Kanamycin nucleotidyltransferase
Details
- Name
- Kanamycin nucleotidyltransferase
- Synonyms
- 2.7.7.-
- kan
- Neo(R)
- Gene Name
- knt
- Organism
- Staphylococcus aureus
- Amino acid sequence
>lcl|BSEQ0022440|Kanamycin nucleotidyltransferase MNGPIIMTREERMKIVHEIKERILDKYGDDVKAIGVYGSLGRQTDGPYSDIEMMCVMSTE EAEFSHEWTTGEWKVEVNFDSEEILLDYASQVESDWPLTHGQFFSILPIYDSGGYLEKVY QTAKSVEAQTFHDAICALIVEELFEYAGKWRNIRVQGPTTFLPSLTVQVAMAGAMLIGLH HRICYTTSASVLTEAVKQSDLPSGYDHLCQFVMSGQLSDSEKLLESLENFWNGIQEWTER HGYIVDVSKRIPF
- Number of residues
- 253
- Molecular Weight
- 28797.38
- Theoretical pI
- 4.44
- GO Classification
- Functionsnucleotidyltransferase activityProcessesresponse to antibiotic
- General Function
- Nucleotidyltransferase activity
- Specific Function
- Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
- Pfam Domain Function
- KNTase_C (PF07827)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006834|708 bp ATGAAACATGGCATTCAGTCACAAAAGGTTGTTGCTGAAGTTATTAAACAAAAGCCAACA GTTCGTTGGTTGTTTCTCACATTAACAGTTAAAAATGTTTATGATGGCGAAGAATTAAAT AAGAGTTTGTCAGATATGGCTCAAGGATTTCGCCGAATGATGCAATATAAAAAAATTAAT AAAAATCTTGTTGGTTTTATGCGTGCAACGGAAGTGACAATAAATAATAAAGATAATTCT TATAATCAGCACATGCATGTATTGGTATGTGTGGAACCAACTTATTTTAAGAATACAGAA AACTACGTGAATCAAAAACAATGGATTCAATTTTGGAAAAAGGCAATGAAATTAGACTAT GATCCAAATGTAAAAGTTCAAATGATTCGACCGAAAAATAAATATAAATCGGATATACAA TCGGCAATTGACGAAACTGCAAAATATCCTGTAAAGGATACGGATTTTATGACCGATGAT GAAGAAAAGAATTTGAAACGTTTGTCTGATTTGGAGGAAGGTTTACACCGTAAAAGGTTA ATCTCCTATGGTGGTTTGTTAAAAGAAATACATAAAAAATTAAACCTTGATGACACAGAA GAAGGCGATTTGATTCATACAGATGATGACGAAAAAGCCGATGAAGATGGATTTTCTATT ATTGCAATGTGGAATTGGGAACGGAAAAATTATTTTATTAAAGAGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P05057 UniProtKB Entry Name KANU_STAAU GenBank Protein ID 46496 GenBank Gene ID X03408 - General References
- Muller RE, Ano T, Imanaka T, Aiba S: Complete nucleotide sequences of Bacillus plasmids pUB110dB, pRBH1 and its copy mutants. Mol Gen Genet. 1986 Jan;202(1):169-71. [Article]
- Matsumura M, Katakura Y, Imanaka T, Aiba S: Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110. J Bacteriol. 1984 Oct;160(1):413-20. [Article]
- Bashkirov VI, Mil'shina NV, Prozorov AA: [Nucleotide sequence and physical map of kanamycin-resistant plasmid pUB110 from Staphylococcus aureus]. Genetika. 1986 Jul;22(7):1081-92. [Article]
- McKenzie T, Hoshino T, Tanaka T, Sueoka N: The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. Plasmid. 1986 Mar;15(2):93-103. [Article]
- McKenzie T, Hoshino T, Tanaka T, Sueoka N: Correction. A revision of the nucleotide sequence and functional map of pUB110. Plasmid. 1987 Jan;17(1):83-5. [Article]
- Sakon J, Liao HH, Kanikula AM, Benning MM, Rayment I, Holden HM: Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution. Biochemistry. 1993 Nov 16;32(45):11977-84. [Article]
- Pedersen LC, Benning MM, Holden HM: Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase. Biochemistry. 1995 Oct 17;34(41):13305-11. [Article]