTGCCTTTGTCCTTGATGCCTCCCAATATGTTGGATACTGTGAAGATG
GTGTACCTGGCTCGAGACCCTAGAGACGTGGCGGTGTCCAGCTTCCACCACGCCCGGTTA
TTGTATTTGCTGAATAAGCAGAGCAACTTCAAAGATTTCTGGGAAATGTTTCACCGTGGC
CTATATACGCTGACACCATATTTCGAGCACGTCAAGGAAGCTTGGGCAAAGAGACATGAT
CCGAACATGCTGTTTTTGTTTTACGAAGACTACTTAAAGGACTTACCAGGCTGCATTGCA
CGTATCGCTGACTTCTTGGGCAAGAAGTTGAGTGAGGAACAAATTCAGCGCCTCTGCGAA
CACCTGAATTTCGAAAAGTTCAAAAACAATGGCGCTGTCAATATGGAGGACTACAGGGAA
ATTGGAATACTCGCTGACGGGGAGCATTTCATTAGAAAAGGTAAAGCAGGATGCTGGCGC
GACTACTTCGACGAGGAGATGACGAAACAAGCTGAGAAATGGATCAAGGACAACCTGAAG
GATACTGATCTGCGCTACCCAAATATGGAATTATAA
|
| Target 3 GenBank Gene ID |
|
| Target 3 GeneCard ID |
Not Available |
| Target 3 GenAtlas ID |
Not Available |
| Target 3 HGNC ID |
Not Available |
| Target 3 Chromosome Location |
Not Available |
| Target 3 Locus |
Not Available |
| Target 3 SNPs |
Not Available |
| Target 3 General References |
- Pakhomova S, Kobayashi M, Buck J, Newcomer ME: A helical lid converts a sulfotransferase to a dehydratase. Nat Struct Biol. 2001 May;8(5):447-51. [PubMed
]
- Komatsu K, Driscoll WJ, Koh YC, Strott CA: A P-loop related motif (GxxGxxK) highly conserved in sulfotransferases is required for binding the activated sulfate donor. Biochem Biophys Res Commun. 1994 Nov 15;204(3):1178-85. [PubMed
]
- Zheng Y, Bergold A, Duffel MW: Affinity labeling of aryl sulfotransferase IV. Identification of a peptide sequence at the binding site for 3'-phosphoadenosine-5'-phosphosulfate. J Biol Chem. 1994 Dec 2;269(48):30313-9. [PubMed
]
- Grun F, Noy N, Hammerling U, Buck J: Purification, cloning, and bacterial expression of retinol dehydratase from Spodoptera frugiperda. J Biol Chem. 1996 Jul 5;271(27):16135-8. [PubMed
]
|
| Target 3 Drug References |
Not Available |
|
Drug Target 4
[top]
|
| Target 4 ID |
4824 |
| Target 4 Name |
Dehydrogenase/reductase SDR family member 8 |
| Target 4 Synonyms |
- 17-beta- HSD XI
- 17-beta-HSD 11
- 17-beta-hydroxysteroid dehydrogenase 11
- 17bHSD11
- 17betaHSD11
- 17betaHSDXI
- CTCL tumor antigen HD-CL-03
- Cutaneous T-cell lymphoma- associated antigen HD-CL-03
- Dehydrogenase/reductase SDR family member 8 precursor
- EC 1.1.1.-
- Retinal short-chain dehydrogenase/reductase 2
- retSDR2
|
| Target 4 Gene Name |
DHRS8 |
| Target 4 Protein Sequence |
>Dehydrogenase/reductase SDR family member 8
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK
SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN
AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP
FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE
EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKRKISVKFDAVIGYKMKAQ
|
| Target 4 Number of Residues |
305 |
| Target 4 Molecular Weight |
32964 |
| Target 4 Theoretical pI |
9.70 |
| Target 4 GO Classification |
|
Function
|
catalytic activity
oxidoreductase activity |
|
Process
|
physiological process
metabolism |
|
Component
|
| Not Available |
|
| Target 4 General Function |
Involved in oxidoreductase activity |
| Target 4 Specific Function |
Can convert androstan-3-alpha,17-beta-diol (3alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma |
| Target 4 Pathways |
Not Available
|
| Target 4 Reactions |
Not Available |
| Target 4 Pfam Domain Function |
|
| Target 4 Signals |
|
| Target 4 Transmembrane Regions |
|
| Target 4 Essentiality |
Non Essential |
| Target 4 GenBank ID Protein |
Not Available |
| Target 4 UniProtKB/Swiss-Prot ID |
Q8NBQ5  |
| Target 4 UniProtKB/Swiss-Prot Entry Name |
DHRS8_HUMAN  |
| Target 4 PDB ID |
1YB1  |
| Target 4 PDB File |
Show |
| Target 4 3D Structure |
|
| Target 4 Cellular Location |
- Secreted protein (Potential)
|
| Target 4 Gene Sequence |
>903 bp
ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAG
TCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTG
ATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA
AGCAAGCTGGTTCTCTGGGATATAAATAAGCATGGACTGGAGGAAACAGCTGCCAAATGC
AAGGGACTGGGTGCCAAGGTTCATACCTTTGTGGTAGACTGCAGCAACCGAGAAGATATT
TACAGCTCTGCAAAGAAGGTGAAGGCAGAAATTGGAGATGTTAGTATTTTAGTAAATAAT
GCTGGTGTAGTCTATACATCAGATTTGTTTGCTACACAAGATCCTCAGATTGAAAAGACT
TTTGAAGTTAATGTACTTGCACATTTCTGGACTACAAAGGCATTTCTTCCTGCAATGACG
AAGAATAACCATGGCCATATTGTCACTGTGGCTTCGGCAGCTGGACATGTCTCGGTCCCC
TTCTTACTGGCTTACTGTTCAAGCAAGTTTGCTGCTGTTGGATTTCATAAAACTTTGACA
GATGAACTGGCTGCCTTACAAATAACTGGAGTCAAAACAACATGTCTGTGTCCTAATTTC
GTAAACACTGGCTTCATCAAAAATCCAAGTACAAGTTTGGGACCCACTCTGGAACCCGAG
GAAGTGGTAAACAGGCTGATGCATGGGATTCTGACTGAGCAGAAGATGATTTTTATTCCA
TCTTCTATAGCTTTTTTAACAACATTGGAAAGGATCCTTCCTGAGCGTTTCCTGGCAGTT
TTAAAACGAAAAATCAGTGTTAAGTTTGATGCAGTTATTGGATATAAAATGAAAGCGCAA
TAA
|
| Target 4 GenBank Gene ID |
|
| Target 4 GeneCard ID |
Not Available |
| Target 4 GenAtlas ID |
HSD17B11  |
| Target 4 HGNC ID |
HGNC:22960  |
| Target 4 Chromosome Location |
4 |
| Target 4 Locus |
4q22.1 |
| Target 4 SNPs |
SNPJam Report  |
| Target 4 General References |
- Haeseleer F, Palczewski K: Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000;316:372-83. [PubMed
]
- Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z: Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22;171(1-2):111-7. [PubMed
]
- Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z: 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. Endocrinology. 2003 May;144(5):2084-91. [PubMed
]
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed
]
- Li KX, Smith RE, Krozowski ZS: Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase. Endocr Res. 1998 Aug-Nov;24(3-4):663-7. [PubMed
]
|
| Target 4 Drug References |
Not Available |