Cyclooxygenase 2
Details
- Name
- Cyclooxygenase 2
- Synonyms
- COX-2
- Prostaglandin G/H synthase-2
- Prostaglandin-endoperoxide synthase 2
- Gene Name
- PTGS2
- Organism
- Canis lupus familiaris
- Amino acid sequence
>lcl|BSEQ0051973|Cyclooxygenase 2 MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFL TRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNY GYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGT NMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKY QVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD VLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ NRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRV AGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEAL YGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEV GFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKER STEL
- Number of residues
- 604
- Molecular Weight
- 68974.625
- Theoretical pI
- Not Available
- GO Classification
- Functionsenzyme binding / heme binding / peroxidase activity / prostaglandin-endoperoxide synthase activity / protein homodimerization activityProcessesbrown fat cell differentiation / cellular response to fluid shear stress / cellular response to hypoxia / cellular response to non-ionic osmotic stress / cyclooxygenase pathway / decidualization / embryo implantation / inflammatory response / negative regulation of apoptotic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress / positive regulation of brown fat cell differentiation / positive regulation of fever generation / positive regulation of peptidyl-serine phosphorylation / positive regulation of prostaglandin biosynthetic process / regulation of blood pressure / regulation of cell proliferation / response to oxidative stressComponentscytoplasm / endoplasmic reticulum / neuron projection
- General Function
- Not Available
- Specific Function
- Enzyme binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051974|Cyclooxygenase 2 (PTGS2) ATGCTGGCCCGCGCCCTGGTGCTCTGCGCCGCCCTGGCGGTCGTCCGCGCAGCAAATCCT TGCTGTTCCCACCCATGTCAAAACCAAGGTATTTGTATGAGCACAGGATTTGACCAGTAT AAGTGTGACTGTACCCGAACAGGATTCTACGGCGAAAACTGCTCAACACCGGAATTTCTG ACAAGAATAAAATTATACCTGAAACCCACTCCAAATACAGTACACTACATACTTACCCAC TTCAAGGGAGTCTGGAACATTGTCAATAACATCCCCTTCCTGCGAAATACAATTATGAAA TATGTGTTGACATCCCGGTCACATTTGATTGAGAGTCCACCAACTTATAATGTGAACTAC GGCTATAAAAGCTGGGAAGCCTTTTCTAACCTCTCCTATTATACCAGAGCTCTTCCCCCT GTACCTGATGACTGTCCAACACCCATGGGTGTGAAAGGCAAGAAAGAGCTTCCTGATTCA AAAGAGATTGTGGAAAAGTTTCTTCTGCGAAGAAAGTTCATTCCTGATCCCCAAGGCACC AATATGATGTTTGCATTCTTTGCCCAGCACTTTACCCATCAATTTTTCAAGACAGATCAT AAGCGAGGACCAGCTTTCACCAAAGGATTGGGCCATGGGGTGGACTTAAATCATGTTTAT GGGGAAACTTTGGATAGACAACATAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT CAGGTAATTGATGGAGAGGTGTATCCTCCTACCGTCAAAGATACTCAGGTCGAGATGATC TACCCACCTCATGTTCCTGAACACCTGCAGTTTGCTGTGGGCCAGGAGGTCTTTGGTCTG GTGCCTGGTCTGATGATGTATGCCACCATTTGGCTGCGGGAGCATAACAGAGTGTGTGAT GTGCTTAAACAGGAGCACCCAGAATGGGATGATGAGCGGTTATTCCAGACGAGCAGGCTA ATACTTATAGGAGAAACCATTAAGATTGTGATTGAAGACTATGTACAACACTTGAGTGGC TATCACTTCAAGCTGAAGTTTGACCCAGAGCTGCTTTTCAACCAACAATTCCAGTACCAA AACCGCATTGCTGCTGAGTTTAACACACTCTACCACTGGCATCCCCTCCTGCCTGACACC TTGCAAATAGATGACCAGGAGTACAATTTCCAACAGTTTATCTACAACAACTCTATATTA TTGGAACATGGCCTTACCCAGTTTGTGGAATCATTCAGCAGGCAAATTGCTGGCAGGGTT GCCGGTGGCAGGAATGTTCCAGCTGCAGTACAACAAGTAGCAAAAGCTTCGATTGACCAG AGCAGACAGATGAAATACCAGTCTCTTAATGAGTATCGCAAACGCTTTAGGCTGAAGCCC TATACATCATTCGAAGAACTTACAGGAGAGAAGGAAATGGCTGCGGGGTTGGAGGCCCTT TATGGTGATATTGATGCCATGGAGCTGTATCCTGCCCTCTTGGTAGAAAAGCCTCGTCCA GATGCCATCTTTGGTGAGACCATGGTAGAAATGGGAGCACCATTCTCCTTGAAAGGACTT ATGGGTAATCCCATCTGTTCACCTGACTACTGGAAGCCTAGCACCTTTGGTGGAGAAGTA GGCTTTAAAATCATCAACACTGCCTCAATCCAGTCTCTCATCTGCAATAACGTGAAGGGC TGTCCATTCACTGCATTCTCTGTTCAAGACGGACAACTCACCAAAACAGTCACCATTAAT GCAAGCTCTTCGCACTCCGGTCTAGATGACATCAATCCCACAGTCCTACTGAAAGAACGG TCAACTGAACTATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8SPQ9 UniProtKB Entry Name Q8SPQ9_CANLF - General References
- Boutemmine D, Bouchard N, Boerboom D, Jones HE, Goff AK, Dore M, Sirois J: Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro. Endocrinology. 2002 Mar;143(3):1134-43. doi: 10.1210/endo.143.3.8695. [Article]
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- Whiteley MH, Bell JS, Rothman DA: Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs. PLoS One. 2011 Feb 8;6(2):e16684. doi: 10.1371/journal.pone.0016684. [Article]