Ephrin type-A receptor 8
Details
- Name
- Ephrin type-A receptor 8
- Synonyms
- 2.7.10.1
- EEK
- EK3
- EPH- and ELK-related kinase
- EPH-like kinase 3
- HEK3
- KIAA1459
- Tyrosine-protein kinase receptor EEK
- Gene Name
- EPHA8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051758|Ephrin type-A receptor 8 MAPARGRLPPALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEV DESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKE TFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRG FYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEER DTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSA APAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDI TYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSD LSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEK DKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDT RTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHP PGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQR DVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS LDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFG LSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYW NMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPE SLRATATVSRCPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLG MVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLTSTQGPRRHL
- Number of residues
- 1005
- Molecular Weight
- 111001.57
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / GPI-linked ephrin receptor activityProcessesaxon guidance / cell adhesion / cellular response to follicle-stimulating hormone stimulus / ephrin receptor signaling pathway / neuron projection development / neuron remodeling / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase activity / protein autophosphorylation / regulation of cell adhesion / regulation of cell adhesion mediated by integrin / substrate-dependent cell migrationComponentsearly endosome membrane / integral component of plasma membrane / neuron projection / plasma membrane
- General Function
- Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- 543-563
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0051759|Ephrin type-A receptor 8 (EPHA8) ATGGCCCCCGCCCGGGGCCGCCTGCCCCCTGCGCTCTGGGTCGTCACGGCCGCGGCGGCG GCGGCCACCTGCGTGTCCGCGGCGCGCGGCGAAGTGAATTTGCTGGACACGTCGACCATC CACGGGGACTGGGGCTGGCTCACGTATCCGGCTCATGGGTGGGACTCCATCAACGAGGTG GACGAGTCCTTCCAGCCCATCCACACGTACCAGGTTTGCAACGTCATGAGCCCCAACCAG AACAACTGGCTGCGCACGAGCTGGGTCCCCCGAGACGGCGCCCGGCGCGTCTATGCTGAG ATCAAGTTTACCCTGCGCGACTGCAACAGCATGCCTGGTGTGCTGGGCACCTGCAAGGAG ACCTTCAACCTCTACTACCTGGAGTCGGACCGCGACCTGGGGGCCAGCACACAAGAAAGC CAGTTCCTCAAAATCGACACCATTGCGGCCGACGAGAGCTTCACAGGTGCCGACCTTGGT GTGCGGCGTCTCAAGCTCAACACGGAGGTGCGCAGTGTGGGTCCCCTCAGCAAGCGCGGC TTCTACCTGGCCTTCCAGGACATAGGTGCCTGCCTGGCCATCCTCTCTCTCCGCATCTAC TATAAGAAGTGCCCTGCCATGGTGCGCAATCTGGCTGCCTTCTCGGAGGCAGTGACGGGG GCCGACTCGTCCTCACTGGTGGAGGTGAGGGGCCAGTGCGTGCGGCACTCAGAGGAGCGG GACACACCCAAGATGTACTGCAGCGCGGAGGGCGAGTGGCTCGTGCCCATCGGCAAATGC GTGTGCAGTGCCGGCTACGAGGAGCGGCGGGATGCCTGTGTGGCCTGTGAGCTGGGCTTC TACAAGTCAGCCCCTGGGGACCAGCTGTGTGCCCGCTGCCCTCCCCACAGCCACTCCGCA GCTCCAGCCGCCCAAGCCTGCCACTGTGACCTCAGCTACTACCGTGCAGCCCTGGACCCG CCGTCCTCAGCCTGCACCCGGCCACCCTCGGCACCAGTGAACCTGATCTCCAGTGTGAAT GGGACATCAGTGACTCTGGAGTGGGCCCCTCCCCTGGACCCAGGTGGCCGCAGTGACATC ACCTACAATGCCGTGTGCCGCCGCTGCCCCTGGGCACTGAGCCGCTGCGAGGCATGTGGG AGCGGCACCCGCTTTGTGCCCCAGCAGACAAGCCTGGTGCAGGCCAGCCTGCTGGTGGCC AACCTGCTGGCCCACATGAACTACTCCTTCTGGATCGAGGCCGTCAATGGCGTGTCCGAC CTGAGCCCCGAGCCCCGCCGGGCCGCTGTGGTCAACATCACCACGAACCAGGCAGCCCCG TCCCAGGTGGTGGTGATCCGTCAAGAGCGGGCGGGGCAGACCAGCGTCTCGCTGCTGTGG CAGGAGCCCGAGCAGCCGAACGGCATCATCCTGGAGTATGAGATCAAGTACTACGAGAAG GACAAGGAGATGCAGAGCTACTCCACCCTCAAGGCCGTCACCACCAGAGCCACCGTCTCC GGCCTCAAGCCGGGCACCCGCTACGTGTTCCAGGTCCGAGCCCGCACCTCAGCAGGCTGT GGCCGCTTCAGCCAGGCCATGGAGGTGGAGACCGGGAAACCCCGGCCCCGCTATGACACC AGGACCATTGTCTGGATCTGCCTGACGCTCATCACGGGCCTGGTGGTGCTTCTGCTCCTG CTCATCTGCAAGAAGAGGCACTGTGGCTACAGCAAGGCCTTCCAGGACTCGGACGAGGAG AAGATGCACTATCAGAATGGACAGGCACCCCCACCTGTCTTCCTGCCTCTGCATCACCCC CCGGGAAAGCTCCCAGAGCCCCAGTTCTATGCGGAACCCCACACCTACGAGGAGCCAGGC CGGGCGGGCCGCAGTTTCACTCGGGAGATCGAGGCCTCTAGGATCCACATCGAGAAAATC ATCGGCTCTGGAGACTCCGGGGAAGTCTGCTACGGGAGGCTGCGGGTGCCAGGGCAGCGG GATGTGCCCGTGGCCATCAAGGCCCTCAAAGCCGGCTACACGGAGAGACAGAGGCGGGAC TTCCTGAGCGAGGCGTCCATCATGGGGCAATTCGACCATCCCAACATCATCCGCCTCGAG GGTGTCGTCACCCGTGGCCGCCTGGCAATGATTGTGACTGAGTACATGGAGAACGGCTCT CTGGACACCTTCCTGAGGACCCACGACGGGCAGTTCACCATCATGCAGCTGGTGGGCATG CTGAGAGGAGTGGGTGCCGGCATGCGCTACCTCTCAGACCTGGGCTATGTCCACCGAGAC CTGGCCGCCCGCAACGTCCTGGTTGACAGCAACCTGGTCTGCAAGGTGTCTGACTTCGGG CTCTCACGGGTGCTGGAGGACGACCCGGATGCTGCCTACACCACCACGGGCGGGAAGATC CCCATCCGCTGGACGGCCCCAGAGGCCATCGCCTTCCGCACCTTCTCCTCGGCCAGCGAC GTGTGGAGCTTCGGCGTGGTCATGTGGGAGGTGCTGGCCTATGGGGAGCGGCCCTACTGG AACATGACCAACCGGGATGTCATCAGCTCTGTGGAGGAGGGGTACCGCCTGCCCGCACCC ATGGGCTGCCCCCACGCCCTGCACCAGCTCATGCTCGACTGTTGGCACAAGGACCGGGCG CAGCGGCCTCGCTTCTCCCAGATTGTCAGTGTCCTCGATGCGCTCATCCGCAGCCCTGAG AGTCTCAGGGCCACCGCCACAGTCAGCAGGTGCCCACCCCCTGCCTTCGTCCGGAGCTGC TTTGACCTCCGAGGGGGCAGCGGTGGCGGTGGGGGCCTCACCGTGGGGGACTGGCTGGAC TCCATCCGCATGGGCCGGTACCGAGACCACTTCGCTGCGGGCGGATACTCCTCTCTGGGC ATGGTGCTACGCATGAACGCCCAGGACGTGCGCGCCCTGGGCATCACCCTCATGGGCCAC CAGAAGAAGATCCTGGGCAGCATTCAGACCATGCGGGCCCAGCTGACCAGCACCCAGGGG CCCCGCCGGCACCTCTGA
- Chromosome Location
- 1
- Locus
- 1p36.12
- External Identifiers
Resource Link UniProtKB ID P29322 UniProtKB Entry Name EPHA8_HUMAN HGNC ID HGNC:3391 - General References
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