This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- L-Acetylleucine
- DrugBank Accession Number
- DB16956
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for L-Acetylleucine (DB16956)
- Weight
- Average: 173.212
Monoisotopic: 173.105193347 - Chemical Formula
- C8H15NO3
- Synonyms
- (s)-2-acetamido-4-methylpentanoic acid
- Acetyl-l-leucine
- Acetylleucine, (s)-
- Acetylleucine, l-
- L-leucine, n-acetyl-
- Leucine, n-acetyl-, l-
- N-acetyl leucine
- N-acetyl-l-(-)-leucine
- N-acetyl-l-leucine
- N-Acetyl-Leucine
- N-acetylleucine
- External IDs
- NSC-206316
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Brand name Granule, for solution 1000 mg/1 Oral IntraBio Inc 2024-01-18 Not applicable US 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Brand name L-Acetylleucine (1000 mg/1) Granule, for solution Oral IntraBio Inc 2024-01-18 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- E915HL7K2O
- CAS number
- 1188-21-2
- InChI Key
- WXNXCEHXYPACJF-ZETCQYMHSA-N
- InChI
- InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
- IUPAC Name
- (2S)-2-acetamido-4-methylpentanoic acid
- SMILES
- CC(C)C[C@H](NC(C)=O)C(O)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0011756
- KEGG Compound
- C02710
- ChemSpider
- 64075
- 2375522
- ChEBI
- 17786
- ChEMBL
- CHEMBL56021
- ZINC
- ZINC000000135384
- PDBe Ligand
- LAY
- PDB Entries
- 5afg / 5nfu
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Treatment Vasovagal Syncope 1 4 Completed Not Available Healthy Volunteers (HV) 1 4 Completed Not Available Migraine 1 4 Completed Not Available Pill Capsule Endoscopy Completion Rates 1 4 Completed Basic Science Blood Pressures 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Granule, for solution Oral 1000 mg/1 - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 10.9 mg/mL ALOGPS logP 0.78 ALOGPS logP 0.49 Chemaxon logS -1.2 ALOGPS pKa (Strongest Acidic) 4.2 Chemaxon pKa (Strongest Basic) -1.8 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 66.4 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 43.61 m3·mol-1 Chemaxon Polarizability 18.07 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 14, 2022 22:04 / Updated at December 01, 2022 11:33