Pantothenate synthetase

Details

Name

Pantothenate synthetase

Synonyms

• 6.3.2.1
• Pantoate--beta-alanine ligase
• Pantoate-activating enzyme
• PS

Gene Name

panC

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Amino acid sequence

>lcl|BSEQ0013192|Pantothenate synthetase
MRTVSTVAELRAALPREGVGFVPTMGYLHRGHLALVERARRENPFVVVSVFVNPLQFGPG
EDYHRYPRDLERDRALLQEAGVDLLFAPGVEEMYPEGFATRVQVEGPLTALWEGAVRPGH
FQGVATVVARLFLLVQPQRAYFGEKDYQQLLVVRRMVRDLGFPVEVVGVPTVREEDGLAL
SSRNVYLSPETRKKAPVLYRALLAMREVAGQGGSVAEALRAGEEALRAVPEFRKDYLAIV
HPETLLPLSDWVAGARGIVAGRFPEARLIDNLEVYP

Number of residues

276

Molecular Weight

30695.125

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / pantoate-beta-alanine ligase activity

Processes

pantothenate biosynthetic process

Components

cytoplasm

General Function

Pantoate-beta-alanine ligase activity

Specific Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Pfam Domain Function

• Pantoate_ligase (PF02569)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0013193|Pantothenate synthetase (panC)
GTGAGAACCGTGAGCACCGTGGCCGAGCTGCGGGCGGCCCTGCCCCGGGAGGGCGTGGGC
TTCGTCCCCACCATGGGCTACCTCCACCGGGGGCACCTCGCCCTGGTGGAACGGGCCCGG
CGGGAGAACCCCTTCGTGGTGGTCTCCGTCTTCGTCAACCCCCTCCAGTTCGGCCCCGGG
GAGGACTACCACCGCTACCCCCGGGACCTGGAGCGGGACCGGGCCCTTTTGCAGGAGGCG
GGGGTGGACCTCCTCTTCGCCCCCGGCGTGGAGGAGATGTACCCCGAGGGCTTCGCCACC
CGGGTCCAGGTGGAGGGTCCCCTCACCGCCCTTTGGGAGGGGGCGGTGCGCCCCGGCCAC
TTCCAGGGGGTGGCCACGGTGGTGGCGCGGCTTTTCCTTTTGGTCCAGCCCCAGAGGGCC
TACTTCGGGGAGAAGGACTACCAGCAGCTCCTCGTGGTGCGGCGGATGGTCCGGGACCTG
GGCTTCCCCGTGGAGGTGGTGGGGGTGCCCACGGTGCGGGAGGAGGACGGCCTCGCCCTT
TCCAGCCGCAACGTCTACCTCTCCCCCGAGACCCGCAAGAAGGCCCCCGTGCTCTACCGG
GCCCTCCTGGCCATGCGGGAGGTGGCGGGGCAGGGGGGAAGCGTGGCCGAGGCGCTCCGG
GCGGGAGAGGAGGCTTTGCGGGCGGTGCCCGAGTTCCGCAAGGACTACCTCGCCATCGTC
CACCCCGAGACCCTCCTGCCCCTCTCCGACTGGGTCGCGGGGGCCAGGGGGATCGTGGCC
GGGAGGTTCCCCGAGGCGCGGCTTATAGACAACCTGGAGGTCTACCCATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q5SHF5
UniProtKB Entry Name	PANC_THET8

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03570	Tris-Hydroxymethyl-Methyl-Ammonium	experimental	unknown		Details