This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Zapnometinib
- DrugBank Accession Number
- DB18244
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Zapnometinib (DB18244)
- Weight
- Average: 409.56
Monoisotopic: 408.91781 - Chemical Formula
- C13H7ClF2INO2
- Synonyms
- Benzoic acid, 2-((2-chloro-4-iodophenyl)amino)-3,4-difluoro-
- External IDs
- ATR-002
- PD-0184264
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4RZD8LK83V
- CAS number
- 303175-44-2
- InChI Key
- XCNBGWKQXRQKSA-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20)
- IUPAC Name
- 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluorobenzoic acid
- SMILES
- OC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1Cl
References
- General References
- Not Available
- External Links
- ChemSpider
- 8287717
- ChEMBL
- CHEMBL481949
- ZINC
- ZINC000022054634
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Terminated Treatment Coronavirus Disease 2019 (COVID‑19) 1 1 Completed Other Healthy Volunteers (HV) 1 1 Completed Treatment Flu caused by Influenza 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 6.19 Chemaxon pKa (Strongest Acidic) 3.77 Chemaxon pKa (Strongest Basic) -2.5 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 49.33 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 80.4 m3·mol-1 Chemaxon Polarizability 30.42 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 15, 2023 14:08 / Updated at September 17, 2023 04:15