GDP-mannose 4,6-dehydratase
Details
- Name
- GDP-mannose 4,6-dehydratase
- Synonyms
- 4.2.1.47
- gca
- GDP-D-mannose dehydratase
- Gene Name
- gmd
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0012290|GDP-mannose 4,6-dehydratase MTRSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGDIQYEDGDM ADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAIRQFSPETR FYQASTSEMFGLIQAERQDENTPFYPRSPYGVAKLYGHWITVNYRESFGLHASSGILFNH ESPLRGIEFVTRKVTDAVARIKLGKQQELRLGNVDAKRDWGFAGDYVEAMWLMLQQDKAD DYVVATGVTTTVRDMCQIAFEHVGLDYRDFLKIDPAFFRPAEVDVLLGNPAKAQRVLGWK PRTSLDELIRMMVEADLRRVSRE
- Number of residues
- 323
- Molecular Weight
- 36399.08
- Theoretical pI
- 6.53
- GO Classification
- FunctionsGDP-mannose 4,6-dehydratase activity / NADP+ bindingProcessesGDP-mannose metabolic process / lipopolysaccharide biosynthetic process
- General Function
- Nadp+ binding
- Specific Function
- Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
- Pfam Domain Function
- GDP_Man_Dehyd (PF16363)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012291|GDP-mannose 4,6-dehydratase (gmd) ATGACAAGAAGTGCACTGGTAACTGGGATCACCGGTCAGGACGGAGCGTACCTGGCCAAG CTGCTGCTGGAGAAGGGCTACCGGGTCCACGGCCTGGTGGCGCGGCGCAGCAGCGACACG CGCTGGCGCCTGCGCGAACTGGGGATCGAAGGCGATATCCAGTACGAGGACGGCGACATG GCCGATGCCTGTTCGGTGCAGCGCGCGGTGATCAAGGCGCAGCCGCAGGAGGTCTACAAC CTGGCGGCACAGAGCTTCGTCGGGGCCTCCTGGAACCAGCCGGTGACCACCGGCGTCGTC GACGGCCTGGGCGTGACCCACCTGCTCGAGGCGATCCGCCAGTTCAGCCCGGAAACGCGC TTCTACCAGGCTTCCACCAGCGAGATGTTCGGCCTGATCCAGGCCGAGCGCCAGGACGAG AACACGCCGTTCTACCCGCGCAGCCCCTACGGCGTGGCCAAGCTCTATGGCCACTGGATC ACCGTCAACTATCGCGAGAGCTTCGGCCTGCACGCCTCCAGCGGCATCCTGTTCAACCAC GAATCGCCGCTGCGCGGCATCGAGTTCGTCACGCGCAAGGTTACCGACGCGGTGGCCCGC ATCAAGCTCGGCAAGCAGCAGGAATTGCGCCTGGGCAACGTCGACGCCAAGCGCGACTGG GGCTTTGCCGGGGACTACGTCGAAGCCATGTGGCTGATGTTGCAGCAGGACAAGGCCGAC GACTACGTGGTGGCCACCGGTGTCACTACCACCGTGCGCGACATGTGCCAGATCGCTTTC GAGCATGTGGGCCTGGACTACCGCGACTTCCTCAAGATCGACCCGGCGTTCTTCCGGCCC GCCGAGGTCGACGTGCTGCTGGGTAATCCGGCCAAGGCCCAGCGTGTGCTCGGCTGGAAG CCCAGGACCAGCCTGGACGAGCTGATCCGGATGATGGTCGAGGCGGACCTGCGACGCGTT TCCCGGGAGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q51366 UniProtKB Entry Name GM4D_PSEAE GenBank Gene ID U18320 - General References
- Currie HL, Lightfoot J, Lam JS: Prevalence of gca, a gene involved in synthesis of A-band common antigen polysaccharide in Pseudomonas aeruginosa. Clin Diagn Lab Immunol. 1995 Sep;2(5):554-62. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Webb NA, Mulichak AM, Lam JS, Rocchetta HL, Garavito RM: Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway. Protein Sci. 2004 Feb;13(2):529-39. [Article]