Poly(A) polymerase alpha
Details
- Name
- Poly(A) polymerase alpha
- Synonyms
- 2.7.7.19
- PAP
- PAP-alpha
- Polynucleotide adenylyltransferase alpha
- Gene Name
- PAPOLA
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009436|Poly(A) polymerase alpha MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD LSDIPALPANPIPVIKNSIKLRLNR
- Number of residues
- 745
- Molecular Weight
- 82841.78
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / magnesium ion binding / manganese ion binding / polynucleotide adenylyltransferase activity / RNA bindingProcessesgene expression / mRNA 3'-end processing / mRNA polyadenylation / mRNA splicing, via spliceosome / regulation of mRNA 3'-end processing / RNA polyadenylation / RNA splicing / termination of RNA polymerase II transcription / transcription from RNA polymerase II promoterComponentscytoplasm / nucleoplasm / nucleus
- General Function
- Rna binding
- Specific Function
- Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0013158|Poly(A) polymerase alpha (PAPOLA) ATGCCGTTTCCAGTTACAACACAGGGATCACAACAAACACAACCGCCACAGAAGCACTAT GGCATTACTTCTCCTATCAGCTTAGCAGCCCCCAAGGAGACTGACTGCGTACTTACACAG AAACTAATTGAGACATTGAAACCCTTTGGGGTTTTTGAAGAGGAAGAGGAACTGCAGCGC AGGATTTTAATTTTGGGAAAACTAAATAACCTGGTAAAAGAGTGGATACGAGAAATCAGT GAAAGCAAGAATCTTCCACAATCTGTAATTGAAAATGTTGGAGGAAAAATTTTTACATTT GGATCTTACAGATTAGGAGTGCATACAAAAGGTGCTGATATTGATGCGTTGTGTGTTGCA CCAAGACATGTTGATCGAAGTGACTTTTTCACCTCATTCTATGATAAGTTGAAATTACAG GAAGAAGTAAAAGATTTAAGAGCTGTTGAAGAGGCATTCGTACCAGTTATTAAACTCTGT TTTGATGGGATAGAGATTGATATTTTGTTTGCAAGATTAGCACTGCAGACAATTCCTGAA GATTTGGATCTACGAGATGACAGTCTGCTAAAAAATTTAGATATAAGATGTATAAGAAGT CTTAACGGTTGCAGGGTAACCGATGAAATTTTACATCTAGTACCAAACATTGACAACTTC AGGTTAACTCTGAGAGCTATCAAACTATGGGCCAAACGCCACAACATCTATTCCAATATA TTAGGTTTCCTCGGTGGTGTTTCCTGGGCTATGCTAGTAGCAAGAACTTGCCAGCTTTAT CCAAATGCAATAGCATCAACTCTTGTACATAAATTTTTCTTGGTATTTTCTAAATGGTAT GTGTTTAGATTATATTAA
- Chromosome Location
- 14
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P51003 UniProtKB Entry Name PAPOA_HUMAN HGNC ID HGNC:14981 - General References
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