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Identification
NameEtravirine
Accession NumberDB06414
TypeSmall Molecule
GroupsApproved
DescriptionEtravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor(NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of adult HIV-1 infection documented to be resistant to therapy with other NNRTIs and antiretroviral agents. On March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 years of age, weighing at least 16 kg. Etravarine must always be used in combination with other antiretroviral drugs. Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1), and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma. Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, diarrhea and peripheral neuropathy. Patients are advised to immediately contact their healthcare provider if a rash develops. In 2009, postmarketing case reports of Stevens-Johnson Syndrome, toxic epidermal necrolysis, erythema multiforme, and other hypersensitivity reactions lead to a revision of etravirine's "Warnings and Precautions," as well as notification of health care providers. In 2013, reports of Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) in the setting of immune reconstitution, as well as more in depth information about the development of rashes in patients taking etravirine, lead to a modification of etravirine's monograph.
Structure
Thumb
Synonyms
Intelence
External Identifiers
  • R165335
  • TMC125
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Intelencetablet100 mgoralJanssen Inc2008-03-27Not applicableCanada
Intelencetablet100 mg/1oralREMEDYREPACK INC.2013-03-182016-04-05Us
IntelenceTablet200 mgOral useJanssen Cilag International Nv2008-08-28Not applicableEu
Intelencetablet100 mg/1oralJanssen Products LP2008-01-18Not applicableUs
Intelencetablet200 mgoralJanssen Inc2011-12-12Not applicableCanada
Intelencetablet100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IntelenceTablet25 mgOral useJanssen Cilag International Nv2008-08-28Not applicableEu
Intelencetablet200 mg/1oralJanssen Products LP2010-12-22Not applicableUs
Intelencetablet25 mgoralJanssen Inc2013-06-14Not applicableCanada
Intelencetablet100 mg/1oralPhysicians Total Care, Inc.2008-02-21Not applicableUs
Intelencetablet25 mg/1oralJanssen Products LP2012-03-26Not applicableUs
IntelenceTablet100 mgOral useJanssen Cilag International Nv2008-08-28Not applicableEu
Intelencetablet200 mg/1oralPhysicians Total Care, Inc.2012-10-10Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII0C50HW4FO1
CAS number269055-15-4
WeightAverage: 435.277
Monoisotopic: 434.049071779
Chemical FormulaC20H15BrN6O
InChI KeyInChIKey=PYGWGZALEOIKDF-UHFFFAOYSA-N
InChI
InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)
IUPAC Name
4-({6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile
SMILES
CC1=CC(=CC(C)=C1OC1=C(Br)C(N)=NC(NC2=CC=C(C=C2)C#N)=N1)C#N
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
KingdomOrganic compounds
Super ClassOrganooxygen compounds
ClassEthers
Sub ClassDiarylethers
Direct ParentDiarylethers
Alternative Parents
Substituents
  • Diaryl ether
  • Benzonitrile
  • Halopyrimidine
  • Aminopyrimidine
  • Imidolactam
  • Benzenoid
  • Pyrimidine
  • Primary aromatic amine
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl bromide
  • Heteroaromatic compound
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Nitrile
  • Carbonitrile
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Organobromide
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationIndicated as an adjunct therapy in the treatment of adult HIV-1 infections resistant to therapy with other NNRTIs and antiretroviral agents.
PharmacodynamicsClinical trials have shown no prolongation of QT intervals on electrocardiograms after 8 days of dosing.
Mechanism of actionEtravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1). It directly binds reverse transcriptase and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma.
Related Articles
AbsorptionMaximum oral absorption is achieved in 2.5-4 hours. Absorption is unaffected by the concomitant use of oral ranitidine or omeprazole, which decrease gastric acidity. Administration under fasting conditions resulted in a near 50% decrease in systemic exposure (AUC) when compared to administration after a meal.
Volume of distribution

Distribution of etravirine into compartments other than plasma has not been evaluated in humans.

Protein bindingPlasma protein binding is about 99.9% in vitro. In vitro, 99.6% is bound to albumin, and 97.66% - 99.02% is bound to 1-alpha glycoprotein.
Metabolism

Metabolized (in vitro) by the liver CYP450 enzymes: CYP3A4, CYP2C9, CYP2C19. The major metabolites formed by a methyl hydroxylation of the dimethylbenzonitrile moiety retained less than 90% of etravirine's activity.

Route of eliminationAfter a 800mg dose of radio-labelled etraverine, 93.7% was found to undergo fecal elimination, with 81.2% - 86.4% eliminated unchanged. 1.2% of the dose was renally eliminated, changed. Etravirine is dialyzable (hemodialysis).
Half lifeHalf life of 9.05-41 hours.
Clearance

Renal clearance of etravirine is negligible (<1.2%), thus no dose adjustments are required in patients with renal impairment.

Clearance is shown to be reduced in patients with Hepatitis B and/or co-infection, however, the safety profile of etravirine does not call for dosage adjustments.

ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Tabletoral100 mg/1
Tabletoral100 mg
Tabletoral200 mg/1
Tabletoral200 mg
Tabletoral25 mg/1
Tabletoral25 mg
TabletOral use100 mg
TabletOral use200 mg
TabletOral use25 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2350801 No2008-05-202019-09-24Canada
CA2651665 No2010-04-272027-06-06Canada
US6878717 No1999-11-052019-11-05Us
US7037917 No2000-12-132020-12-13Us
US7887845 No1999-03-252019-03-25Us
US8003789 No1999-11-012019-11-01Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0169 mg/mLALOGPS
logP3.67ALOGPS
logP5.54ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.49ChemAxon
pKa (Strongest Basic)4.13ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area120.64 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity111.87 m3·mol-1ChemAxon
Polarizability41.09 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ05AG04
AHFS CodesNot Available
PDB Entries
FDA labelDownload (642 KB)
MSDSDownload (122 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Etravirine can be decreased when it is combined with 1,10-Phenanthroline.
2-HYDROXY-1,4-NAPHTHOQUINONEThe serum concentration of Etravirine can be increased when it is combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.
2-mercaptobenzothiazoleThe serum concentration of Etravirine can be increased when it is combined with 2-mercaptobenzothiazole.
3,4-DichloroisocoumarinThe serum concentration of Etravirine can be decreased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Etravirine can be decreased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Etravirine.
AbirateroneThe metabolism of Etravirine can be decreased when combined with Abiraterone.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Etravirine.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Etravirine.
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Etravirine.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Etravirine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Etravirine.
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Etravirine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Etravirine.
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Etravirine.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Etravirine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Etravirine.
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Etravirine.
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Etravirine.
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Etravirine.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Etravirine.
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Etravirine.
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Etravirine.
AlogliptinThe serum concentration of Etravirine can be decreased when it is combined with Alogliptin.
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Etravirine.
Alpha-1-proteinase inhibitorThe serum concentration of Etravirine can be decreased when it is combined with Alpha-1-proteinase inhibitor.
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Etravirine.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Etravirine.
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Etravirine.
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Etravirine.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Etravirine.
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Etravirine.
AmiodaroneThe metabolism of Etravirine can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Etravirine.
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Etravirine.
AmorolfineThe serum concentration of Etravirine can be increased when it is combined with Amorolfine.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Etravirine.
Amphotericin BThe serum concentration of Etravirine can be increased when it is combined with Amphotericin B.
AmprenavirThe serum concentration of Etravirine can be decreased when it is combined with Amprenavir.
AN2690The serum concentration of Etravirine can be increased when it is combined with AN2690.
AnidulafunginThe serum concentration of Etravirine can be increased when it is combined with Anidulafungin.
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Etravirine.
Antithrombin III humanThe serum concentration of Etravirine can be decreased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Etravirine can be decreased when it is combined with Apixaban.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Etravirine.
AprepitantThe serum concentration of Etravirine can be increased when it is combined with Aprepitant.
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Etravirine.
AprotininThe serum concentration of Etravirine can be decreased when it is combined with Aprotinin.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Etravirine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Etravirine.
ArgatrobanThe serum concentration of Etravirine can be decreased when it is combined with Argatroban.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Etravirine.
ArmodafinilThe metabolism of Etravirine can be decreased when combined with Armodafinil.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Etravirine.
ArtemetherThe serum concentration of Etravirine can be increased when it is combined with Artemether.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Etravirine resulting in a loss in efficacy.
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Etravirine.
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Etravirine.
AsunaprevirThe serum concentration of Etravirine can be decreased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Etravirine can be decreased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Etravirine.
AtomoxetineThe metabolism of Etravirine can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Etravirine.
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Etravirine.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Etravirine.
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Etravirine.
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Etravirine.
Bafilomycin A1The serum concentration of Etravirine can be increased when it is combined with Bafilomycin A1.
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Etravirine.
BatimastatThe serum concentration of Etravirine can be decreased when it is combined with Batimastat.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Etravirine.
BenazeprilThe serum concentration of Etravirine can be decreased when it is combined with Benazepril.
BenzamidineThe serum concentration of Etravirine can be decreased when it is combined with Benzamidine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Etravirine.
Benzoic AcidThe serum concentration of Etravirine can be increased when it is combined with Benzoic Acid.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Etravirine.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Etravirine.
BepridilThe serum concentration of Bepridil can be decreased when it is combined with Etravirine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Etravirine.
BexaroteneThe serum concentration of Etravirine can be decreased when it is combined with Bexarotene.
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Etravirine.
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Etravirine.
BifonazoleThe serum concentration of Etravirine can be increased when it is combined with Bifonazole.
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Etravirine.
BivalirudinThe serum concentration of Etravirine can be decreased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Etravirine can be decreased when it is combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Etravirine.
BortezomibThe metabolism of Etravirine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Etravirine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Etravirine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Etravirine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Etravirine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Etravirine.
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Etravirine.
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Etravirine.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Etravirine.
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Etravirine.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Etravirine.
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Etravirine.
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Etravirine.
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Etravirine.
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Etravirine.
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Etravirine.
ButenafineThe serum concentration of Etravirine can be increased when it is combined with Butenafine.
ButoconazoleThe serum concentration of Etravirine can be increased when it is combined with Butoconazole.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Etravirine.
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Etravirine.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Etravirine.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Etravirine.
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Etravirine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Etravirine.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Etravirine.
CandesartanThe metabolism of Candesartan can be decreased when combined with Etravirine.
CandicidinThe serum concentration of Etravirine can be increased when it is combined with Candicidin.
CandoxatrilThe serum concentration of Etravirine can be decreased when it is combined with Candoxatril.
CapecitabineThe metabolism of Etravirine can be decreased when combined with Capecitabine.
CaptoprilThe serum concentration of Etravirine can be decreased when it is combined with Captopril.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Etravirine.
CarbamazepineThe metabolism of Etravirine can be increased when combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Etravirine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Etravirine.
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Etravirine.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Etravirine.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Etravirine.
CaspofunginThe serum concentration of Etravirine can be increased when it is combined with Caspofungin.
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Etravirine.
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Etravirine.
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Etravirine.
CeritinibThe serum concentration of Etravirine can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Etravirine.
CeruleninThe serum concentration of Etravirine can be increased when it is combined with Cerulenin.
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Etravirine.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Etravirine.
ChloramphenicolThe metabolism of Etravirine can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Etravirine.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Etravirine.
ChloroxineThe serum concentration of Etravirine can be increased when it is combined with Chloroxine.
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Etravirine.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Etravirine.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Etravirine.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Etravirine.
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Etravirine.
CholecalciferolThe metabolism of Etravirine can be decreased when combined with Cholecalciferol.
ChymostatinThe serum concentration of Etravirine can be decreased when it is combined with Chymostatin.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Etravirine.
CiclopiroxThe serum concentration of Etravirine can be increased when it is combined with Ciclopirox.
CilastatinThe serum concentration of Etravirine can be decreased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Etravirine can be decreased when it is combined with Cilazapril.
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Etravirine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Etravirine.
CimetidineThe metabolism of Etravirine can be decreased when combined with Cimetidine.
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Etravirine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Etravirine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Etravirine.
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Etravirine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Etravirine.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Etravirine.
CitalopramThe metabolism of Etravirine can be decreased when combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Etravirine.
ClarithromycinThe metabolism of Etravirine can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Etravirine can be decreased when combined with Clemastine.
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Etravirine.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Etravirine.
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Etravirine.
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Etravirine.
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Etravirine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Etravirine.
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Etravirine.
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Etravirine.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Etravirine.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Etravirine.
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Etravirine.
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Etravirine.
ClotrimazoleThe metabolism of Etravirine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Etravirine.
CobicistatThe metabolism of Etravirine can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Etravirine.
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Etravirine.
CodeineThe serum concentration of Codeine can be decreased when it is combined with Etravirine.
Coenzyme Q10The serum concentration of Coenzyme Q10 can be decreased when it is combined with Etravirine.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Etravirine.
ConivaptanThe serum concentration of Etravirine can be increased when it is combined with Conivaptan.
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Etravirine.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Etravirine.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Etravirine.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Etravirine.
CrizotinibThe metabolism of Etravirine can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Etravirine.
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Etravirine.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Etravirine.
CyclosporineThe metabolism of Etravirine can be decreased when combined with Cyclosporine.
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Etravirine.
Dabigatran etexilateThe serum concentration of Etravirine can be decreased when it is combined with Dabigatran etexilate.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Etravirine.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Etravirine.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Etravirine.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Etravirine.
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Etravirine.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Etravirine.
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Etravirine.
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Etravirine.
DarunavirThe serum concentration of Etravirine can be decreased when it is combined with Darunavir.
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Etravirine.
DasatinibThe serum concentration of Etravirine can be increased when it is combined with Dasatinib.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Etravirine.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Etravirine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Etravirine.
Decanoic AcidThe serum concentration of Etravirine can be increased when it is combined with Decanoic Acid.
DeferasiroxThe serum concentration of Etravirine can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Etravirine.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Etravirine.
DelavirdineThe metabolism of Etravirine can be decreased when combined with Delavirdine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Etravirine.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Etravirine.
DexamethasoneThe serum concentration of Etravirine can be decreased when it is combined with Dexamethasone.
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Etravirine.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Etravirine.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Etravirine.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Etravirine.
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Etravirine.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Etravirine.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Etravirine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Etravirine.
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Etravirine.
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Etravirine.
DihydroergotamineThe metabolism of Etravirine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Etravirine.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Etravirine.
DiltiazemThe metabolism of Etravirine can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Etravirine.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Etravirine.
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Etravirine.
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Etravirine.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Etravirine.
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Etravirine.
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Etravirine.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Etravirine.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Etravirine.
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Etravirine.
DopamineThe metabolism of Dopamine can be decreased when combined with Etravirine.
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Etravirine.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Etravirine.
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Etravirine.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Etravirine.
DoxycyclineThe metabolism of Etravirine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Etravirine.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Etravirine.
DronedaroneThe metabolism of Etravirine can be decreased when combined with Dronedarone.
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Etravirine.
EcabetThe serum concentration of Etravirine can be decreased when it is combined with Ecabet.
EconazoleThe serum concentration of Etravirine can be increased when it is combined with Econazole.
EdoxabanThe serum concentration of Etravirine can be decreased when it is combined with Edoxaban.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Etravirine.
EfavirenzThe serum concentration of Etravirine can be decreased when it is combined with Efavirenz.
EfinaconazoleThe serum concentration of Etravirine can be increased when it is combined with Efinaconazole.
ElafinThe serum concentration of Etravirine can be decreased when it is combined with Elafin.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Etravirine.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Etravirine.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Etravirine.
EnalaprilThe serum concentration of Etravirine can be decreased when it is combined with Enalapril.
EnalaprilatThe serum concentration of Etravirine can be decreased when it is combined with Enalaprilat.
EnalkirenThe serum concentration of Etravirine can be decreased when it is combined with Enalkiren.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Etravirine.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Etravirine.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Etravirine.
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Etravirine.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Etravirine.
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Etravirine.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Etravirine.
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Etravirine.
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Etravirine.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Etravirine.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Etravirine.
ErythromycinThe metabolism of Etravirine can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Etravirine.
Eslicarbazepine acetateThe serum concentration of Etravirine can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Etravirine.
EsomeprazoleThe metabolism of Etravirine can be decreased when combined with Esomeprazole.
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Etravirine.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Etravirine.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Etravirine.
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Etravirine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Etravirine.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Etravirine.
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Etravirine.
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Etravirine.
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Etravirine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Etravirine.
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Etravirine.
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Etravirine.
EtodolacThe metabolism of Etodolac can be decreased when combined with Etravirine.
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Etravirine.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Etravirine.
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Etravirine.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Etravirine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Etravirine.
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Etravirine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Etravirine.
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Etravirine.
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Etravirine.
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Etravirine.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Etravirine.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Etravirine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Etravirine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Etravirine.
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Etravirine.
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Etravirine.
FlecainideThe serum concentration of Flecainide can be decreased when it is combined with Etravirine.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Etravirine.
FloxuridineThe metabolism of Etravirine can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Etravirine can be decreased when combined with Fluconazole.
FlucytosineThe serum concentration of Etravirine can be increased when it is combined with Flucytosine.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Etravirine.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Etravirine.
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Etravirine.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Etravirine.
FluorouracilThe metabolism of Etravirine can be decreased when combined with Fluorouracil.
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Etravirine.
FluoxetineThe metabolism of Etravirine can be decreased when combined with Fluoxetine.
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Etravirine.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Etravirine.
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Etravirine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Etravirine.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Etravirine.
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Etravirine.
FluvastatinThe metabolism of Etravirine can be decreased when combined with Fluvastatin.
FluvoxamineThe metabolism of Etravirine can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Etravirine.
FosamprenavirThe serum concentration of Etravirine can be decreased when it is combined with Fosamprenavir.
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Etravirine.
FosaprepitantThe serum concentration of Etravirine can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Etravirine can be decreased when it is combined with Fosinopril.
FosphenytoinThe serum concentration of Etravirine can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Etravirine.
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Etravirine.
Fusidic AcidThe serum concentration of Etravirine can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Etravirine.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Etravirine.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Etravirine.
GeldanamycinThe serum concentration of Etravirine can be decreased when it is combined with Geldanamycin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Etravirine.
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Etravirine.
GemfibrozilThe metabolism of Etravirine can be decreased when combined with Gemfibrozil.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Etravirine.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Etravirine.
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Etravirine.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Etravirine.
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Etravirine.
GlyphosateThe serum concentration of Etravirine can be increased when it is combined with Glyphosate.
GM6001The serum concentration of Etravirine can be decreased when it is combined with GM6001.
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Etravirine.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Etravirine.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Etravirine.
GriseofulvinThe serum concentration of Etravirine can be increased when it is combined with Griseofulvin.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Etravirine.
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Etravirine.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Etravirine.
HaloproginThe serum concentration of Etravirine can be increased when it is combined with Haloprogin.
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Etravirine.
HexetidineThe serum concentration of Etravirine can be increased when it is combined with Hexetidine.
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Etravirine.
HirulogThe serum concentration of Etravirine can be decreased when it is combined with Hirulog.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Etravirine.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Etravirine.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Etravirine.
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Etravirine.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Etravirine.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Etravirine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Etravirine.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Etravirine.
IdelalisibThe serum concentration of Etravirine can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Etravirine resulting in a loss in efficacy.
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Etravirine.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Etravirine.
ImatinibThe metabolism of Etravirine can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Etravirine.
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Etravirine.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Etravirine.
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Etravirine.
IndinavirThe serum concentration of Etravirine can be decreased when it is combined with Indinavir.
indisulamThe metabolism of indisulam can be decreased when combined with Etravirine.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Etravirine.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Etravirine.
IrbesartanThe metabolism of Etravirine can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Etravirine.
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Etravirine.
IsavuconazoniumThe metabolism of Etravirine can be decreased when combined with Isavuconazonium.
IsoconazoleThe serum concentration of Etravirine can be increased when it is combined with Isoconazole.
IsoflurophateThe serum concentration of Etravirine can be decreased when it is combined with Isoflurophate.
IsoniazidThe metabolism of Etravirine can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Etravirine.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Etravirine.
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Etravirine.
IsradipineThe metabolism of Etravirine can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Etravirine can be increased when it is combined with Itraconazole.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Etravirine.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Etravirine.
IvacaftorThe serum concentration of Etravirine can be increased when it is combined with Ivacaftor.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Etravirine.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Etravirine.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Etravirine.
IxazomibThe serum concentration of Etravirine can be decreased when it is combined with Ixazomib.
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Etravirine.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Etravirine.
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Etravirine.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Etravirine.
KetoconazoleThe metabolism of Etravirine can be decreased when combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Etravirine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Etravirine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Etravirine.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Etravirine.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Etravirine.
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Etravirine.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Etravirine.
LeflunomideThe metabolism of Etravirine can be decreased when combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Etravirine.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Etravirine.
LepirudinThe serum concentration of Etravirine can be decreased when it is combined with Lepirudin.
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Etravirine.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Etravirine.
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Etravirine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Etravirine.
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Etravirine.
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Etravirine.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Etravirine.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Etravirine.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Etravirine.
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Etravirine.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Etravirine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Etravirine.
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Etravirine.
LinagliptinThe serum concentration of Etravirine can be decreased when it is combined with Linagliptin.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Etravirine.
LisinoprilThe serum concentration of Etravirine can be decreased when it is combined with Lisinopril.
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Etravirine.
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Etravirine.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Etravirine.
LopinavirThe serum concentration of Etravirine can be decreased when it is combined with Lopinavir.
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Etravirine.
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Etravirine.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Etravirine.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Etravirine.
LosartanThe metabolism of Etravirine can be decreased when combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Etravirine.
LovastatinThe metabolism of Etravirine can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Etravirine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Etravirine can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Etravirine.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Etravirine.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Etravirine.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Etravirine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Etravirine.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Etravirine.
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Etravirine.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Etravirine.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Etravirine.
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Etravirine.
MelatoninThe metabolism of Melatonin can be decreased when combined with Etravirine.
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Etravirine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Etravirine.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Etravirine.
MestranolThe metabolism of Mestranol can be decreased when combined with Etravirine.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Etravirine.
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Etravirine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Etravirine.
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Etravirine.
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Etravirine.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Etravirine.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Etravirine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Etravirine.
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Etravirine.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Etravirine.
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Etravirine.
MevastatinThe serum concentration of Etravirine can be increased when it is combined with Mevastatin.
MevastatinThe serum concentration of Mevastatin can be decreased when it is combined with Etravirine.
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Etravirine.
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Etravirine.
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Etravirine.
MicafunginThe serum concentration of Etravirine can be increased when it is combined with Micafungin.
MiconazoleThe serum concentration of Etravirine can be increased when it is combined with Miconazole.
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Etravirine.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Etravirine.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Etravirine.
MifepristoneThe metabolism of Etravirine can be decreased when combined with Mifepristone.
MiltefosineThe serum concentration of Etravirine can be increased when it is combined with Miltefosine.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Etravirine.
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Etravirine.
MitotaneThe serum concentration of Etravirine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Etravirine.
MoclobemideThe metabolism of Etravirine can be decreased when combined with Moclobemide.
ModafinilThe serum concentration of Etravirine can be decreased when it is combined with Modafinil.
MoexiprilThe serum concentration of Etravirine can be decreased when it is combined with Moexipril.
MonensinThe serum concentration of Etravirine can be increased when it is combined with Monensin.
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Etravirine.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Etravirine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Etravirine.
MyxothiazolThe serum concentration of Etravirine can be increased when it is combined with Myxothiazol.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Etravirine can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NadololThe serum concentration of Nadolol can be increased when it is combined with Etravirine.
NafcillinThe serum concentration of Etravirine can be decreased when it is combined with Nafcillin.
NaftifineThe serum concentration of Etravirine can be increased when it is combined with Naftifine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Etravirine.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Etravirine.
NaproxenThe metabolism of Naproxen can be decreased when combined with Etravirine.
NatamycinThe serum concentration of Etravirine can be increased when it is combined with Natamycin.
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Etravirine.
NCX 4016The serum concentration of Etravirine can be decreased when it is combined with NCX 4016.
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Etravirine.
NefazodoneThe metabolism of Etravirine can be decreased when combined with Nefazodone.
NelfinavirThe serum concentration of Etravirine can be decreased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Etravirine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Etravirine.
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Etravirine.
NevirapineThe metabolism of Etravirine can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Etravirine.
NicardipineThe metabolism of Etravirine can be decreased when combined with Nicardipine.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Etravirine.
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Etravirine.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Etravirine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Etravirine.
NilotinibThe metabolism of Etravirine can be decreased when combined with Nilotinib.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Etravirine.
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Etravirine.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Etravirine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Etravirine.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Etravirine.
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Etravirine.
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Etravirine.
NitroxolineThe serum concentration of Etravirine can be increased when it is combined with Nitroxoline.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Etravirine.
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Etravirine.
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Etravirine.
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Etravirine.
NystatinThe serum concentration of Etravirine can be increased when it is combined with Nystatin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Etravirine.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Etravirine.
OlaparibThe metabolism of Etravirine can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Etravirine.
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Etravirine.
OmapatrilatThe serum concentration of Etravirine can be decreased when it is combined with Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Etravirine.
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Etravirine.
OmeprazoleThe metabolism of Etravirine can be decreased when combined with Omeprazole.
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Etravirine.
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Etravirine.
OsimertinibThe serum concentration of Etravirine can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Etravirine.
OtamixabanThe serum concentration of Etravirine can be decreased when it is combined with Otamixaban.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Etravirine.
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Etravirine.
OxiconazoleThe serum concentration of Etravirine can be increased when it is combined with Oxiconazole.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Etravirine.
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Etravirine.
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Etravirine.
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Etravirine.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Etravirine.
pafuramidineThe serum concentration of Etravirine can be increased when it is combined with pafuramidine.
PalbociclibThe serum concentration of Etravirine can be increased when it is combined with Palbociclib.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Etravirine.
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Etravirine.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Etravirine.
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Etravirine.
PantoprazoleThe metabolism of Etravirine can be decreased when combined with Pantoprazole.
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Etravirine.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Etravirine.
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Etravirine.
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Etravirine.
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Etravirine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Etravirine.
PentamidineThe serum concentration of Etravirine can be increased when it is combined with Pentamidine.
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Etravirine.
PentobarbitalThe metabolism of Etravirine can be increased when combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Etravirine.
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Etravirine.
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Etravirine.
PerindoprilThe serum concentration of Etravirine can be decreased when it is combined with Perindopril.
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Etravirine.
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Etravirine.
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Etravirine.
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Etravirine.
PhenobarbitalThe serum concentration of Etravirine can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Etravirine.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Etravirine.
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Etravirine.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Etravirine.
PhenytoinThe serum concentration of Etravirine can be decreased when it is combined with Phenytoin.
PhosphoramidonThe serum concentration of Etravirine can be decreased when it is combined with Phosphoramidon.
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Etravirine.
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Etravirine.
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Etravirine.
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Etravirine.
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Etravirine.
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Etravirine.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Etravirine.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Etravirine.
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Etravirine.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Etravirine.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Etravirine.
PosaconazoleThe serum concentration of Etravirine can be increased when it is combined with Posaconazole.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Etravirine.
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Etravirine.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Etravirine.
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Etravirine.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Etravirine.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Etravirine.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Etravirine.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Etravirine.
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Etravirine.
PrimidoneThe serum concentration of Etravirine can be decreased when it is combined with Primidone.
PrimidoneThe metabolism of Primidone can be decreased when combined with Etravirine.
PrinomastatThe serum concentration of Etravirine can be decreased when it is combined with Prinomastat.
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Etravirine.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Etravirine.
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Etravirine.
PromazineThe serum concentration of Promazine can be decreased when it is combined with Etravirine.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Etravirine.
PropofolThe serum concentration of Propofol can be decreased when it is combined with Etravirine.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Etravirine.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Etravirine.
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Etravirine.
PyrimethamineThe metabolism of Etravirine can be decreased when combined with Pyrimethamine.
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Etravirine.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Etravirine.
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Etravirine.
QuinaprilThe serum concentration of Etravirine can be decreased when it is combined with Quinapril.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Etravirine.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Etravirine.
QuinineThe metabolism of Etravirine can be decreased when combined with Quinine.
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Etravirine.
RadicicolThe serum concentration of Etravirine can be increased when it is combined with Radicicol.
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Etravirine.
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Etravirine.
RamiprilThe serum concentration of Etravirine can be decreased when it is combined with Ramipril.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Etravirine.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Etravirine.
RanolazineThe metabolism of Etravirine can be decreased when combined with Ranolazine.
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Etravirine.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Etravirine.
RemikirenThe serum concentration of Etravirine can be decreased when it is combined with Remikiren.
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Etravirine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Etravirine.
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Etravirine.
RifabutinThe serum concentration of Etravirine can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Etravirine.
RifampicinThe metabolism of Etravirine can be increased when combined with Rifampicin.
RifapentineThe metabolism of Etravirine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Etravirine.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Etravirine.
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Etravirine.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Etravirine.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Etravirine.
RitonavirThe serum concentration of Etravirine can be decreased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Etravirine can be decreased when it is combined with Rivaroxaban.
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Etravirine.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Etravirine.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Etravirine.
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Etravirine.
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Etravirine.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Etravirine.
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Etravirine.
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Etravirine.
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Etravirine.
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Etravirine.
Salicylhydroxamic AcidThe serum concentration of Etravirine can be increased when it is combined with Salicylhydroxamic Acid.
Salicylic acidThe serum concentration of Etravirine can be increased when it is combined with Salicylic acid.
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Etravirine.
SaquinavirThe serum concentration of Etravirine can be decreased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Etravirine.
SecobarbitalThe metabolism of Etravirine can be increased when combined with Secobarbital.
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Etravirine.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Etravirine.
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Etravirine.
SertaconazoleThe serum concentration of Etravirine can be increased when it is combined with Sertaconazole.
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Etravirine.
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Etravirine.
SertralineThe metabolism of Etravirine can be decreased when combined with Sertraline.
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Etravirine.
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Etravirine.
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Etravirine.
SildenafilThe metabolism of Etravirine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Etravirine.
SiltuximabThe serum concentration of Etravirine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Etravirine can be increased when it is combined with Simeprevir.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Etravirine.
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Etravirine.
SinefunginThe serum concentration of Etravirine can be increased when it is combined with Sinefungin.
SirolimusThe serum concentration of Etravirine can be increased when it is combined with Sirolimus.
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Etravirine.
SitagliptinThe serum concentration of Etravirine can be decreased when it is combined with Sitagliptin.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Etravirine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Etravirine.
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Etravirine.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Etravirine.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Etravirine.
SorafenibThe metabolism of Etravirine can be decreased when combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Etravirine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Etravirine.
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Etravirine.
SpiraprilThe serum concentration of Etravirine can be decreased when it is combined with Spirapril.
St. John's WortThe serum concentration of Etravirine can be decreased when it is combined with St. John&#39;s Wort.
StiripentolThe serum concentration of Etravirine can be increased when it is combined with Stiripentol.
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Etravirine.
SulconazoleThe serum concentration of Etravirine can be increased when it is combined with Sulconazole.
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Etravirine.
SulfadiazineThe metabolism of Etravirine can be decreased when combined with Sulfadiazine.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Etravirine.
SulfamethoxazoleThe metabolism of Etravirine can be decreased when combined with Sulfamethoxazole.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Etravirine.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Etravirine.
SulfisoxazoleThe metabolism of Etravirine can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Etravirine.
SuprofenThe metabolism of Suprofen can be decreased when combined with Etravirine.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Etravirine.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Etravirine.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Etravirine.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Etravirine.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Etravirine.
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Etravirine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Etravirine.
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Etravirine.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Etravirine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Etravirine.
TavaboroleThe serum concentration of Etravirine can be increased when it is combined with Tavaborole.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Etravirine.
TelaprevirThe serum concentration of Etravirine can be decreased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Etravirine.
TelithromycinThe metabolism of Etravirine can be decreased when combined with Telithromycin.
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Etravirine.
TemocaprilThe serum concentration of Etravirine can be decreased when it is combined with Temocapril.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Etravirine.
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Etravirine.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Etravirine.
TerbinafineThe serum concentration of Etravirine can be increased when it is combined with Terbinafine.
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Etravirine.
TerconazoleThe serum concentration of Etravirine can be increased when it is combined with Terconazole.
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Etravirine.
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Etravirine.
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Etravirine.
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Etravirine.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Etravirine.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Etravirine.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Etravirine.
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Etravirine.
ThiorphanThe serum concentration of Etravirine can be decreased when it is combined with Thiorphan.
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Etravirine.
ThymolThe serum concentration of Etravirine can be increased when it is combined with Thymol.
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Etravirine.
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Etravirine.
TicagrelorThe metabolism of Etravirine can be decreased when combined with Ticagrelor.
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Etravirine.
TiclopidineThe metabolism of Etravirine can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Etravirine.
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Etravirine.
TioconazoleThe serum concentration of Etravirine can be increased when it is combined with Tioconazole.
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Etravirine.
TipranavirThe serum concentration of Etravirine can be decreased when it is combined with Tipranavir.
TocilizumabThe serum concentration of Etravirine can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Etravirine.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Etravirine.
TolnaftateThe serum concentration of Etravirine can be increased when it is combined with Tolnaftate.
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Etravirine.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Etravirine.
TopiramateThe metabolism of Etravirine can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Etravirine.
TorasemideThe metabolism of Torasemide can be decreased when combined with Etravirine.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Etravirine.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Etravirine.
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Etravirine.
TrandolaprilThe serum concentration of Etravirine can be decreased when it is combined with Trandolapril.
TranylcypromineThe metabolism of Etravirine can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Etravirine.
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Etravirine.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Etravirine.
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Etravirine.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Etravirine.
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Etravirine.
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Etravirine.
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Etravirine.
TrimethoprimThe metabolism of Etravirine can be decreased when combined with Trimethoprim.
TrimetrexateThe serum concentration of Etravirine can be increased when it is combined with Trimetrexate.
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Etravirine.
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Etravirine.
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Etravirine.
UbenimexThe serum concentration of Etravirine can be decreased when it is combined with Ubenimex.
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Etravirine.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Etravirine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Etravirine.
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Etravirine.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Etravirine.
ValsartanThe metabolism of Etravirine can be decreased when combined with Valsartan.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Etravirine.
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Etravirine.
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Etravirine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Etravirine.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Etravirine.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Etravirine.
VenlafaxineThe metabolism of Etravirine can be decreased when combined with Venlafaxine.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Etravirine.
VerapamilThe metabolism of Etravirine can be decreased when combined with Verapamil.
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Etravirine.
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Etravirine.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Etravirine.
VildagliptinThe serum concentration of Etravirine can be decreased when it is combined with Vildagliptin.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Etravirine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Etravirine.
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Etravirine.
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Etravirine.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Etravirine.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Etravirine.
VoriconazoleThe metabolism of Etravirine can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Etravirine.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Etravirine.
XimelagatranThe serum concentration of Etravirine can be decreased when it is combined with Ximelagatran.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Etravirine.
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Etravirine.
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Etravirine.
ZafirlukastThe metabolism of Etravirine can be decreased when combined with Zafirlukast.
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Etravirine.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Etravirine.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Etravirine.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Etravirine.
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Etravirine.
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Etravirine.
ZiprasidoneThe metabolism of Etravirine can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Etravirine.
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Etravirine.
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Etravirine.
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Etravirine.
Food InteractionsNot Available

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Perez VE, Sanchez-Parra C, Serrano Villar S: [Etravirine drug interactions]. Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1. [PubMed:20116625 ]
  2. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  3. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Perez VE, Sanchez-Parra C, Serrano Villar S: [Etravirine drug interactions]. Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1. [PubMed:20116625 ]
  2. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  3. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Perez VE, Sanchez-Parra C, Serrano Villar S: [Etravirine drug interactions]. Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1. [PubMed:20116625 ]
  2. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  3. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  2. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi ...
Gene Name:
ABCB4
Uniprot ID:
P21439
Molecular Weight:
141521.845 Da
References
  1. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  2. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
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Drug created on March 19, 2008 10:32 / Updated on September 30, 2016 02:26