This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Hydrogen fluoride is a compound used in dentistry to prevent dental caries.
- Brand Names
- Oral-B Minute-foam, Perfect Choice One Minute
- Generic Name
- Hydrogen fluoride
- DrugBank Accession Number
- DB11072
- Background
Hydrogen fluoride (Hydrofluoric acid) is a weak acid that is a precursor to almost all fluorine compounds, including pharmaceuticals such as Fluoxetine (Prozac). It is used as a chemical reagent in several industrial processes such as oil refinery. It is also used as etchant, cleaning agent, and a reagent to dissolve oxides and silicates.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Hydrogen fluoride (DB11072)
- Weight
- Average: 20.0063
Monoisotopic: 20.006228237 - Chemical Formula
- FH
- Synonyms
- fluorure d'hydrogène
- Fluorwasserstoff
- Hydrofluoric acid
- Hydrogen fluoride, anhydrous
- Hydrogenfluorid
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to prevent Dental decay Combination Product in combination with: Sodium fluoride (DB09325) ••• ••• •••• •••• •••••••••• Used in combination to treat Dental decay Combination Product in combination with: Sodium fluoride (DB09325) •••••••••••• •••••••• ••••• •••• •••• •••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Take separate from meals. Avoid eating or drinking for at least 30 minutes after applying hydrogen fluoride oral dental gel.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Fluoride ion ionic Q80VPU408O 16984-48-8 KRHYYFGTRYWZRS-UHFFFAOYSA-M - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Henry Schein Topical Fluoride Cream Cream 0.62 % Oral Abj Custom Packaging 1997-08-19 2001-09-27 Canada 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Acidulated Phosphate Fluoride Oral Solution Hydrogen fluoride (.017 %) + Sodium fluoride (.65 %) Solution Dental Pdt Image Inc. Dba Pro Dentec Canada 1995-12-31 1999-07-30 Canada All Solutions Acidulated Phosphate Fluoride Foam Hydrogen fluoride (0.06 %) + Sodium fluoride (2.59 %) Solution Dental Dentsply Professional 2006-04-06 2008-06-20 Canada Butler Protect One Minute Apf Fluoride Gel Hydrogen fluoride (0.17 %) + Phosphoric acid (1.31 %) + Sodium fluoride (1.23 %) Gel Topical John O. Butler Company 2004-03-10 2009-07-09 Canada Henry Schein Minute Topical Fluoride Gel Hydrogen fluoride (0.5 %) + Phosphoric acid (1.1 %) + Sodium fluoride (1.7 %) Gel Dental Abj Custom Packaging Not applicable Not applicable Canada Henry Schein Minute Topical Foam Fluoride Hydrogen fluoride (0.5 %) + Sodium fluoride (1.69 %) Aerosol Dental Abj Custom Packaging Not applicable Not applicable Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Alpha-Pro Hydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g) Gel Dental Dental Technologies, Inc. 2013-04-01 Not applicable US 
Alpha-Pro Hydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g) Gel Dental Dental Technologies, Inc. 2013-04-01 Not applicable US Denti-Care Topical Fluoride Foam Bubble Gum Hydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g) Aerosol, foam Dental Ar Medicom Inc. 2011-02-09 Not applicable US Denti-Care Topical Fluoride Foam Grape Hydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g) Aerosol, foam Dental Ar Medicom Inc. 2003-05-01 Not applicable US Denti-Care Topical Fluoride Foam Orange Hydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g) Aerosol, foam Dental Ar Medicom Inc. 2003-05-01 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as halogen hydrides. These are inorganic compounds in which the heaviest atom bonded to a hydrogen atom is a halogen.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Halogen organides
- Sub Class
- Halogen hydrides
- Direct Parent
- Halogen hydrides
- Alternative Parents
- Inorganic hydrides
- Substituents
- Halogen hydride / Inorganic hydride
- Molecular Framework
- Not Available
- External Descriptors
- hydrogen halide, mononuclear parent hydride (CHEBI:29228)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- RGL5YE86CZ
- CAS number
- 7664-39-3
- InChI Key
- KRHYYFGTRYWZRS-UHFFFAOYSA-N
- InChI
- InChI=1S/FH/h1H
- IUPAC Name
- hydrogen fluoride
- SMILES
- F
References
- General References
- Not Available
- External Links
- KEGG Compound
- C16487
- PubChem Compound
- 14917
- PubChem Substance
- 347827885
- ChemSpider
- 14214
- 5496
- ChEBI
- 29228
- ChEMBL
- CHEMBL1232767
- Wikipedia
- Hydrofluoric_acid
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Dental Gel Dental Aerosol, foam Dental Cream Oral 0.62 % Aerosol Dental Liquid Topical Gel Topical Liquid Dental Disc Topical Liquid Dental; Oral Gel - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.15 Chemaxon pKa (Strongest Acidic) 3.17 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 1.67 m3·mol-1 Chemaxon Polarizability 0.79 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at April 26, 2024 00:45