Heparan sulfate glucosamine 3-O-sulfotransferase 1
Details
- Name
- Heparan sulfate glucosamine 3-O-sulfotransferase 1
- Synonyms
- 2.8.2.23
- 3-OST-1
- 3OST
- 3OST1
- h3-OST-1
- Heparan sulfate 3-O-sulfotransferase 1
- Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
- Gene Name
- HS3ST1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017438|Heparan sulfate glucosamine 3-O-sulfotransferase 1 MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIII GVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKT PAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVR DGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQ INASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELV GRTFDWH
- Number of residues
- 307
- Molecular Weight
- 35772.77
- Theoretical pI
- Not Available
- GO Classification
- Functions[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity / sulfotransferase activityProcessescarbohydrate metabolic process / glycosaminoglycan biosynthetic process / glycosaminoglycan metabolic process / small molecule metabolic processComponentsGolgi lumen / integral component of membrane
- General Function
- Sulfotransferase activity
- Specific Function
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
- Pfam Domain Function
- Sulfotransfer_1 (PF00685)
- Transmembrane Regions
- Not Available
- Cellular Location
- Golgi apparatus lumen
- Gene sequence
>lcl|BSEQ0017439|Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1) ATGGCCGCGCTGCTCCTGGGCGCGGTGCTGCTGGTGGCCCAGCCCCAGCTAGTGCCTTCC CGCCCCGCCGAGCTAGGCCAGCAGGAGCTTCTGCGGAAAGCGGGGACCCTCCAGGATGAC GTCCGCGATGGCGTGGCCCCAAACGGCTCTGCCCAGCAGTTGCCGCAGACCATCATCATC GGCGTGCGCAAGGGCGGCACGCGCGCACTGCTGGAGATGCTCAGCCTGCACCCCGACGTG GCGGCCGCGGAGAACGAGGTCCACTTCTTCGACTGGGAGGAGCATTACAGCCACGGCTTG GGCTGGTACCTCAGCCAGATGCCCTTCTCCTGGCCACACCAGCTCACAGTGGAGAAGACC CCCGCGTATTTCACGTCGCCCAAAGTGCCTGAGCGAGTCTACAGCATGAACCCGTCCATC CGGCTGCTGCTCATCCTGCGAGACCCGTCGGAGCGCGTGCTATCTGACTACACCCAAGTG TTCTACAACCACATGCAGAAGCACAAGCCCTACCCGTCCATCGAGGAGTTCCTGGTGCGC GATGGCAGGCTCAATGTGGACTACAAGGCCCTCAACCGCAGCCTCTACCACGTGCACATG CAGAACTGGCTGCGCTTTTTCCCGCTGCGCCACATCCACATTGTGGACGGCGACCGCCTC ATCAGGGACCCCTTCCCTGAGATCCAAAAGGTCGAGAGGTTCCTAAAGCTGTCGCCGCAG ATCAATGCTTCGAACTTCTACTTTAACAAAACCAAGGGCTTTTACTGCCTGCGGGACAGC GGCCGGGACCGCTGCTTACATGAGTCCAAAGGCCGGGCGCACCCCCAAGTCGATCCCAAA CTACTCAATAAACTGCACGAATATTTTCATGAGCCAAATAAGAAGTTCTTCGAGCTTGTT GGCAGAACATTTGACTGGCACTGA
- Chromosome Location
- 4
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O14792 UniProtKB Entry Name HS3S1_HUMAN HGNC ID HGNC:5194 - General References
- Shworak NW, Liu J, Fritze LM, Schwartz JJ, Zhang L, Logeart D, Rosenberg RD: Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. J Biol Chem. 1997 Oct 31;272(44):28008-19. [Article]
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- Liu J, Shworak NW, Fritze LM, Edelberg JM, Rosenberg RD: Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. J Biol Chem. 1996 Oct 25;271(43):27072-82. [Article]
- Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD: Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. J Biol Chem. 1999 Feb 19;274(8):5185-92. [Article]
- Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD: Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem. 1999 Feb 19;274(8):5170-84. [Article]