This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Acoramidis
- DrugBank Accession Number
- DB17999
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Acoramidis (DB17999)
- Weight
- Average: 292.31
Monoisotopic: 292.122320578 - Chemical Formula
- C15H17FN2O3
- Synonyms
- 3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid
- Acoramidis
- External IDs
- AG-10
- AG10
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- T12B44A1OE
- CAS number
- 1446711-81-4
- InChI Key
- WBFUHHBPNXWNCC-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
- IUPAC Name
- 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid
- SMILES
- CC1=C(CCCOC2=CC(=CC=C2F)C(O)=O)C(C)=NN1
References
- General References
- Not Available
- External Links
- ChemSpider
- 35033544
- BindingDB
- 50197885
- ChEMBL
- CHEMBL3940890
- ZINC
- ZINC000098207925
- PDBe Ligand
- 16V
- PDB Entries
- 4hiq
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Treatment Amyloid Cardiomyopathy, Transthyretin-Related 1 3 Active Not Recruiting Treatment Symptomatic Transthyretin Amyloid Cardiomyopathy 1 3 Completed Treatment Amyloid Cardiomyopathy / Amyloidosis / Cardiomyopathy / Cardiovascular Disease (CVD) / Transthyretin Amyloidosis 1 3 Withdrawn Treatment Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy 1 1 Completed Basic Science Healthy Volunteers (HV) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 2.14 Chemaxon pKa (Strongest Acidic) 4.27 Chemaxon pKa (Strongest Basic) 3.67 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 75.21 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 77.39 m3·mol-1 Chemaxon Polarizability 29.99 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at August 10, 2023 22:34 / Updated at September 12, 2023 18:32