ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Details
- Name
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- Synonyms
- 2'-phospho-ADP-ribosyl cyclase
- 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
- 2'-phospho-cyclic-ADP-ribose transferase
- 3.2.2.6
- ADP-ribosyl cyclase 1
- ADPRC 1
- cADPr hydrolase 1
- Cyclic ADP-ribose hydrolase 1
- T10
- Gene Name
- CD38
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009207|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
- Number of residues
- 300
- Molecular Weight
- 34328.145
- Theoretical pI
- Not Available
- GO Classification
- FunctionsNAD(P)+ nucleosidase activity / NAD+ nucleosidase activity / phosphorus-oxygen lyase activity / transferase activityProcessesapoptotic signaling pathway / B cell receptor signaling pathway / female pregnancy / long term synaptic depression / negative regulation of apoptotic process / negative regulation of bone resorption / negative regulation of transcription, DNA-templated / positive regulation of B cell proliferation / positive regulation of cell growth / positive regulation of cytosolic calcium ion concentration / positive regulation of insulin secretion / positive regulation of transcription, DNA-templated / positive regulation of vasoconstriction / response to drug / response to estradiol / response to hydroperoxide / response to hypoxia / response to interleukin-1 / response to progesterone / response to retinoic acid / signal transductionComponentscell surface / cytosol / extracellular exosome / integral component of membrane / membrane / nucleus / plasma membrane
- General Function
- Transferase activity
- Specific Function
- Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
- Pfam Domain Function
- Rib_hydrolayse (PF02267)
- Transmembrane Regions
- 22-42
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0013673|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) ATGGCCAACTGCGAGTTCAGCCCGGTGTCCGGGGACAAACCCTGCTGCCGGCTCTCTAGG AGAGCCCAACTCTGTCTTGGCGTCAGTATCCTGGTCCTGATCCTCGTCGTGGTGCTCGCG GTGGTCGTCCCGAGGTGGCGCCAGCAGTGGAGCGGTCCGGGCACCACCAAGCGCTTTCCC GAGACCGTCCTGGCGCGATGCGTCAAGTACACTGAAATTCATCCTGAGATGAGACATGTA GACTGCCAAAGTGTATGGGATGCTTTCAAGGGTGCATTTATTTCAAAACATCCTTGCAAC ATTACTGAAGAAGACTATCAGCCACTAATGAAGTTGGGAACTCAGACCGTACCTTGCAAC AAGATTCTTCTTTGGAGCAGAATAAAAGATCTGGCCCATCAGTTCACACAGGTCCAGCGG GACATGTTCACCCTGGAGGACACGCTGCTAGGCTACCTTGCTGATGACCTCACATGGTGT GGTGAATTCAACACTTCCAAAATAAACTATCAATCTTGCCCAGACTGGAGAAAGGACTGC AGCAACAACCCTGTTTCAGTATTCTGGAAAACGGTTTCCCGCAGGTTTGCAGAAGCTGCC TGTGATGTGGTCCATGTGATGCTCAATGGATCCCGCAGTAAAATCTTTGACAAAAACAGC ACTTTTGGGAGTGTGGAAGTCCATAATTTGCAACCAGAGAAGGTTCAGACACTAGAGGCC TGGGTGATACATGGTGGAAGAGAAGATTCCAGAGACTTATGCCAGGATCCCACCATAAAA GAGCTGGAATCGATTATAAGCAAAAGGAATATTCAATTTTCCTGCAAGAATATCTACAGA CCTGACAAGTTTCTTCAGTGTGTGAAAAATCCTGAGGATTCATCTTGCACATCTGAGATC TGA
- Chromosome Location
- 4
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P28907 UniProtKB Entry Name CD38_HUMAN HGNC ID HGNC:1667 - General References
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