Fonadelpar
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Fonadelpar
- DrugBank Accession Number
- DB16169
- Background
Fonadelpar is under investigation in clinical trial NCT03527212 (A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 504.52
Monoisotopic: 504.133062892 - Chemical Formula
- C25H23F3N2O4S
- Synonyms
- Fonadelpar
- External IDs
- NPS-005
- SJP-0035
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- FK5ZAD810Z
- CAS number
- 515138-06-4
- InChI Key
- WWKYLBGQYALEDL-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H23F3N2O4S/c1-13(2)23-21(35-24(29-23)15-4-6-16(7-5-15)25(26,27)28)9-8-18-17-10-14(3)19(33-12-22(31)32)11-20(17)34-30-18/h4-7,10-11,13H,8-9,12H2,1-3H3,(H,31,32)
- IUPAC Name
- 2-[(5-methyl-3-{2-[4-(propan-2-yl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]ethyl}-1,2-benzoxazol-6-yl)oxy]acetic acid
- SMILES
- CC(C)C1=C(CCC2=NOC3=CC(OCC(O)=O)=C(C)C=C23)SC(=N1)C1=CC=C(C=C1)C(F)(F)F
References
- General References
- Not Available
- External Links
- ChemSpider
- 8003203
- ChEMBL
- CHEMBL3545186
- ZINC
- ZINC000033974001
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Dry Eye Syndrome (DES) 1 2 Completed Treatment Corneal Epithelial Disorders 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00859 mg/mL ALOGPS logP 5.89 ALOGPS logP 6.43 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 3.93 Chemaxon pKa (Strongest Basic) 2.73 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 85.45 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 135.35 m3·mol-1 Chemaxon Polarizability 50.66 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 15, 2020 18:14 / Updated at February 21, 2021 18:55