Neuropeptide Y receptor type 5
Details
- Name
- Neuropeptide Y receptor type 5
- Synonyms
- NPY-Y5 receptor
- NPY5-R
- NPYR5
- NPYY5-R
- Y5 receptor
- Gene Name
- NPY5R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037208|Neuropeptide Y receptor type 5 MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL NPILYGFLNNGIKADLVSLIHCLHM
- Number of residues
- 445
- Molecular Weight
- 50725.99
- Theoretical pI
- 8.84
- GO Classification
- Functionsneuropeptide Y receptor activity / pancreatic polypeptide receptor activity / peptide YY receptor activityProcessescardiac left ventricle morphogenesis / cell surface receptor signaling pathway / eating behavior / feeding behavior / G-protein coupled receptor signaling pathway / generation of ovulation cycle rhythm / negative regulation of apoptotic process / negative regulation of glutamate secretion / negative regulation of synaptic transmission, GABAergic / neuropeptide signaling pathway / outflow tract morphogenesis / positive regulation of acute inflammatory response / positive regulation of smooth muscle cell proliferation / synaptic transmissionComponentscytoplasm / integral component of plasma membrane / neuron projection / plasma membrane
- General Function
- Peptide yy receptor activity
- Specific Function
- Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 43-63 78-98 118-138 157-177 209-229 370-390 408-428
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011756|Neuropeptide Y receptor type 5 (NPY5R) ATGGATTTAGAGCTCGACGAGTATTATAACAAGACACTTGCCACAGAGAATAATACTGCT GCCACTCGGAATTCTGATTTCCCAGTCTGGGATGACTATAAAAGCAGTGTAGATGACTTA CAGTATTTTCTGATTGGGCTCTATACATTTGTAAGTCTTCTTGGCTTTATGGGGAATCTA CTTATTTTAATGGCTCTCATGAAAAAGCGTAATCAGAAGACTACGGTAAACTTCCTCATA GGCAATCTGGCCTTTTCTGATATCTTGGTTGTGCTGTTTTGCTCACCTTTCACACTGACG TCTGTCTTGCTGGATCAGTGGATGTTTGGCAAAGTCATGTGCCATATTATGCCTTTTCTT CAATGTGTGTCAGTTTTGGTTTCAACTTTAATTTTAATATCAATTGCCATTGTCAGGTAT CATATGATAAAACATCCCATATCTAATAATTTAACAGCAAACCATGGCTACTTTCTGATA GCTACTGTCTGGACACTAGGTTTTGCCATCTGTTCTCCCCTTCCAGTGTTTCACAGTCTT GTGGAACTTCAAGAAACATTTGGTTCAGCATTGCTGAGCAGCAGGTATTTATGTGTTGAG TCATGGCCATCTGATTCATACAGAATTGCCTTTACTATCTCTTTATTGCTAGTTCAGTAT ATTCTGCCCTTAGTTTGTCTTACTGTAAGTCATACAAGTGTCTGCAGAAGTATAAGCTGT GGATTGTCCAACAAAGAAAACAGACTTGAAGAAAATGAGATGATCAACTTAACTCTTCAT CCATCCAAAAAGAGTGGGCCTCAGGTGAAACTCTCTGGCAGCCATAAATGGAGTTATTCA TTCATCAAAAAACACAGAAGAAGATATAGCAAGAAGACAGCATGTGTGTTACCTGCTCCA GAAAGACCTTCTCAAGAGAACCACTCCAGAATACTTCCAGAAAACTTTGGCTCTGTAAGA AGTCAGCTCTCTTCATCCAGTAAGTTCATACCAGGGGTCCCCACTTGCTTTGAGATAAAA CCTGAAGAAAATTCAGATGTTCATGAATTGAGAGTAAAACGTTCTGTTACAAGAATAAAA AAGAGATCTCGAAGTGTTTTCTACAGACTGACCATACTGATATTAGTATTTGCTGTTAGT TGGATGCCACTACACCTTTTCCATGTGGTAACTGATTTTAATGACAATCTTATTTCAAAT AGGCATTTCAAGTTGGTGTATTGCATTTGTCATTTGTTGGGCATGATGTCCTGTTGTCTT AATCCAATTCTATATGGGTTTCTTAATAATGGGATTAAAGCTGATTTAGTGTCCCTTATA CACTGTCTTCATATGTAA
- Chromosome Location
- 4
- Locus
- 4q31-q32
- External Identifiers
Resource Link UniProtKB ID Q15761 UniProtKB Entry Name NPY5R_HUMAN GenBank Gene ID U56079 GenAtlas ID NPY5R HGNC ID HGNC:7958 - General References
- Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML: Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem. 1996 Oct 18;271(42):26315-9. [Article]
- Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL: A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 1996 Jul 11;382(6587):168-71. [Article]
- Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J: Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics. 1997 May 1;41(3):315-9. [Article]
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