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targets (13)
for drugs
Identification
Name UBIQUINONE-1
Accession Number DB08689
Type small molecule
Groups experimental
Description Not Available
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories Not Available
CAS number Not Available
Weight Average: 250.2903
Monoisotopic: 250.120509064
Chemical Formula C14H18O4
InChI Key InChIKey=SOECUQMRSRVZQQ-UHFFFAOYSA-N
InChI
InChI=1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3
Plain Text
IUPAC Name
2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en-1-yl)cyclohexa-2,5-diene-1,4-dione
SMILES
COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 2.39e-01 g/l ALOGPS
logP 2.2 ALOGPS
logP 2.22 ChemAxon
logS -3 ALOGPS
pKa (strongest basic) -4.7 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 4 ChemAxon
hydrogen donor count 0 ChemAxon
polar surface area 52.6 ChemAxon
rotatable bond count 4 ChemAxon
refractivity 72.38 ChemAxon
polarizability 26.85 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
ChemSpider 4307 Link_out
ChEBI 46234 Link_out
ChEMBL 46234 Link_out
HET UQ1 Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries Not Available
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Photosynthetic reaction center cytochrome c subunit

Pharmacological action: unknown

The reaction center of purple bacteria contain a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor

Organism class: bacterial
UniProt ID: P07173 Link_out
Gene: pufC Link_out
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

2. Reaction center protein H chain

Pharmacological action: unknown

The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis

Organism class: bacterial
UniProt ID: P06008 Link_out
Gene: puhA Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

3. Reaction center protein L chain

Pharmacological action: unknown

The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis

Organism class: bacterial
UniProt ID: P06009 Link_out
Gene: pufL Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

4. Reaction center protein M chain

Pharmacological action: unknown

The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis

Organism class: bacterial
UniProt ID: P06010 Link_out
Gene: pufM Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

5. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: P31040 Link_out
Gene: SDHA Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

6. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Pharmacological action: unknown

Succinate + ubiquinone = fumarate + ubiquinol

Organism class: human
UniProt ID: P21912 Link_out
Gene: SDHB Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

7. Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: O14521 Link_out
Gene: SDHD Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

8. Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Pharmacological action: unknown

Mono-heme cytochrome b. May act as a mediator of low potential couples in an electron flow through cardiac complex II. Is involved in system II of the mitochondrial electron transport chain which is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Organism class: human
UniProt ID: Q99643 Link_out
Gene: SDHC Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

9. Thiol:disulfide interchange protein dsbA

Pharmacological action: unknown

Required for disulfide bond formation in some periplasmic proteins such as phoA or ompA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by dsbB. It is required for pilus biogenesis

Organism class: bacterial
UniProt ID: P0AEG4 Link_out
Gene: dsbA Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

10. Disulfide bond formation protein B

Pharmacological action: unknown

Required for disulfide bond formation in some periplasmic proteins such as phoA or ompA. Acts by oxidizing the dsbA protein

Organism class: bacterial
UniProt ID: P0A6M2 Link_out
Gene: dsbB Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

11. NrfC protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q72LA5 Link_out
Gene: nrfC Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

12. Thiosulfate reductase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q72LA4 Link_out
Gene: TT_C0155
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

13. Hypothetical membrane spanning protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q72LA6 Link_out
Gene: TT_C0153
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed
Comments
Drug created on September 15, 2010 15:33 / Updated on February 08, 2013 16:27