2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Details

Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Synonyms
  • 2.7.6.3
  • 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
  • 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
  • HPPK
  • PPPK
Gene Name
folK
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Amino acid sequence
>lcl|BSEQ0011051|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MITAYIALGSNLNTPVEQLHAALKAISQLSNTHLVTTSSFYKSKPLGPQDQPDYVNAVAK
IETELSPLKLLDELQRIENEQGRVRLRRWGERTLDLDILLYGNEIIQNERLTIPHYDMHN
REFVIVPLFEIASDLVLPNSQIITELVKQFADHKMIKLNP
Number of residues
160
Molecular Weight
18298.875
Theoretical pI
6.0
GO Classification
Functions
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity / ATP binding / kinase activity
Processes
folic acid biosynthetic process / tetrahydrofolate biosynthetic process
General Function
Kinase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011052|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
ATGATTACGGCATATATTGCTCTAGGTAGCAATTTAAACACACCAGTAGAACAATTACAT
GCTGCGCTTAAAGCGATAAGTCAGTTATCAAACACTCATTTGGTAACAACGAGCTCTTTT
TATAAAAGCAAACCGCTCGGCCCACAAGATCAACCCGATTATGTGAATGCCGTTGCAAAA
ATTGAAACCGAACTTAGTCCGCTCAAGCTATTAGATGAATTACAGCGTATTGAAAACGAG
CAAGGTCGAGTGCGTTTACGTCGCTGGGGCGAACGCACGTTAGATTTAGATATTTTGCTC
TACGGCAATGAAATTATTCAAAACGAACGCTTAACAATTCCCCATTATGATATGCATAAC
CGTGAGTTTGTCATTGTGCCGTTGTTTGAAATCGCATCGGATTTAGTTTTACCAAATAGT
CAAATCATAACAGAGCTGGTCAAGCAATTTGCTGACCACAAAATGATAAAATTAAATCCC
TAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP43777
UniProtKB Entry NameHPPK_HAEIN
GenBank Protein ID1573012
GenBank Gene IDL42023
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
  2. Hennig M, Dale GE, D'arcy A, Danel F, Fischer S, Gray CP, Jolidon S, Muller F, Page MG, Pattison P, Oefner C: The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae. J Mol Biol. 1999 Mar 26;287(2):211-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB022787,8-dihydro-7,7-dimethyl-6-hydroxypterinexperimentalunknownDetails