Nuclear factor erythroid 2-related factor 1
Details
- Name
- Nuclear factor erythroid 2-related factor 1
- Synonyms
- HBZ17
- Locus control region-factor 1
- NF-E2-related factor 1
- NRF1
- Nuclear factor, erythroid derived 2, like 1
- TCF-11
- TCF11
- Transcription factor 11
- Transcription factor HBZ17
- Transcription factor LCR-F1
- Gene Name
- NFE2L1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007928|Nuclear factor erythroid 2-related factor 1 MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRN TLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPNS GLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDIDLIDILWR QDIDLGAGREVFDYSHRQKEQDVEKELRDGGEQDTWAGEGAEALARNLLVDGETGESFPA QVPSGEDQTALSLEECLRLLEATCPFGENAEFPADISSITEAVPSESEPPALQNNLLSPL LTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLSTNYSLAPNTPINQN VSLHQASLGGCSQDFLLFSPEVESLPVASSSTLLPLAPSNSTSLNSTFGSTNLTGLFFPP QLNGTANDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLS LDSSHSPSSLSSSEGSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEG AVGYQPEYSKFCRMSYQDPAQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSALKKGSK EKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRR RGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQE VFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK
- Number of residues
- 772
- Molecular Weight
- 84702.845
- Theoretical pI
- 4.25
- GO Classification
- FunctionsRNA polymerase II distal enhancer sequence-specific DNA binding / transcription cofactor activity / transcription factor activity, sequence-specific DNA binding / transcription regulatory region sequence-specific DNA binding / transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding / transcriptional activator activity, RNA polymerase II transcription factor bindingProcessesanatomical structure morphogenesis / cellular response to oxidative stress / erythrocyte differentiation / heme biosynthetic process / inflammatory response / positive regulation of transcription, DNA-templated / regulation of transcription from RNA polymerase II promoter / transcription from RNA polymerase II promoterComponentscytoplasm / endoplasmic reticulum membrane / integral component of membrane / nucleus
- General Function
- Transcriptional activator activity, rna polymerase ii transcription factor binding
- Specific Function
- Activates erythroid-specific, globin gene expression.
- Pfam Domain Function
- bZIP_Maf (PF03131)
- Transmembrane Regions
- 7-24
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0019532|Nuclear factor erythroid 2-related factor 1 (NFE2L1) ATGCTTTCTCTGAAGAAATACTTAACGGAAGGACTTCTCCAGTTCACCATTCTGCTGAGT TTGATTGGGGTACGGGTGGACGTGGATACTTACCTGACCTCACAGCTTCCCCCACTCCGG GAGATCATCCTGGGGCCCAGTTCTGCCTATACTCAGACCCAGTTCCACAACCTGAGGAAT ACCTTGGATGGCTATGGTATCCACCCCAAGAGCATAGACCTGGACAATTACTTCACTGCC CGGCGGCTCCTCAGTCAGGTGAGGGCCCTGGACAGGTTCCAGGTGCCAACCACTGAGGTA AATGCCTGGCTGGTTCACCGAGACCCAGAGGGGTCTGTCTCTGGCAGTCAGCCCAACTCA GGCCTCGCCCTCGAGAGTTCCAGTGGCCTCCAAGATGTGACAGGCCCAGACAACGGGGTG CGAGAAAGCGAAACGGAGCAGGGATTCGGTGAAGATTTGGAGGATTTGGGGGCTGTAGCC CCCCCAGTCAGTGGAGACTTAACCAAAGAGGACATAGATCTGATTGACATCCTTTGGCGA CAGGATATTGATCTGGGGGCTGGGCGTGAGGTTTTTGACTATAGTCACCGCCAGAAGGAG CAGGATGTGGAGAAGGAGCTGCGAGATGGAGGCGAGCAGGACACCTGGGCAGGCGAGGGC GCGGAAGCTCTGGCACGGAACCTGCTAGTGGATGGAGAGACTGGGGAGAGCTTCCCTGCA CAGGTGCCTAGTGGGGAGGACCAGACGGCCCTGTCCCTGGAAGAGTGCCTTAGGCTGCTG GAAGCCACCTGCCCCTTTGGGGAGAATGCTGAGTTTCCAGCAGACATTTCCAGCATAACA GAAGCAGTGCCTAGTGAGAGTGAGCCCCCTGCTCTTCAAAACAACCTCTTGTCTCCTCTT CTGACCGGGACAGAGTCACCATTTGATTTGGAACAGCAGTGGCAAGATCTCATGTCCATC ATGGAAATGCAGGCCATGGAAGTGAACACATCAGCAAGTGAAATCCTGTACAGTGCCCCT CCTGGAGACCCACTGAGCACCAACTACAGCCTTGCCCCCAACACTCCCATCAATCAGAAT GTCAGCCTGCATCAGGCGTCCCTGGGGGGCTGCAGCCAGGACTTCTTACTCTTCAGCCCC GAGGTGGAAAGCCTGCCTGTGGCCAGTAGCTCCACGCTGCTCCCGTTGGCCCCCAGCAAT TCTACCAGCCTCAACTCCACCTTCGGCTCCACCAACCTGACAGGGCTCTTCTTTCCACCC CAGCTCAATGGCACAGCCAATGACACAGCAGGCCCAGAGCTGCCTGACCCTTTGGGGGGT CTGTTAGATGAAGCTATGTTGGATGAGATCAGCCTTATGGACCTGGCCATTGAAGAAGGC TTTAACCCTGTGCAGGCCTCCCAGCTGGAGGAGGAATTTGACTCTGACTCAGGCCTTTCC TTAGACTCGAGCCATAGCCCTTCTTCCCTAAGCAGCTCTGAAGGCAGTTCTTCCTCTTCT TCCTCCTCCTCTTCCTCTTCTTCCTCTGCTTCTTCCTCTGCCTCTTCCTCCTTTTCTGAG GAAGGTGCGGTTGGCTACAGCTCTGACTCTGAGACCCTGGATCTGGAAGAGGCCGAGGGT GCTGTGGGCTACCAGCCTGAGTATTCCAAGTTCTGCCGCATGAGCTACCAGGATCCAGCT CAGCTCTCATGCCTGCCCTACCTGGAGCACGTGGGCCACAACCACACATACAACATGGCA CCCAGTGCCCTGGACTCAGCCGACCTGCCACCACCCAGTGCCCTCAAGAAAGGCAGCAAG GAGAAGCAGGCTGACTTCCTGGACAAGCAGATGAGCCGGGATGAGCACCGAGCCCGAGCC ATGAAGATCCCTTTCACCAATGACAAAATCATCAACCTGCCTGTGGAGGAGTTCAATGAA CTGCTGTCCAAATACCAGTTGAGTGAAGCCCAGCTGAGCCTCATCCGAGACATCCGGCGC CGGGGCAAGAACAAGATGGCGGCGCAGAACTGCCGCAAGCGCAAGCTGGACACCATCCTG AATCTGGAGCGTGATGTGGAGGACCTGCAGCGTGACAAAGCCCGGCTGCTGCGGGAGAAA GTGGAGTTCCTGCGCTCCCTGCGACAGATGAAGCAGAAGGTCCAGAGCCTGTACCAGGAG GTGTTTGGGCGGCTGCGAGATGAGAACGGACGACCCTACTCGCCCAGTCAGTATGCGCTC CAGTACGCCGGGGACGGCAGTGTCCTCCTCATCCCCCGCACGATGGCCGACCAGCAGGCC CGGCGGCAGGAGAGGAAGCCAAAGGACCGGAGAAAGTGA
- Chromosome Location
- 17
- Locus
- 17q21.3
- External Identifiers
Resource Link UniProtKB ID Q14494 UniProtKB Entry Name NF2L1_HUMAN GenBank Gene ID L24123 HGNC ID HGNC:7781 - General References
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- Caterina JJ, Donze D, Sun CW, Ciavatta DJ, Townes TM: Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. Nucleic Acids Res. 1994 Jun 25;22(12):2383-91. [Article]
- Wang W, Chan JY: Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem. 2006 Jul 14;281(28):19676-87. Epub 2006 May 10. [Article]