Holliday junction ATP-dependent DNA helicase RuvB
Details
- Name
- Holliday junction ATP-dependent DNA helicase RuvB
- Synonyms
- 3.6.4.12
- Gene Name
- ruvB
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Amino acid sequence
>lcl|BSEQ0011967|Holliday junction ATP-dependent DNA helicase RuvB MEDLALRPKTLDEYIGQERLKQKLRVYLEAAKARKEPLEHLLLFGPPGLGKTTLAHVIAH ELGVNLRVTSGPAIEKPGDLAAILANSLEEGDILFIDEIHRLSRQAEEHLYPAMEDFVMD IVIGQGPAARTIRLELPRFTLIGATTRPGLITAPLLSRFGIVEHLEYYTPEELAQGVMRD ARLLGVRITEEAALEIGRRSRGTMRVAKRLFRRVRDFAQVAGEEVITRERALEALAALGL DELGLEKRDREILEVLILRFGGGPVGLATLATALSEDPGTLEEVHEPYLIRQGLLKRTPR GRVATELAYRHLGYPPPVGPLLEP
- Number of residues
- 324
- Molecular Weight
- 35973.305
- Theoretical pI
- 6.33
- GO Classification
- FunctionsATP binding / DNA binding / four-way junction helicase activityProcessesDNA recombination / DNA repair / SOS response
- General Function
- Four-way junction helicase activity
- Specific Function
- The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvB is a Mg(2+)-dependent, DNA-dependent ATPase with an equal preference for supercoiled and linear duplex DNA. It can promote Holliday junction migration alone.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0011968|Holliday junction ATP-dependent DNA helicase RuvB (ruvB) GTGGAAGACCTCGCCCTTAGGCCCAAGACCCTGGACGAGTACATCGGCCAGGAGCGCCTG AAGCAAAAGCTCCGGGTCTACCTCGAGGCGGCCAAGGCCCGAAAAGAGCCCTTGGAGCAC CTCCTCCTCTTCGGCCCCCCGGGCCTGGGCAAGACCACCCTGGCCCACGTCATCGCCCAC GAGCTTGGGGTCAACCTCCGGGTCACCTCCGGGCCCGCCATAGAGAAGCCCGGGGACCTC GCCGCCATCCTGGCCAACTCCCTGGAGGAAGGGGACATCCTCTTCATTGACGAGATCCAC CGCCTGAGCCGCCAGGCCGAGGAGCACCTCTACCCCGCCATGGAGGACTTCGTCATGGAC ATCGTCATCGGCCAAGGTCCGGCGGCGAGGACCATCCGGCTGGAGCTTCCCCGCTTCACC CTGATCGGGGCCACCACCCGGCCCGGCCTCATCACCGCGCCCCTCCTGAGCCGCTTCGGC ATCGTGGAGCACCTGGAGTACTACACCCCTGAGGAGCTGGCCCAAGGGGTGATGCGGGAC GCCCGCCTCCTCGGGGTGAGGATCACGGAGGAGGCCGCCCTGGAGATCGGTAGGCGGAGC CGGGGCACCATGCGCGTCGCCAAGCGCCTCTTCCGGAGGGTGCGGGACTTCGCCCAGGTG GCGGGGGAGGAGGTCATCACCCGGGAGCGGGCCCTGGAGGCCCTTGCCGCCCTGGGCCTG GACGAGCTGGGCTTGGAGAAGCGGGACCGGGAGATCCTGGAGGTCCTCATCCTCCGCTTC GGCGGCGGCCCCGTGGGCCTCGCCACCCTGGCCACCGCCCTCTCCGAGGACCCGGGCACC TTGGAAGAGGTGCACGAGCCCTACCTCATCCGCCAGGGCCTTTTGAAGCGCACTCCCCGG GGCCGGGTGGCCACGGAACTGGCCTACCGCCACCTGGGCTACCCGCCCCCGGTGGGCCCC CTCTTGGAGCCGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q5SL87 UniProtKB Entry Name RUVB_THET8 GenBank Gene ID AB015236 - General References
- Yamada K, Fukuoh A, Iwasaki H, Shinagawa H: Novel properties of the Thermus thermophilus RuvB protein, which promotes branch migration of Holliday junctions. Mol Gen Genet. 1999 Jul;261(6):1001-11. [Article]
- Yamada K, Kunishima N, Mayanagi K, Ohnishi T, Nishino T, Iwasaki H, Shinagawa H, Morikawa K: Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1442-7. Epub 2001 Feb 6. [Article]