NAV

LY-2183240

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
LY-2183240
DrugBank Accession Number
DB17035
Background

LY-2183240 is an inhibitor of endocannabinoid reuptake/breakdown.1

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 307.357
Monoisotopic: 307.143310187
Chemical Formula
C17H17N5O
Synonyms
  • 1h-tetrazole-1-carboxamide, 5-((1,1'-biphenyl)-4-ylmethyl)-n,n-dimethyl-
  • 5-(biphenyl-4-ylmethyl)-n,n-dimethyl-1h-tetrazole-1-carboxamide
External IDs
  • LY-2183240
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
2WBU91OKM7
CAS number
874902-19-9
InChI Key
GZNIYOXWFCDBBJ-UHFFFAOYSA-N
InChI
InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
IUPAC Name
5-({[1,1'-biphenyl]-4-yl}methyl)-N,N-dimethyl-1H-1,2,3,4-tetrazole-1-carboxamide
SMILES
CN(C)C(=O)N1N=NN=C1CC1=CC=C(C=C1)C1=CC=CC=C1

References

General References
  1. Sun L, Tai L, Qiu Q, Mitchell R, Fleetwood-Walker S, Joosten EA, Cheung CW: Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814. doi: 10.1002/ejp.983. Epub 2017 Jan 20. [Article]
ChemSpider
9682599
BindingDB
26736
ChEBI
92670
ChEMBL
CHEMBL509860
ZINC
ZINC000013813297
Wikipedia
LY-2183240

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0615 mg/mLALOGPS
logP2.44ALOGPS
logP2.27Chemaxon
logS-3.7ALOGPS
pKa (Strongest Basic)-2.6Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area63.91 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity90.36 m3·mol-1Chemaxon
Polarizability32.64 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 17:28 / Updated at December 01, 2022 11:34