ORY-1001
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- ORY-1001
- DrugBank Accession Number
- DB16848
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 244.382
Monoisotopic: 244.193948781 - Chemical Formula
- C16H24N2
- Synonyms
- Iadademstat
- External IDs
- RG-6016
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key ORY-1001 dihydrochloride G02YXY861Q 1431326-61-2 PWIVHEUJEJPRIZ-WCUAUJSVSA-N
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- XC0UT08SNJ
- CAS number
- 1401966-39-9
- InChI Key
- VHNNYAVEBXCOSG-DISOXQEGSA-N
- InChI
- InChI=1S/C16H24N2/c17-14-8-6-12(7-9-14)11-18-16-10-15(16)13-4-2-1-3-5-13/h1-5,12,14-16,18H,6-11,17H2/t12?,14?,15-,16+/m0/s1
- IUPAC Name
- 4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)cyclohexan-1-amine
- SMILES
- NC1CCC(CN[C@@H]2C[C@H]2C2=CC=CC=C2)CC1
References
- General References
- Not Available
- External Links
- ChemSpider
- 81368501
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Recruiting Treatment Neuroendocrine Carcinomas (NEC) / Small Cell Lung Cancer (SCLC) 1 1 Not Yet Recruiting Treatment Acute Myeloid Leukemia / Acute Myeloid Leukemia (AML)/Myelodysplastic Syndrome (MDS) 1 1 Recruiting Treatment Refractory Acute Myeloid Leukemia (AML) / Relapsed Acute Myelogenous Leukemia (AML) 1 1, 2 Not Yet Recruiting Treatment Extensive-stage Small Cell Lung Cancer (SCLC) / Stage IV Lung Cancer AJCC v8 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0115 mg/mL ALOGPS logP 2.47 ALOGPS logP 2.39 Chemaxon logS -4.3 ALOGPS pKa (Strongest Basic) 10.63 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 38.05 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 75.54 m3·mol-1 Chemaxon Polarizability 30.06 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0090000000-f02407689cdcfda3dd78 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-002f-0590000000-53c9664fbad746f22ef8 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0292-4930000000-769b916b86f5ac8d5d37 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0090000000-07afa0fc127b1983e35b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-052p-8920000000-c5c56015141017f7c183 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-01p6-3920000000-b99302955c16c95d7572 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at July 25, 2022 15:46 / Updated at May 02, 2024 16:20