Actin-related protein 2/3 complex subunit 3
Details
- Name
- Actin-related protein 2/3 complex subunit 3
- Synonyms
- ARC21
- Arp2/3 complex 21 kDa subunit
- p21-ARC
- Gene Name
- ARPC3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017380|Actin-related protein 2/3 complex subunit 3 MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEI KNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKP ANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ
- Number of residues
- 178
- Molecular Weight
- 20546.505
- Theoretical pI
- 8.83
- GO Classification
- Functionsstructural constituent of cytoskeletonProcessesArp2/3 complex-mediated actin nucleation / axon guidance / ephrin receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / innate immune response / movement of cell or subcellular component / small GTPase mediated signal transductionComponentsactin cytoskeleton / Arp2/3 protein complex / cytosol / extracellular exosome / focal adhesion / lamellipodium / membrane
- General Function
- Structural constituent of cytoskeleton
- Specific Function
- Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
- Pfam Domain Function
- P21-Arc (PF04062)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017381|Actin-related protein 2/3 complex subunit 3 (ARPC3) ATGCCGGCTTACCACTCTTCTCTCATGGATCCTGATACCAAACTCATCGGAAACATGGCA CTGTTGCCTATCAGAAGTCAATTCAAAGGACCTGCCCCCAGAGAGACAAAAGATACAGAT ATTGTGGATGAAGCCATCTATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATT AAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTCTGAATGTCTGAAG AAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATC ACTAATTTTCCCATTCCTGGAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCT GCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCTAAGGCAAGAGACT GGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGG ACTTGCTTTGTGAAGAGACAGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGA
- Chromosome Location
- 12
- Locus
- 12q24.11
- External Identifiers
Resource Link UniProtKB ID O15145 UniProtKB Entry Name ARPC3_HUMAN GenBank Protein ID 2209347 GenBank Gene ID AF004561 HGNC ID HGNC:706 - General References
- Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW: Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. Biochem J. 1997 Nov 15;328 ( Pt 1):105-12. [Article]
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