High-molecular-weight cytochrome c
Details
- Name
- High-molecular-weight cytochrome c
- Synonyms
- Cytochrome CC3
- hmc
- Gene Name
- hmcA
- Organism
- Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
- Amino acid sequence
>lcl|BSEQ0003468|High-molecular-weight cytochrome c MRNGRTLLRWAGVLAATAIIGVGGFWSQGTTKALPEGPGEKRADLIEIGAMERFGKLDLP KVAFRHDQHTTAVTGMGKDCAACHKSKDGKMSLKFMRLDDNSAAELKEIYHANCIGCHTD LAKAGKKTGPQDGECRSCHNPKPSAASSWKEIGFDKSLHYRHVASKAIKPVGDPQKNCGA CHHVYDEASKKLVWGKNKEDSCRACHGEKPVDKRPALDTAAHTACISCHMDVAKTKAETG PVNCAGCHAPEAQAKFKVVREVPRLDRGQPDAALILPVPGKDAPREMKGTMKPVAFDHKA HEAKANDCRTCHHVRIDTCTACHTVNGTADSKFVQLEKAMHQPDSMRSCVGCHNTRVQQP TCAGCHGFIKPTKSDAQCGVCHVAAPGFDAKQVEAGALLNLKAEQRSQVAASMLSARPQP KGTFDLNDIPEKVVIGSIAKEYQPSEFPHRKIVKTLIAGIGEDKLAATFHIEKGTLCQGC HHNSPASLTPPKCASCHGKPFDADRGDRPGLKAAYHQQCMGCHDRMKIEKPANTACVDCH KERAK
- Number of residues
- 545
- Molecular Weight
- 58901.06
- Theoretical pI
- 8.67
- GO Classification
- Functionselectron carrier activity / heme binding / metal ion bindingProcessesoxidation-reduction processComponentsperiplasmic space
- General Function
- Metal ion binding
- Specific Function
- HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates.
- Pfam Domain Function
- Cytochrom_CIII (PF02085)
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0020565|High-molecular-weight cytochrome c (hmcA) ATGTCTGAGGATGTGTATCACCCATTCTTCCAAAGGACTGCCACTATGAGGAACGGAAGG ACACTGCTGCGATGGGCGGGAGTGTTGGCTGCCACCGCCATCATCGGCGTCGGCGGTTTC TGGTCACAGGGGACGACCAAGGCCCTCCCCGAAGGGCCGGGCGAAAAACGCGCCGACCTG ATCGAGATCGGGGCCATGGAACGCTTCGGGAAGCTTGATCTTCCCAAGGTGGCGTTCCGC CACGACCAGCACACCACCGCCGTGACGGGCATGGGCAAGGACTGCGCCGCCTGTCACAAG AGCAAGGACGGCAAGATGTCGCTGAAGTTCATGCGGCTTGACGACAACAGCGCCGCTGAA CTCAAGGAAATCTACCACGCCAACTGTATCGGCTGTCATACCGACCTCGCCAAGGCCGGT AAGAAGACCGGCCCGCAGGACGGCGAATGCCGCTCGTGCCACAACCCGAAGCCCTCTGCC GCCTCGTCGTGGAAGGAGATAGGCTTCGACAAGTCGCTGCACTACCGTCACGTGGCGTCC AAGGCCATCAAGCCCGTGGGCGACCCGCAGAAGAACTGCGGCGCTTGCCACCACGTCTAT GACGAAGCTTCCAAGAAGCTCGTATGGGGTAAGAACAAGGAAGACTCGTGCCGCGCCTGT CACGGCGAGAAGCCCGTGGACAAGCGTCCCGCGCTCGACACCGCCGCCCACACCGCGTGC ATCAGCTGCCACATGGACGTCGCCAAGACCAAGGCCGAGACCGGCCCGGTCAACTGCGCC GGCTGCCACGCCCCCGAGGCGCAGGCCAAGTTCAAGGTGGTACGCGAAGTGCCCCGCCTC GACCGCGGTCAGCCCGACGCCGCCCTCATCCTGCCCGTACCCGGCAAGGATGCCCCGCGC GAGATGAAGGGCACCATGAAGCCGGTCGCCTTCGACCACAAGGCCCACGAAGCCAAGGCC AACGACTGCCGCACCTGCCACCATGTGCGCATCGACACCTGCACCGCCTGCCATACCGTG AACGGTACCGCAGACAGCAAGTTCGTCCAGCTTGAAAAGGCCATGCACCAGCCCGACTCC ATGCGCAGCTGCGTGGGTTGTCACAACACCCGCGTCCAGCAGCCCACCTGTGCCGGTTGC CACGGCTTCATCAAGCCCACGAAGAGCGATGCCCAGTGCGGCGTGTGCCACGTGGCCGCC CCCGGCTTCGACGCCAAGCAGGTCGAAGCGGGCGCATTGCTGAACCTCAAGGCAGAGCAG CGTTCGCAGGTTGCCGCCTCCATGCTGTCGGCCCGTCCGCAGCCCAAGGGCACCTTCGAC CTCAATGACATCCCCGAAAAGGTCGTCATCGGCTCCATCGCCAAGGAATACCAGCCCAGC GAGTTCCCGCACCGCAAGATCGTGAAGACGCTCATCGCCGGTATCGGTGAAGACAAGCTG GCCGCCACCTTCCACATCGAGAAGGGCACGCTGTGCCAGGGCTGCCACCACAACAGCCCC GCCAGCCTCACCCCGCCCAAATGCGCGAGCTGCCACGGCAAGCCCTTCGACGCCGACAGG GGCGACCGTCCCGGTCTCAAGGCCGCCTACCACCAGCAGTGCATGGGCTGCCACGACCGG ATGAAGATCGAAAAGCCGGCGAACACCGCCTGCGTCGATTGCCACAAGGAACGCGCGAAA TAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P24092 UniProtKB Entry Name HMWC_DESVH GenBank Protein ID 145081 GenBank Gene ID M63807 - General References
- Pollock WB, Loutfi M, Bruschi M, Rapp-Giles BJ, Wall JD, Voordouw G: Cloning, sequencing, and expression of the gene encoding the high-molecular-weight cytochrome c from Desulfovibrio vulgaris Hildenborough. J Bacteriol. 1991 Jan;173(1):220-8. [Article]
- Heidelberg JF, Seshadri R, Haveman SA, Hemme CL, Paulsen IT, Kolonay JF, Eisen JA, Ward N, Methe B, Brinkac LM, Daugherty SC, Deboy RT, Dodson RJ, Durkin AS, Madupu R, Nelson WC, Sullivan SA, Fouts D, Haft DH, Selengut J, Peterson JD, Davidsen TM, Zafar N, Zhou L, Radune D, Dimitrov G, Hance M, Tran K, Khouri H, Gill J, Utterback TR, Feldblyum TV, Wall JD, Voordouw G, Fraser CM: The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough. Nat Biotechnol. 2004 May;22(5):554-9. Epub 2004 Apr 11. [Article]
- Tan JA, Cowan JA: Coordination and redox properties of a novel triheme cytochrome from Desulfovibrio vulgaris (Hildenborough). Biochemistry. 1990 May 22;29(20):4886-92. [Article]
- Bruschi M, Bertrand P, More C, Leroy G, Bonicel J, Haladjian J, Chottard G, Pollock WB, Voordouw G: Biochemical and spectroscopic characterization of the high molecular weight cytochrome c from Desulfovibrio vulgaris Hildenborough expressed in Desulfovibrio desulfuricans G200. Biochemistry. 1992 Mar 31;31(12):3281-8. [Article]
- Rossi M, Pollock WB, Reij MW, Keon RG, Fu R, Voordouw G: The hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough encodes a potential transmembrane redox protein complex. J Bacteriol. 1993 Aug;175(15):4699-711. [Article]
- Verhagen MF, Pierik AJ, Wolbert RB, Mallee LF, Voorhorst WG, Hagen WR: Axial coordination and reduction potentials of the sixteen hemes in high-molecular-mass cytochrome c from Desulfovibrio vulgaris (Hildenborough). Eur J Biochem. 1994 Oct 1;225(1):311-9. [Article]
- Matias PM, Coelho AV, Valente FM, Placido D, LeGall J, Xavier AV, Pereira IA, Carrondo MA: Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer. J Biol Chem. 2002 Dec 6;277(49):47907-16. Epub 2002 Sep 27. [Article]