Disintegrin and metalloproteinase domain-containing protein 10
Details
- Name
- Disintegrin and metalloproteinase domain-containing protein 10
- Synonyms
- 3.4.24.81
- ADAM 10
- CDw156
- KUZ
- Kuzbanian protein homolog
- MADM
- Mammalian disintegrin-metalloprotease
- Gene Name
- ADAM10
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004722|Disintegrin and metalloproteinase domain-containing protein 10 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL KRRRPPQPIQQPQRQRPRESYQMGHMRR
- Number of residues
- 748
- Molecular Weight
- 84141.515
- Theoretical pI
- 7.81
- GO Classification
- Functionsendopeptidase activity / integrin binding / metalloendopeptidase activity / metallopeptidase activity / protein homodimerization activity / protein kinase binding / receptor binding / zinc ion bindingProcessesaxon guidance / cell-cell signaling / collagen catabolic process / constitutive protein ectodomain proteolysis / ephrin receptor signaling pathway / epidermal growth factor receptor signaling pathway / extracellular matrix disassembly / extracellular matrix organization / in utero embryonic development / integrin-mediated signaling pathway / membrane protein ectodomain proteolysis / monocyte activation / negative regulation of cell adhesion / Notch receptor processing / Notch signaling pathway / PMA-inducible membrane protein ectodomain proteolysis / positive regulation of cell growth / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of T cell chemotaxis / protein phosphorylation / response to tumor necrosis factorComponentscell surface / cytoplasm / extracellular exosome / focal adhesion / Golgi apparatus / Golgi-associated vesicle / integral component of membrane / intracellular membrane-bounded organelle / membrane / nucleus / perinuclear endoplasmic reticulum / plasma membrane / postsynaptic density / tetraspanin-enriched microdomain
- General Function
- Zinc ion binding
- Specific Function
- Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
- Pfam Domain Function
- Transmembrane Regions
- 673-693
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020611|Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) ATGGTGTTGCTGAGAGTGTTAATTCTGCTCCTCTCCTGGGCGGCGGGGATGGGAGGTCAG TATGGGAATCCTTTAAATAAATATATCAGACATTATGAAGGATTATCTTACAATGTGGAT TCATTACACCAAAAACACCAGCGTGCCAAAAGAGCAGTCTCACATGAAGACCAATTTTTA CGTCTAGATTTCCATGCCCATGGAAGACATTTCAACCTACGAATGAAGAGGGACACTTCC CTTTTCAGTGATGAATTTAAAGTAGAAACATCAAATAAAGTACTTGATTATGATACCTCT CATATTTACACTGGACATATTTATGGTGAAGAAGGAAGTTTTAGCCATGGGTCTGTTATT GATGGAAGATTTGAAGGATTCATCCAGACTCGTGGTGGCACATTTTATGTTGAGCCAGCA GAGAGATATATTAAAGACCGAACTCTGCCATTTCACTCTGTCATTTATCATGAAGATGAT ATTAACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAA AGAATGAGGAAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAA CATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACAACTTCAGCTGAAAAAAAT ACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACGAGAA GCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACA GACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAATCAATACAACT GCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTT CTGGAATTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGAC CGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGAGCACCTTCAGGAAGCTCT GGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACT GGAATTATTACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACT TTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGATTCTGGAACAGAGTGCACA CCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGCAAGA GCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATA AGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCAACCTATTTGT GGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAA GATGAATGCTGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGG AAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAGTGTGCATTCAAGTCAAAG TCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACA GCTCTCTGCCCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAA GTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAATATGGCTTAGAGGAGTGT ACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTATGAAG AAAATGGACCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGT GGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGATTTTAGAGGTTACTGTGAT GTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCA ATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCA GTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGATTTATTAAGATATGCAGT GTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTA AAGAGGAGGAGACCTCCACAGCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAGAGAGT TATCAAATGGGACACATGAGACGCTAA
- Chromosome Location
- 15
- Locus
- 15q2|15q22
- External Identifiers
Resource Link UniProtKB ID O14672 UniProtKB Entry Name ADA10_HUMAN GenBank Gene ID AF009615 GenAtlas ID ADAM10 HGNC ID HGNC:188 - General References
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