Caspase-7
Details
- Name
- Caspase-7
- Synonyms
- 3.4.22.60
- Apoptotic protease Mch-3
- CASP-7
- CMH-1
- ICE-LAP3
- ICE-like apoptotic protease 3
- MCH3
- Gene Name
- CASP7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0003618|Caspase-7 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY FSQ
- Number of residues
- 303
- Molecular Weight
- 34276.48
- Theoretical pI
- 5.93
- GO Classification
- Functionscysteine-type endopeptidase activity / cysteine-type endopeptidase activity involved in execution phase of apoptosis / cysteine-type peptidase activityProcessesactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / apoptotic process / cellular component disassembly involved in execution phase of apoptosis / execution phase of apoptosis / intrinsic apoptotic signaling pathway / programmed cell death / proteolysisComponentscytoplasm / cytosol / nucleoplasm / nucleus
- General Function
- Cysteine-type peptidase activity
- Specific Function
- Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
- Pfam Domain Function
- Peptidase_C14 (PF00656)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016573|Caspase-7 (CASP7) ATGGCAGATGATCAGGGCTGTATTGAAGAGCAGGGGGTTGAGGATTCAGCAAATGAAGAT TCAGTGGATGCTAAGCCAGACCGGTCCTCGTTTGTACCGTCCCTCTTCAGTAAGAAGAAG AAAAATGTCACCATGCGATCCATCAAGACCACCCGGGACCGAGTGCCTACATATCAGTAC AACATGAATTTTGAAAAGCTGGGCAAATGCATCATAATAAACAACAAGAACTTTGATAAA GTGACAGGTATGGGCGTTCGAAACGGAACAGACAAAGATGCCGAGGCGCTCTTCAAGTGC TTCCGAAGCCTGGGTTTTGACGTGATTGTCTATAATGACTGCTCTTGTGCCAAGATGCAA GATCTGCTTAAAAAAGCTTCTGAAGAGGACCATACAAATGCCGCCTGCTTCGCCTGCATC CTCTTAAGCCATGGAGAAGAAAATGTAATTTATGGGAAAGATGGTGTCACACCAATAAAG GATTTGACAGCCCACTTTAGGGGGGATAGATGCAAAACCCTTTTAGAGAAACCCAAACTC TTCTTCATTCAGGCTTGCCGAGGGACCGAGCTTGATGATGGCATCCAGGCCGACTCGGGG CCCATCAATGACACAGATGCTAATCCTCGATACAAGATCCCAGTGGAAGCTGACTTCCTC TTCGCCTATTCCACGGTTCCAGGCTATTACTCGTGGAGGAGCCCAGGAAGAGGCTCCTGG TTTGTGCAAGCCCTCTGCTCCATCCTGGAGGAGCACGGAAAAGACCTGGAAATCATGCAG ATCCTCACCAGGGTGAATGACAGAGTTGCCAGGCACTTTGAGTCTCAGTCTGATGACCCA CACTTCCATGAGAAGAAGCAGATCCCCTGTGTGGTCTCCATGCTCACCAAGGAACTCTAC TTCAGTCAATAG
- Chromosome Location
- 10
- Locus
- 10q25
- External Identifiers
Resource Link UniProtKB ID P55210 UniProtKB Entry Name CASP7_HUMAN GenBank Protein ID 1125073 GenBank Gene ID U39613 GenAtlas ID CASP7 HGNC ID HGNC:1508 - General References
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