Tyrosine--tRNA ligase
Details
- Name
- Tyrosine--tRNA ligase
- Synonyms
- 6.1.1.1
- Tyrosyl-tRNA synthetase
- TyrRS
- Gene Name
- tyrS
- Organism
- Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
- Amino acid sequence
>lcl|BSEQ0019213|Tyrosine--tRNA ligase MAGTGHTPEEALALLKRGAEEIVPEEELLAKLKEGRPLTVKLGADPTRPDLHLGHAVVLR KMRQFQELGHKVVLIIGDFTGMIGDPSGRSKTRPPLTLEETRENAKTYVAQAGKILRQEP HLFELRYNSEWLEGLTFKEVVRLTSLMTVAQMLEREDFKKRYEAGIPISLHELLYPFAQA YDSVAIRADVEMGGTDQRFNLLVGREVQRAYGQSPQVCFLMPLLVGLDGREKMSKSLDNY IGLTEPPEAMFKKLMRVPDPLLPSYFRLLTDLEEEEIEALLKAGPVPAHRVLARLLTAAY ALPQIPPRIDRAFYESLGYAWEAFGRDKEAGPEEVRRAEARYDEVAKGGIPEEIPEVTIP ASELKEGRIWVARLFTLAGLTPSNAEARRLIQNRGLRLDGEVLTDPMLQVDLSRPRILQR GKDRFVRVRLSD
- Number of residues
- 432
- Molecular Weight
- 48717.765
- Theoretical pI
- 6.44
- GO Classification
- FunctionsATP binding / RNA binding / tyrosine-tRNA ligase activityProcessestyrosyl-tRNA aminoacylationComponentscytoplasm
- General Function
- Tyrosine-trna ligase activity
- Specific Function
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
- Pfam Domain Function
- tRNA-synt_1b (PF00579)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019214|Tyrosine--tRNA ligase (tyrS) ATGGCGGGCACCGGCCACACCCCGGAAGAGGCCCTGGCCCTCCTCAAGCGGGGGGCCGAG GAGATCGTCCCCGAGGAAGAGCTTCTCGCCAAGCTCAAGGAGGGGCGGCCCCTCACGGTC AAGCTCGGGGCCGACCCCACGAGGCCCGACCTGCACCTGGGCCACGCGGTGGTCCTGAGG AAGATGCGCCAGTTCCAAGAGCTCGGCCACAAGGTGGTCCTCATCATCGGCGACTTCACC GGGATGATCGGGGACCCTTCGGGCCGTTCCAAGACCCGGCCCCCCCTCACCCTCGAGGAG ACCCGGGAGAACGCCAAGACCTACGTGGCCCAGGCGGGGAAGATCCTCAGGCAGGAGCCC CACCTCTTTGAGCTCCGCTACAACTCCGAGTGGCTGGAGGGCCTCACCTTCAAGGAGGTG GTGCGCCTCACCTCCCTCATGACCGTGGCCCAGATGCTGGAAAGGGAGGACTTTAAAAAG CGGTACGAGGCGGGGATTCCCATCTCCCTGCACGAGCTTTTGTACCCCTTCGCCCAGGCC TACGACTCCGTGGCCATAAGGGCCGACGTGGAAATGGGGGGCACGGACCAGCGCTTCAAC CTCCTGGTGGGCCGGGAGGTGCAACGGGCCTACGGGCAAAGCCCCCAGGTCTGCTTCCTC ATGCCCCTTCTCGTGGGCCTTGACGGGCGGGAGAAGATGAGCAAGAGCCTGGACAACTAC ATCGGCCTCACCGAGCCCCCGGAGGCGATGTTCAAGAAGCTCATGCGGGTGCCGGACCCT CTCCTCCCGAGCTACTTCCGCCTCCTCACGGACCTGGAGGAGGAGGAAATAGAGGCCCTC CTAAAGGCGGGCCCCGTCCCCGCCCACCGGGTCCTCGCCCGCCTCCTCACCGCGGCCTAC GCCCTGCCCCAGATCCCCCCCCGGATAGACCGGGCCTTTTACGAAAGCCTCGGCTACGCC TGGGAGGCCTTCGGGCGGGACAAGGAGGCGGGCCCCGAGGAGGTAAGGAGGGCGGAAGCC CGCTACGACGAGGTGGCCAAAGGGGGAATCCCCGAGGAGATCCCCGAGGTCACCATCCCC GCCTCGGAGCTGAAGGAAGGCCGGATCTGGGTGGCGAGGCTTTTTACCTTAGCGGGCCTC ACCCCCTCCAACGCCGAGGCGAGGAGGCTCATCCAGAACCGGGGCCTGAGGCTGGACGGG GAGGTCCTCACCGACCCCATGCTCCAGGTGGACCTCTCCCGGCCCCGCATCCTGCAGCGG GGCAAGGACCGCTTCGTGCGGGTGCGGCTTTCGGACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P83453 UniProtKB Entry Name SYY_THET2 GenBank Protein ID 46196960 GenBank Gene ID AE017221 - General References
- Henne A, Bruggemann H, Raasch C, Wiezer A, Hartsch T, Liesegang H, Johann A, Lienard T, Gohl O, Martinez-Arias R, Jacobi C, Starkuviene V, Schlenczeck S, Dencker S, Huber R, Klenk HP, Kramer W, Merkl R, Gottschalk G, Fritz HJ: The genome sequence of the extreme thermophile Thermus thermophilus. Nat Biotechnol. 2004 May;22(5):547-53. Epub 2004 Apr 4. [Article]
- Yaremchuk A, Kriklivyi I, Tukalo M, Cusack S: Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition. EMBO J. 2002 Jul 15;21(14):3829-40. [Article]