Rilematovir
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Rilematovir
- DrugBank Accession Number
- DB15672
- Background
Rilematovir is under investigation in clinical trial NCT04056611 (Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial Virus (RSV)).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 500.92
Monoisotopic: 500.0896739 - Chemical Formula
- C21H20ClF3N4O3S
- Synonyms
- Rilematovir
- External IDs
- JNJ-53718678
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- NQ99E8OH3P
- CAS number
- 1383450-81-4
- InChI Key
- GTQTUABHRCWVLL-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3
- IUPAC Name
- 3-{[5-chloro-1-(3-methanesulfonylpropyl)-1H-indol-2-yl]methyl}-1-(2,2,2-trifluoroethyl)-1H,2H,3H-imidazo[4,5-c]pyridin-2-one
- SMILES
- CS(=O)(=O)CCCN1C(CN2C(=O)N(CC(F)(F)F)C3=C2C=NC=C3)=CC2=C1C=CC(Cl)=C2
References
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Terminated Treatment Respiratory Tract Infections (RTI) 1 2 Completed Treatment Respiratory Syncytial Virus (RSV) 1 2 Completed Treatment Respiratory Syncytial Virus (RSV) Infection 2 2 Terminated Treatment Respiratory Syncytial Virus (RSV) 1 2 Terminated Treatment Respiratory Syncytial Virus (RSV) Infection 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00415 mg/mL ALOGPS logP 3.16 ALOGPS logP 2.28 Chemaxon logS -5.1 ALOGPS pKa (Strongest Acidic) 17.85 Chemaxon pKa (Strongest Basic) 3.73 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 75.51 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 118.14 m3·mol-1 Chemaxon Polarizability 46.71 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at April 20, 2020 15:45 / Updated at February 21, 2021 18:55