Tyrosine-protein kinase receptor TYRO3
Details
- Name
- Tyrosine-protein kinase receptor TYRO3
- Synonyms
- 2.7.10.1
- BYK
- DTK
- RSE
- SKY
- TIF
- Tyrosine-protein kinase BYK
- Tyrosine-protein kinase DTK
- Tyrosine-protein kinase RSE
- Tyrosine-protein kinase SKY
- Tyrosine-protein kinase TIF
- Gene Name
- TYRO3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051686|Tyrosine-protein kinase receptor TYRO3 MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
- Number of residues
- 890
- Molecular Weight
- 96904.425
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / phosphatidylinositol 3-kinase binding / protein heterodimerization activity / protein tyrosine kinase activity / signal transducer, downstream of receptor, with protein tyrosine kinase activity / transmembrane receptor protein tyrosine kinase activity / virus receptor activityProcessesapoptotic cell clearance / cell adhesion / forebrain cell migration / natural killer cell differentiation / negative regulation of inflammatory response / negative regulation of innate immune response / negative regulation of lymphocyte activation / negative regulation of neuron apoptotic process / negative regulation of toll-like receptor signaling pathway / neuron cellular homeostasis / neuropeptide signaling pathway / ovulation cycle / phosphatidylinositol 3-kinase signaling / platelet activation / platelet aggregation / protein autophosphorylation / protein kinase B signaling / secretion by cell / signal transduction / spermatogenesis / substrate adhesion-dependent cell spreading / vagina developmentComponentsendoplasmic reticulum membrane / integral component of plasma membrane / nuclear envelope / nucleus
- General Function
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- 430-450
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0051687|Tyrosine-protein kinase receptor TYRO3 (TYRO3) ATGGCGCTGAGGCGGAGCATGGGGCGGCCGGGGCTCCCGCCGCTGCCGCTGCCGCCGCCA CCGCGGCTCGGGCTGCTGCTGGCGGCTCTGGCTTCTCTGCTGCTCCCGGAGTCCGCCGCC GCAGGTCTGAAGCTCATGGGAGCCCCGGTGAAGCTGACAGTGTCTCAGGGGCAGCCGGTG AAGCTCAACTGCAGTGTGGAGGGGATGGAGGAGCCTGACATCCAGTGGGTGAAGGATGGG GCTGTGGTCCAGAACTTGGACCAGTTGTACATCCCAGTCAGCGAGCAGCACTGGATCGGC TTCCTCAGCCTGAAGTCAGTGGAGCGCTCTGACGCCGGCCGGTACTGGTGCCAGGTGGAG GATGGGGGTGAAACCGAGATCTCCCAGCCAGTGTGGCTCACGGTAGAAGGTGTGCCATTT TTCACAGTGGAGCCAAAAGATCTGGCAGTGCCACCCAATGCCCCTTTCCAACTGTCTTGT GAGGCTGTGGGTCCCCCTGAACCTGTTACCATTGTCTGGTGGAGAGGAACTACGAAGATC GGGGGACCCGCTCCCTCTCCATCTGTTTTAAATGTAACAGGGGTGACCCAGAGCACCATG TTTTCCTGTGAAGCTCACAACCTAAAAGGCCTGGCCTCTTCTCGCACAGCCACTGTTCAC CTTCAAGCACTGCCTGCAGCCCCCTTCAACATCACCGTGACAAAGCTTTCCAGCAGCAAC GCTAGTGTGGCCTGGATGCCAGGTGCTGATGGCCGAGCTCTGCTACAGTCCTGTACAGTT CAGGTGACACAGGCCCCAGGAGGCTGGGAAGTCCTGGCTGTTGTGGTCCCTGTGCCCCCC TTTACCTGCCTGCTCCGGGACCTGGTGCCTGCCACCAACTACAGCCTCAGGGTGCGCTGT GCCAATGCCTTGGGGCCCTCTCCCTATGCTGACTGGGTGCCCTTTCAGACCAAGGGTCTA GCCCCAGCCAGCGCTCCCCAAAACCTCCATGCCATCCGCACAGATTCAGGCCTCATCTTG GAGTGGGAAGAAGTGATCCCCGAGGCCCCTTTGGAAGGCCCCCTGGGACCCTACAAACTG TCCTGGGTTCAAGACAATGGAACCCAGGATGAGCTGACAGTGGAGGGGACCAGGGCCAAT TTGACAGGCTGGGATCCCCAAAAGGACCTGATCGTACGTGTGTGCGTCTCCAATGCAGTT GGCTGTGGACCCTGGAGTCAGCCACTGGTGGTCTCTTCTCATGACCGTGCAGGCCAGCAG GGCCCTCCTCACAGCCGCACATCCTGGGTACCTGTGGTCCTTGGTGTGCTAACGGCCCTG GTGACGGCTGCTGCCCTGGCCCTCATCCTGCTTCGAAAGAGACGGAAAGAGACGCGGTTT GGGCAAGCCTTTGACAGTGTCATGGCCCGGGGAGAGCCAGCCGTTCACTTCCGGGCAGCC CGGTCCTTCAATCGAGAAAGGCCCGAGCGCATCGAGGCCACATTGGACAGCTTGGGCATC AGCGATGAACTAAAGGAAAAACTGGAGGATGTGCTCATCCCAGAGCAGCAGTTCACCCTG GGCCGGATGTTGGGCAAAGGAGAGTTTGGTTCAGTGCGGGAGGCCCAGCTGAAGCAAGAG GATGGCTCCTTTGTGAAAGTGGCTGTGAAGATGCTGAAAGCTGACATCATTGCCTCAAGC GACATTGAAGAGTTCCTCAGGGAAGCAGCTTGCATGAAGGAGTTTGACCATCCACACGTG GCCAAACTTGTTGGGGTAAGCCTCCGGAGCAGGGCTAAAGGCCGTCTCCCCATCCCCATG GTCATCTTGCCCTTCATGAAGCATGGGGACCTGCATGCCTTCCTGCTCGCCTCCCGGATT GGGGAGAACCCCTTTAACCTACCCCTCCAGACCCTGATCCGGTTCATGGTGGACATTGCC TGCGGCATGGAGTACCTGAGCTCTCGGAACTTCATCCACCGAGACCTGGCTGCTCGGAAT TGCATGCTGGCAGAGGACATGACAGTGTGTGTGGCTGACTTCGGACTCTCCCGGAAGATC TACAGTGGGGACTACTATCGTCAAGGCTGTGCCTCCAAACTGCCTGTCAAGTGGCTGGCC CTGGAGAGCCTGGCCGACAACCTGTATACTGTGCAGAGTGACGTGTGGGCGTTCGGGGTG ACCATGTGGGAGATCATGACACGTGGGCAGACGCCATATGCTGGCATCGAAAACGCTGAG ATTTACAACTACCTCATTGGCGGGAACCGCCTGAAACAGCCTCCGGAGTGTATGGAGGAC GTGTATGATCTCATGTACCAGTGCTGGAGTGCTGACCCCAAGCAGCGCCCGAGCTTTACT TGTCTGCGAATGGAACTGGAGAACATCTTGGGCCAGCTGTCTGTGCTATCTGCCAGCCAG GACCCCTTATACATCAACATCGAGAGAGCTGAGGAGCCCACTGCGGGAGGCAGCCTGGAG CTACCTGGCAGGGATCAGCCCTACAGTGGGGCTGGGGATGGCAGTGGCATGGGGGCAGTG GGTGGCACTCCCAGTGACTGTCGGTACATACTCACCCCCGGAGGGCTGGCTGAGCAGCCA GGGCAGGCAGAGCACCAGCCAGAGAGTCCCCTCAATGAGACACAGAGGCTTTTGCTGCTG CAGCAAGGGCTACTGCCACACAGTAGCTGTTAG
- Chromosome Location
- 15
- Locus
- 15q15.1
- External Identifiers
Resource Link UniProtKB ID Q06418 UniProtKB Entry Name TYRO3_HUMAN HGNC ID HGNC:12446 - General References
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