Ciraparantag
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Ciraparantag
- DrugBank Accession Number
- DB15199
- Background
Ciraparantag is under investigation in clinical trial NCT01826266 (Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 512.708
Monoisotopic: 512.402318834 - Chemical Formula
- C22H48N12O2
- Synonyms
- Ciraparantag
- Ciraparantagum
- External IDs
- PER 977
- PER-977
- PER977
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U2R67KV65Q
- CAS number
- 1438492-26-2
- InChI Key
- HRDUUSCYRPOMSO-ROUUACIJSA-N
- InChI
- InChI=1S/C22H48N12O2/c23-17(5-1-7-31-21(25)26)19(35)29-9-3-11-33-13-15-34(16-14-33)12-4-10-30-20(36)18(24)6-2-8-32-22(27)28/h17-18H,1-16,23-24H2,(H,29,35)(H,30,36)(H4,25,26,31)(H4,27,28,32)/t17-,18-/m0/s1
- IUPAC Name
- (2S)-2-amino-N-[3-(4-{3-[(2S)-2-amino-5-carbamimidamidopentanamido]propyl}piperazin-1-yl)propyl]-5-carbamimidamidopentanamide
- SMILES
- N[C@@H](CCCNC(N)=N)C(=O)NCCCN1CCN(CCCNC(=O)[C@@H](N)CCCNC(N)=N)CC1
References
- General References
- Not Available
- External Links
- ChemSpider
- 33427375
- ChEMBL
- CHEMBL3544919
- Wikipedia
- Ciraparantag
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Other Anticoagulation Reversal 1 2 Completed Treatment Healthy Volunteers (HV) 2 2 Recruiting Treatment Healthy Volunteers (HV) 1 1 Completed Basic Science Healthy Volunteers (HV) 1 1 Completed Treatment Anticoagulant Reversal / Reversal of Edoxaban Induced Anticoagulation 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.19 mg/mL ALOGPS logP -1.6 ALOGPS logP -4.3 Chemaxon logS -3.4 ALOGPS pKa (Strongest Basic) 12.51 Chemaxon Physiological Charge 5 Chemaxon Hydrogen Acceptor Count 12 Chemaxon Hydrogen Donor Count 10 Chemaxon Polar Surface Area 240.52 Å2 Chemaxon Rotatable Bond Count 18 Chemaxon Refractivity 163.12 m3·mol-1 Chemaxon Polarizability 59.7 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 14:59 / Updated at February 21, 2021 18:55