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Identification Name 751689 Accession Number DB05255 Type Small Molecule Groups Investigational Description 751689 is orally-active calcilytics. Structure Synonyms External Identifiers Not Available Approved Prescription Products Not Available Approved Generic Prescription Products Not Available Approved Over the Counter Products Not Available Unapproved/Other Products Not Available International Brands Not Available Brand mixtures Not Available Salts Not Available Categories Not Available UNII DIH95YP7J3 CAS number Not Available Weight Not Available Chemical Formula Not Available InChI Key Not Available InChI Not Available IUPAC Name Not Available SMILES Not Available Pharmacology Indication Post-menopausal women with osteoporosis Structured Indications Not Available Pharmacodynamics Not Available Mechanism of action 751689 is novel small molecules that work by antagonizing calcium-sensing receptors on the surface of the parathyroid gland, thereby triggering a transient release of the body's own stores of parathyroid hormone (PTH). This release of PTH may have the potential to rebuild the bone mass lost as a result of osteoporosis and improve overall bone microarchitecture in these patients.
Target Kind Pharmacological action Actions Organism UniProt ID Extracellular calcium-sensing receptor Protein unknown Not Available Human P41180 details Adhesion G-protein coupled receptor F1 Protein unknown Not Available Human Q5T601 details Related Articles Absorption Not Available Volume of distribution Not Available Protein binding Not Available Metabolism Not Available Route of elimination Not Available Half life Not Available Clearance Not Available Toxicity Not Available Affected organisms Pathways Not Available SNP Mediated Effects Not Available SNP Mediated Adverse Drug Reactions Not Available Interactions Drug Interactions Not Available Food Interactions Not Available References Synthesis Reference Not Available General References Not Available External Links Not Available ATC Codes Not Available AHFS Codes Not Available PDB Entries Not Available FDA label Not Available MSDS Not Available ADMET Predicted ADMET features Not Available Pharmacoeconomics Manufacturers Not Available Packagers Not Available Dosage forms Not Available Prices Not Available Patents Not Available Properties State Solid Experimental Properties Not Available Predicted Properties Not Available Spectra Mass Spec (NIST) Not Available Spectra Taxonomy Classification Not classified Targets
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Drug created on November 18, 2007 11:09 / Updated on August 17, 2016 12:24