Interferon gamma receptor 2
Details
- Name
- Interferon gamma receptor 2
- Synonyms
- AF-1
- IFN-gamma receptor 2
- IFNGT1
- Interferon gamma receptor accessory factor 1
- Interferon gamma transducer 1
- Gene Name
- IFNGR2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010328|Interferon gamma receptor 2 MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRP VVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELG ALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYW EKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMAD ASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQ PILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
- Number of residues
- 337
- Molecular Weight
- 37805.97
- Theoretical pI
- 5.35
- GO Classification
- Functionsinterferon-gamma receptor activityProcessescell surface receptor signaling pathway / cytokine-mediated signaling pathway / interferon-gamma-mediated signaling pathway / regulation of interferon-gamma-mediated signaling pathway / response to virusComponentsendoplasmic reticulum / integral component of plasma membrane / plasma membrane
- General Function
- Interferon-gamma receptor activity
- Specific Function
- Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
- Pfam Domain Function
- Transmembrane Regions
- 248-268
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010329|Interferon gamma receptor 2 (IFNGR2) ATGCGACCGACGCTGCTGTGGTCGCTGCTGCTGCTGCTCGGAGTCTTCGCCGCCGCCGCC GCGGCCCCGCCAGACCCTCTTTCCCAGCTGCCCGCTCCTCAGCACCCGAAGATTCGCCTG TACAACGCAGAGCAGGTCCTGAGTTGGGAGCCAGTGGCCCTGAGCAATAGCACGAGGCCT GTTGTCTACCAAGTGCAGTTTAAATACACCGACAGTAAATGGTTCACGGCCGACATCATG TCCATAGGGGTGAATTGTACACAGATCACAGCAACAGAGTGTGACTTCACTGCCGCCAGT CCCTCAGCAGGCTTCCCAATGGATTTCAATGTCACTCTACGCCTTCGAGCTGAGCTGGGA GCACTCCATTCTGCCTGGGTGACAATGCCTTGGTTTCAACACTATCGGAATGTGACTGTC GGGCCTCCAGAAAACATTGAGGTGACCCCAGGAGAAGGCTCCCTCATCATCAGGTTCTCC TCTCCCTTTGACATCGCTGATACCTCCACGGCCTTTTTTTGTTATTATGTCCATTACTGG GAAAAAGGAGGAATCCAACAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGAT AACTTAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAA AGTAACATCTTTAGAGTCGGGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGAT GCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCG GTGCTGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGG TTTCACACTCCACCAAGCATCCCATTACAGATAGAAGAGTATTTAAAAGACCCAACTCAG CCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCTGGGACTCTGTG TCCATTATCTCGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGA
- Chromosome Location
- 21
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P38484 UniProtKB Entry Name INGR2_HUMAN GenBank Protein ID 463550 GenBank Gene ID U05875 GenAtlas ID IFNGR2 HGNC ID HGNC:5440 - General References
- Soh J, Donnelly RJ, Kotenko S, Mariano TM, Cook JR, Wang N, Emanuel S, Schwartz B, Miki T, Pestka S: Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell. 1994 Mar 11;76(5):793-802. [Article]
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- Rhee S, Ebensperger C, Dembic Z, Pestka S: The structure of the gene for the second chain of the human interferon-gamma receptor. J Biol Chem. 1996 Nov 15;271(46):28947-52. [Article]
- Vogt G, Chapgier A, Yang K, Chuzhanova N, Feinberg J, Fieschi C, Boisson-Dupuis S, Alcais A, Filipe-Santos O, Bustamante J, de Beaucoudrey L, Al-Mohsen I, Al-Hajjar S, Al-Ghonaium A, Adimi P, Mirsaeidi M, Khalilzadeh S, Rosenzweig S, de la Calle Martin O, Bauer TR, Puck JM, Ochs HD, Furthner D, Engelhorn C, Belohradsky B, Mansouri D, Holland SM, Schreiber RD, Abel L, Cooper DN, Soudais C, Casanova JL: Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations. Nat Genet. 2005 Jul;37(7):692-700. Epub 2005 May 29. [Article]