You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameCamptothecin
Accession NumberDB04690
TypeSmall Molecule
GroupsExperimental
DescriptionAn alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. [PubChem]
Structure
Thumb
Synonyms
(+)-camptothecin
(+)-camptothecine
(s)-(+)-camptothecin
(s)-camptothecin
20(S)-Camptothecin
21,22-Secocamptothecin-21-oic acid lactone
Camptothecine
D-camptothecin
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIXT3Z54Z28A
CAS number7689-03-4
WeightAverage: 348.352
Monoisotopic: 348.11100701
Chemical FormulaC20H16N2O4
InChI KeyInChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N
InChI
InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
IUPAC Name
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
SMILES
CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=CC=CC=C4N=C13)C2=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring).
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassCamptothecins
Sub ClassNot Available
Direct ParentCamptothecins
Alternative Parents
Substituents
  • Camptothecin
  • Quinoline
  • Pyranopyridine
  • Pyridinone
  • Benzenoid
  • Pyridine
  • Heteroaromatic compound
  • Tertiary alcohol
  • Lactone
  • Lactam
  • Carboxylic acid ester
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationInvestigated for the treatment of cancer.
PharmacodynamicsCamptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.
Mechanism of actionCamptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it. This prevents DNA relegation and therefore causes DNA damage which results in apoptosis.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityAcute oral toxicity (LD50) in mouse: 50.1 mg/kg
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.841
Blood Brain Barrier-0.6345
Caco-2 permeable-0.5555
P-glycoprotein substrateSubstrate0.6039
P-glycoprotein inhibitor INon-inhibitor0.7852
P-glycoprotein inhibitor IINon-inhibitor0.9762
Renal organic cation transporterNon-inhibitor0.8376
CYP450 2C9 substrateNon-substrate0.8311
CYP450 2D6 substrateNon-substrate0.8454
CYP450 3A4 substrateSubstrate0.546
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9232
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5591
Ames testNon AMES toxic0.5393
CarcinogenicityNon-carcinogens0.8187
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.3261 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9939
hERG inhibition (predictor II)Non-inhibitor0.902
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point275-277 °CVolkmann
logP1.74HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.511 mg/mLALOGPS
logP1.91ALOGPS
logP1.22ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)11.71ChemAxon
pKa (Strongest Basic)3.07ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area79.73 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity94.49 m3·mol-1ChemAxon
Polarizability36.4 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Tadashi Miyasaka, Seigo Sawada, Kenichiro Nokata, Masahiko Mutai, “Photochemical process for preparing camptothecin derivatives.” U.S. Patent US4545880, issued March, 1976.

US4545880
General References
  1. Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4. [PubMed:9213622 ]
  2. Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8. [PubMed:5357525 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.9 KB)
Interactions
Drug Interactions
Drug
AcetaminophenThe serum concentration of Camptothecin can be increased when it is combined with Acetaminophen.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Camptothecin.
AfatinibThe serum concentration of Camptothecin can be increased when it is combined with Afatinib.
AlbendazoleThe serum concentration of Camptothecin can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Camptothecin can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Camptothecin can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Camptothecin can be increased when it is combined with Alfentanil.
AmantadineThe serum concentration of Camptothecin can be increased when it is combined with Amantadine.
Aminohippuric acidThe serum concentration of Camptothecin can be increased when it is combined with Aminohippuric acid.
AmiodaroneThe serum concentration of Camptothecin can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Camptothecin can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Camptothecin can be increased when it is combined with Amlodipine.
AmprenavirThe serum concentration of Camptothecin can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Camptothecin can be increased when it is combined with Amsacrine.
AstemizoleThe serum concentration of Camptothecin can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Camptothecin can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Camptothecin can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Camptothecin can be increased when it is combined with Atorvastatin.
AzelastineThe serum concentration of Camptothecin can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Camptothecin can be increased when it is combined with Azithromycin.
BenzocaineThe serum concentration of Camptothecin can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Camptothecin can be increased when it is combined with Bepridil.
BevacizumabBevacizumab may increase the cardiotoxic activities of Camptothecin.
BiperidenThe serum concentration of Camptothecin can be increased when it is combined with Biperiden.
BosutinibThe serum concentration of Camptothecin can be increased when it is combined with Bosutinib.
BromocriptineThe serum concentration of Camptothecin can be increased when it is combined with Bromocriptine.
BuprenorphineThe serum concentration of Camptothecin can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Camptothecin can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Camptothecin can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Camptothecin can be increased when it is combined with Caffeine.
CanagliflozinThe serum concentration of Camptothecin can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Camptothecin can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Camptothecin can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Camptothecin can be decreased when it is combined with Carbamazepine.
CarvedilolThe serum concentration of Camptothecin can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Camptothecin can be increased when it is combined with Caspofungin.
ChloroquineThe serum concentration of Camptothecin can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Camptothecin can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Camptothecin can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Camptothecin can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Camptothecin can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Camptothecin can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Camptothecin can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Camptothecin can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Camptothecin can be increased when it is combined with Ciprofloxacin.
CitalopramThe serum concentration of Camptothecin can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Camptothecin can be increased when it is combined with Clarithromycin.
ClofazimineThe serum concentration of Camptothecin can be increased when it is combined with Clofazimine.
ClomipramineThe serum concentration of Camptothecin can be increased when it is combined with Clomipramine.
ClotrimazoleThe serum concentration of Camptothecin can be decreased when it is combined with Clotrimazole.
CobicistatThe serum concentration of Camptothecin can be increased when it is combined with Cobicistat.
ColchicineThe serum concentration of Camptothecin can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Camptothecin can be increased when it is combined with Colforsin.
CrizotinibThe serum concentration of Camptothecin can be increased when it is combined with Crizotinib.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Camptothecin.
CyclosporineThe serum concentration of Camptothecin can be decreased when it is combined with Cyclosporine.
DaclatasvirThe serum concentration of Camptothecin can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Camptothecin can be increased when it is combined with Dactinomycin.
DasatinibThe serum concentration of Camptothecin can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Camptothecin can be decreased when it is combined with Daunorubicin.
DesipramineThe serum concentration of Camptothecin can be increased when it is combined with Desipramine.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Camptothecin.
DesloratadineThe serum concentration of Camptothecin can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Camptothecin can be decreased when it is combined with Dexamethasone.
DextromethorphanThe serum concentration of Camptothecin can be increased when it is combined with Dextromethorphan.
DiclofenacThe serum concentration of Camptothecin can be increased when it is combined with Diclofenac.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Camptothecin.
DigoxinDigoxin may decrease the cardiotoxic activities of Camptothecin.
DihydroergotamineThe serum concentration of Camptothecin can be increased when it is combined with Dihydroergotamine.
DiltiazemThe serum concentration of Camptothecin can be increased when it is combined with Diltiazem.
DipyridamoleThe serum concentration of Camptothecin can be increased when it is combined with Dipyridamole.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Camptothecin.
DoxazosinThe serum concentration of Camptothecin can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Camptothecin can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Camptothecin can be decreased when it is combined with Doxorubicin.
DronabinolThe serum concentration of Camptothecin can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Camptothecin can be increased when it is combined with Dronedarone.
ElbasvirThe serum concentration of Camptothecin can be increased when it is combined with Elbasvir.
EltrombopagThe serum concentration of Camptothecin can be increased when it is combined with Eltrombopag.
EnalaprilThe serum concentration of Camptothecin can be increased when it is combined with Enalapril.
EnzalutamideThe serum concentration of Camptothecin can be increased when it is combined with Enzalutamide.
ErgonovineThe serum concentration of Camptothecin can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Camptothecin can be increased when it is combined with Ergotamine.
ErythromycinThe serum concentration of Camptothecin can be decreased when it is combined with Erythromycin.
EstramustineThe serum concentration of Camptothecin can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Camptothecin can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Camptothecin can be decreased when it is combined with Estrone.
EtoposideThe serum concentration of Camptothecin can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Camptothecin can be increased when it is combined with Etravirine.
FelodipineThe serum concentration of Camptothecin can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Camptothecin can be increased when it is combined with Fentanyl.
FexofenadineThe serum concentration of Camptothecin can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Camptothecin can be increased when it is combined with Fidaxomicin.
FluconazoleThe serum concentration of Camptothecin can be increased when it is combined with Fluconazole.
FluoxetineThe serum concentration of Camptothecin can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Camptothecin can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Camptothecin can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Camptothecin can be increased when it is combined with Flurazepam.
FluvoxamineThe serum concentration of Camptothecin can be increased when it is combined with Fluvoxamine.
GefitinibThe serum concentration of Camptothecin can be increased when it is combined with Gefitinib.
GenisteinThe serum concentration of Camptothecin can be increased when it is combined with Genistein.
GlyburideThe serum concentration of Camptothecin can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Camptothecin can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Camptothecin can be increased when it is combined with Gramicidin D.
GrepafloxacinThe serum concentration of Camptothecin can be increased when it is combined with Grepafloxacin.
HaloperidolThe serum concentration of Camptothecin can be increased when it is combined with Haloperidol.
HydrocortisoneThe serum concentration of Camptothecin can be increased when it is combined with Hydrocortisone.
IdelalisibThe serum concentration of Camptothecin can be increased when it is combined with Idelalisib.
ImatinibThe serum concentration of Camptothecin can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Camptothecin can be increased when it is combined with Imipramine.
IndinavirThe serum concentration of Camptothecin can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Camptothecin can be increased when it is combined with Indomethacin.
IsavuconazoniumThe serum concentration of Camptothecin can be increased when it is combined with Isavuconazonium.
ItraconazoleThe serum concentration of Camptothecin can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Camptothecin can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Camptothecin can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Camptothecin can be increased when it is combined with Ketamine.
KetoconazoleThe serum concentration of Camptothecin can be increased when it is combined with Ketoconazole.
LansoprazoleThe serum concentration of Camptothecin can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Camptothecin can be increased when it is combined with Lapatinib.
LevofloxacinThe serum concentration of Camptothecin can be increased when it is combined with Levofloxacin.
LevothyroxineThe serum concentration of Camptothecin can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Camptothecin can be increased when it is combined with Lidocaine.
LiothyronineThe serum concentration of Camptothecin can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Camptothecin can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Camptothecin can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Camptothecin can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Camptothecin can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Camptothecin can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Camptothecin can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Camptothecin can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Camptothecin can be increased when it is combined with Lovastatin.
LumacaftorThe serum concentration of Camptothecin can be decreased when it is combined with Lumacaftor.
MaprotilineThe serum concentration of Camptothecin can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Camptothecin can be increased when it is combined with Mebendazole.
MefloquineThe serum concentration of Camptothecin can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Camptothecin can be increased when it is combined with Megestrol acetate.
MeprobamateThe serum concentration of Camptothecin can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Camptothecin can be increased when it is combined with Methadone.
MetoprololThe serum concentration of Camptothecin can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Camptothecin can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Camptothecin can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Camptothecin can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Camptothecin can be decreased when it is combined with Mifepristone.
MitomycinThe serum concentration of Camptothecin can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Camptothecin can be decreased when it is combined with Mitoxantrone.
MorphineThe serum concentration of Camptothecin can be increased when it is combined with Morphine.
NaltrexoneThe serum concentration of Camptothecin can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Camptothecin can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Camptothecin can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Camptothecin can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Camptothecin can be increased when it is combined with Neostigmine.
NicardipineThe serum concentration of Camptothecin can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Camptothecin can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Camptothecin can be increased when it is combined with Nilotinib.
NisoldipineThe serum concentration of Camptothecin can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Camptothecin can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Camptothecin can be increased when it is combined with Nitrendipine.
NorethisteroneThe serum concentration of Camptothecin can be decreased when it is combined with Norethisterone.
OmeprazoleThe serum concentration of Camptothecin can be increased when it is combined with Omeprazole.
OuabainOuabain may decrease the cardiotoxic activities of Camptothecin.
P-NitrophenolThe serum concentration of Camptothecin can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Camptothecin can be increased when it is combined with Paclitaxel.
Palmitic AcidThe serum concentration of Camptothecin can be increased when it is combined with Palmitic Acid.
PantoprazoleThe serum concentration of Camptothecin can be increased when it is combined with Pantoprazole.
ParoxetineThe serum concentration of Camptothecin can be increased when it is combined with Paroxetine.
PerindoprilThe serum concentration of Camptothecin can be increased when it is combined with Perindopril.
PhenobarbitalThe serum concentration of Camptothecin can be decreased when it is combined with Phenobarbital.
PimozideThe serum concentration of Camptothecin can be increased when it is combined with Pimozide.
Platelet Activating FactorThe serum concentration of Camptothecin can be decreased when it is combined with Platelet Activating Factor.
PonatinibThe serum concentration of Camptothecin can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Camptothecin can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Camptothecin can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Camptothecin can be increased when it is combined with Prazosin.
PrednisoneThe serum concentration of Camptothecin can be increased when it is combined with Prednisone.
ProbenecidThe serum concentration of Camptothecin can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Camptothecin can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Camptothecin can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Camptothecin can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Camptothecin can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Camptothecin can be increased when it is combined with Protriptyline.
QuercetinThe serum concentration of Camptothecin can be increased when it is combined with Quercetin.
QuinacrineThe serum concentration of Camptothecin can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Camptothecin can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Camptothecin can be increased when it is combined with Quinine.
RanitidineThe serum concentration of Camptothecin can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Camptothecin can be increased when it is combined with Ranolazine.
ReboxetineThe serum concentration of Camptothecin can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Camptothecin can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Camptothecin can be decreased when it is combined with Reserpine.
RifampicinThe serum concentration of Camptothecin can be decreased when it is combined with Rifampicin.
RilpivirineThe serum concentration of Camptothecin can be increased when it is combined with Rilpivirine.
RitonavirThe serum concentration of Camptothecin can be decreased when it is combined with Ritonavir.
RolapitantThe serum concentration of Camptothecin can be increased when it is combined with Rolapitant.
SaquinavirThe serum concentration of Camptothecin can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Camptothecin can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Camptothecin can be increased when it is combined with Selegiline.
SertralineThe serum concentration of Camptothecin can be increased when it is combined with Sertraline.
SimeprevirThe serum concentration of Camptothecin can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Camptothecin can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Camptothecin can be decreased when it is combined with Sirolimus.
SorafenibThe serum concentration of Camptothecin can be increased when it is combined with Sorafenib.
SpironolactoneThe serum concentration of Camptothecin can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Camptothecin can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Camptothecin can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Camptothecin can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Camptothecin can be increased when it is combined with Sulfinpyrazone.
SumatriptanThe serum concentration of Camptothecin can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Camptothecin can be increased when it is combined with Sunitinib.
TacrineThe serum concentration of Camptothecin can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Camptothecin can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Camptothecin can be decreased when it is combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Camptothecin can be increased when it is combined with Taurocholic Acid.
TelmisartanThe serum concentration of Camptothecin can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Camptothecin can be increased when it is combined with Temsirolimus.
TerazosinThe serum concentration of Camptothecin can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Camptothecin can be increased when it is combined with Terfenadine.
TeriflunomideThe serum concentration of Camptothecin can be increased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Camptothecin can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Camptothecin can be increased when it is combined with Testosterone.
TicagrelorThe serum concentration of Camptothecin can be increased when it is combined with Ticagrelor.
TolvaptanThe serum concentration of Camptothecin can be increased when it is combined with Tolvaptan.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Camptothecin.
TrazodoneThe serum concentration of Camptothecin can be decreased when it is combined with Trazodone.
TrifluoperazineThe serum concentration of Camptothecin can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Camptothecin can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Camptothecin can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Camptothecin can be increased when it is combined with Trimipramine.
TroleandomycinThe serum concentration of Camptothecin can be increased when it is combined with Troleandomycin.
VenlafaxineThe serum concentration of Camptothecin can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Camptothecin can be decreased when it is combined with Verapamil.
VinblastineThe serum concentration of Camptothecin can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Camptothecin can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Camptothecin can be increased when it is combined with Vinorelbine.
ZimelidineThe serum concentration of Camptothecin can be increased when it is combined with Zimelidine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Poly(a) rna binding
Specific Function:
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphot...
Gene Name:
TOP1
Uniprot ID:
P11387
Molecular Weight:
90725.19 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Teicher BA: Next generation topoisomerase I inhibitors: Rationale and biomarker strategies. Biochem Pharmacol. 2008 Mar 15;75(6):1262-71. Epub 2007 Oct 22. [PubMed:18061144 ]
  3. van der Merwe M, Bjornsti MA: Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin. J Biol Chem. 2008 Feb 8;283(6):3305-15. Epub 2007 Dec 4. [PubMed:18056711 ]
  4. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Li D, Jang SH, Kim J, Wientjes MG, Au JL: Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res. 2003 Jan;20(1):45-50. [PubMed:12608535 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Ma Y, Wink M: The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. 2010 Jan;24(1):146-9. doi: 10.1002/ptr.2860. [PubMed:19548284 ]
Comments
comments powered by Disqus
Drug created on September 11, 2007 11:49 / Updated on August 17, 2016 12:24