Penicillin-binding protein 1A
Details
- Name
- Penicillin-binding protein 1A
- Synonyms
- PBP-1a
- ponA
- Gene Name
- mrcA
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0017184|Penicillin-binding protein 1A MRLLKFLWWTCVTLICGVLLSFSGAYLYLSPSLPSVEALRNVQLQIPLKVYSEDGKLISE FGEMRRTPIRFADIPQDFIHALLSAEDDNFANHYGVDVKSLMRAAAQLLKSGHIQTGGST ITMQVAKNYFLTNERSFSRKINEILLALQIERQLTKDEILELYVNKIYLGNRAYGIEAAA QVYYGKPIKDLSLAEMAMIAGLPKAPSRYNPLVNPTRSTERRNWILERMLKLGFIDQQRY QAAVEEPINASYHVQTPELNAPYIAEMARAEMVGRYGSEAYTEGYKVITTVRSDLQNAAS QSVRDGLIDYDQRHGYRGPETRLPGQTRDAWLKHLGQQRSIGGLEPAIVTQVEKSGIMVM TRDGKEEAVTWDSMKWARPFLSNNSMGPMPRQPADVAQAGDQIRVQRQEDGTLRFVQIPA AQSALISLDPKDGAIRSLVGGFSFEQSNYNRAIQAKRQPGSSFKPFIYSAALDNGFTAAS LVNDAPIVFVDEYLDKVWRPKNDTNTFLGPIPLREALYKSRNMVSIRVLQGLGIERAISY ITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQVLY QANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAERII DARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKDGWFSGYNSDYVTSVWV GFDQPETLGRREYGGTVALPIWIRYMGFALKDKPMHTMAEPPGIVSLRIDPVTGRSAAPG TPGAYFEMFKNEDTPPSVNELPPGSFPGSPLPDDEGAPIDLF
- Number of residues
- 822
- Molecular Weight
- 91198.715
- Theoretical pI
- 6.01
- GO Classification
- Functionshydrolase activity / penicillin binding / transferase activity, transferring glycosyl groupsProcessescell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- Transferase activity, transferring glycosyl groups
- Specific Function
- Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 6-26
- Cellular Location
- Cell inner membrane
- Gene sequence
>lcl|BSEQ0017185|Penicillin-binding protein 1A (mrcA) ATGCGCCTGCTGAAGTTCCTGTGGTGGACTTGCGTCACCCTGATTTGTGGAGTGCTGCTC AGTTTCAGCGGCGCCTATCTCTATCTGAGTCCCAGCCTGCCCTCGGTGGAAGCTCTGCGT AACGTCCAGCTGCAGATCCCCCTCAAGGTCTACAGCGAGGACGGCAAGCTGATCTCCGAG TTCGGCGAGATGCGCCGGACGCCGATCCGCTTCGCCGACATCCCGCAGGACTTCATCCAT GCCCTGCTGTCCGCCGAGGACGACAATTTCGCCAACCATTATGGCGTCGATGTGAAAAGC CTAATGCGCGCCGCCGCGCAATTATTGAAAAGCGGTCACATCCAGACTGGCGGCAGCACC ATCACCATGCAGGTAGCGAAGAACTACTTCCTTACCAATGAAAGAAGCTTCTCGCGAAAG ATCAATGAAATCCTCCTGGCCCTGCAGATCGAGCGACAGCTGACCAAGGACGAGATCCTC GAGCTCTACGTCAACAAGATCTACCTGGGCAACCGTGCCTATGGCATCGAGGCTGCCGCA CAGGTCTATTACGGCAAGCCGATCAAAGACTTGAGCCTGGCCGAGATGGCGATGATCGCC GGCCTGCCGAAAGCGCCCTCGCGCTACAACCCGCTGGTCAACCCGACCCGCAGTACGGAG CGGCGCAACTGGATCCTCGAGCGCATGCTCAAGCTCGGCTTCATCGACCAGCAACGCTAC CAGGCCGCCGTCGAGGAGCCGATCAACGCCTCCTACCACGTGCAGACCCCCGAACTGAAT GCGCCCTACATCGCCGAGATGGCCCGTGCCGAGATGGTCGGCCGCTACGGCAGCGAGGCC TATACCGAGGGCTACAAGGTCATCACCACGGTCCGCAGCGACCTGCAGAACGCCGCCAGC CAATCGGTCCGCGACGGCCTCATCGACTATGACCAGCGCCACGGCTACCGCGGCCCGGAG ACCCGCCTGCCGGGCCAGACCCGCGACGCCTGGCTCAAGCACCTGGGCCAGCAGCGCAGC ATCGGCGGCCTGGAGCCGGCGATCGTCACCCAGGTGGAAAAGAGCGGGATCATGGTGATG ACCCGCGACGGCAAGGAAGAAGCCGTGACCTGGGACAGCATGAAATGGGCACGCCCCTTC CTCAGCAACAACAGCATGGGCCCGATGCCGCGCCAGCCCGCCGACGTGGCCCAGGCCGGC GACCAGATCCGCGTGCAGCGCCAGGAAGACGGCACCCTGCGCTTCGTACAGATTCCCGCC GCACAGAGCGCGCTGATCTCCCTTGACCCGAAGGACGGGGCGATCCGCTCGCTGGTCGGC GGCTTCTCCTTCGAGCAGAGCAACTACAACCGCGCGATCCAGGCCAAGCGCCAGCCGGGC TCCAGTTTCAAGCCGTTCATCTACAGCGCGGCCCTGGACAACGGCTTCACCGCCGCCAGC CTGGTCAACGATGCGCCGATCGTGTTCGTCGACGAGTACCTGGACAAGGTCTGGCGACCG AAGAACGACACCAATACCTTCCTCGGCCCGATCCCGCTGCGCGAAGCCCTGTACAAGTCC CGCAACATGGTCTCGATCCGCGTCCTGCAGGGCCTGGGCATCGAGCGGGCGATCAGCTAC ATCACCAAGTTCGGCTTCCAGCGCGACGAACTGCCGCGCAACTTCTCCCTGGCCCTGGGT ACCGCGACAGTCACACCGATGGAAATCGCCGGCGCCTGGAGCGTATTCGCCAACGGCGGC TACAAGGTCAATCCGTACGTCATCGAACGCATCGAGAGCCGCGACGGACAGGTGCTGTAC CAGGCCAATCCGCCCCGCGTGCCGGTGGAAGAACAGGTCGCTGCGGATGCGGAAGACGCC GGGAATCCTGGTGACCCCGAGCATCCGGAGAGCGCCGAAGGCGAAGGTTCGATCGAAGCC CAGCAAGTCGCCGCCAAGGCCCAGACCACCTTCGAGCCGACCCCGGCCGAGCGGATCATC GATGCCCGTACCGCCTATATCATGACCAGCATGCTGCAGGACGTGATCAAGCGCGGTACC GGGCGTCGCGCCCTGGCGCTGAAGCGCACCGACCTGGCCGGCAAGACCGGCACCACCAAC GATTCCAAGGATGGCTGGTTCTCCGGCTACAACTCCGACTACGTGACCAGCGTCTGGGTC GGCTTCGACCAGCCGGAGACCCTGGGTCGCCGCGAGTACGGCGGTACCGTCGCGCTGCCG ATCTGGATCAGGTACATGGGCTTCGCCCTCAAGGACAAGCCGATGCACACCATGGCCGAG CCGCCAGGCATCGTCAGCCTGCGCATCGACCCGGTGACCGGCCGTTCGGCCGCGCCGGGC ACTCCCGGCGCCTATTTCGAGATGTTCAAGAACGAGGATACCCCGCCCTCGGTCAATGAA CTGCCGCCAGGCAGCTTCCCTGGCAGCCCGCTGCCGGATGACGAAGGCGCGCCGATCGAC CTGTTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q07806 UniProtKB Entry Name PBPA_PSEAE GenBank Protein ID 1763284 GenBank Gene ID U73780 - General References
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Martin PR, Hobbs M, Free PD, Jeske Y, Mattick JS: Characterization of pilQ, a new gene required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa. Mol Microbiol. 1993 Aug;9(4):857-68. [Article]