Gastric inhibitory polypeptide

Details

Name
Gastric inhibitory polypeptide
Synonyms
  • GIP
  • Glucose-dependent insulinotropic polypeptide
  • Incretin hormone
Gene Name
GIP
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052780|Gastric inhibitory polypeptide
MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISD
YSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPA
KNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR
Number of residues
153
Molecular Weight
17107.37
Theoretical pI
Not Available
GO Classification
Functions
gastric inhibitory polypeptide receptor binding / glucagon receptor binding / hormone activity
Processes
adenylate cyclase-activating G protein-coupled receptor signaling pathway / adult locomotory behavior / digestive system development / endocrine pancreas development / exploration behavior / female pregnancy / gastric inhibitory peptide signaling pathway / long-term synaptic potentiation / memory / positive regulation of cAMP-mediated signaling / positive regulation of glucagon secretion / positive regulation of glucose transmembrane transport / positive regulation of insulin secretion / regulation of fatty acid biosynthetic process / regulation of insulin secretion / response to acidic pH / response to amino acid / response to axon injury / response to glucose / response to lipid / response to organic cyclic compound / response to peptide hormone / response to selenium ion / response to starvation / response to xenobiotic stimulus / sensory perception of pain / signal transduction / triglyceride homeostasis
Components
endoplasmic reticulum lumen / extracellular region / extracellular space / neuronal cell body / secretory granule lumen
General Function
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Specific Function
Gastric inhibitory polypeptide receptor binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0052781|Gastric inhibitory polypeptide (GIP)
ATGGTGGCCACGAAGACCTTTGCTCTGCTGCTGCTGTCCCTGTTCCTGGCAGTGGGACTA
GGAGAGAAGAAAGAGGGTCACTTCAGCGCTCTCCCCTCCCTGCCTGTTGGATCTCATGCT
AAGGTGAGCAGCCCTCAACCTCGAGGCCCCAGGTACGCGGAAGGGACTTTCATCAGTGAC
TACAGTATTGCCATGGACAAGATTCACCAACAAGACTTTGTGAACTGGCTGCTGGCCCAA
AAGGGGAAGAAGAATGACTGGAAACACAACATCACCCAGAGGGAGGCTCGGGCGCTGGAG
CTGGCCAGTCAAGCTAATAGGAAGGAGGAGGAGGCAGTGGAGCCACAGAGCTCCCCAGCC
AAGAACCCCAGCGATGAAGATTTGCTGCGGGACTTGCTGATTCAAGAGCTGTTGGCCTGC
TTGCTGGATCAGACAAACCTCTGCAGGCTCAGGTCTCGGTGA
Chromosome Location
17
Locus
17q21.32
External Identifiers
ResourceLink
UniProtKB IDP09681
UniProtKB Entry NameGIP_HUMAN
HGNC IDHGNC:4270
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB15171Tirzepatideapproved, investigationalyesagonistDetails