Thiazole tautomerase
Details
- Name
- Thiazole tautomerase
- Synonyms
- 5.3.99.10
- Gene Name
- tenI
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0016476|Thiazole tautomerase MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILKLLDLIFEGGIDKRKLV MNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVHSLEEAVQAEKEDADYVLF GHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPDRLRDVKQAGADGIAVMSGIF SSAEPLEAARRYSRKLKEMRYEKAL
- Number of residues
- 205
- Molecular Weight
- 22928.24
- Theoretical pI
- 8.49
- GO Classification
- Functionsisomerase activity / thiamine-phosphate diphosphorylase activityProcessesthiamine biosynthetic process / thiamine diphosphate biosynthetic process
- General Function
- Thiamine-phosphate diphosphorylase activity
- Specific Function
- Catalyzes the irreversible aromatization of 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate (cThz*-P) to 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate (cThz-P), a step in the biosynthesis of the thiazole phosphate moiety of thiamine. Cannot use cThz* as substrate, indicating that the phosphate group is essential. Has no thiamine phosphate synthase activity, despite a high sequence similarity with ThiE.
- Pfam Domain Function
- TMP-TENI (PF02581)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016477|Thiazole tautomerase (tenI) GTGGAGCTTCACGCCATAACGGATGACAGCAAGCCGGTAGAAGAGCTAGCGAGAATCATC ATTACGATTCAGAATGAAGTTGATTTTATTCACATTCGGGAACGCTCAAAATCGGCGGCG GATATTTTGAAACTGCTCGATCTTATTTTTGAAGGCGGTATAGATAAACGAAAATTGGTG ATGAACGGGCGCGTGGATATTGCACTTTTCTCTACTATTCACCGCGTGCAGCTGCCAAGC GGCAGCTTTTCACCGAAGCAGATCAGAGCCAGATTTCCACACCTTCATATCGGGAGGTCG GTGCATTCACTGGAGGAAGCGGTTCAAGCAGAAAAGGAAGACGCGGACTACGTGCTGTTC GGCCATGTGTTTGAAACGGATTGCAAAAAGGGTCTTGAAGGCAGAGGAGTATCTTTGCTG TCAGATATCAAACAGCGGATTTCCATCCCGGTTATAGCCATCGGGGGGATGACGCCGGAC AGGTTAAGAGACGTAAAACAAGCAGGGGCAGACGGCATTGCTGTTATGTCAGGAATTTTC TCTTCCGCTGAACCTTTGGAAGCAGCCAGACGATATTCCCGCAAGCTAAAGGAGATGCGC TATGAAAAGGCATTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25053 UniProtKB Entry Name TENI_BACSU GenBank Gene ID M73546 - General References
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