MKL/myocardin-like protein 1
Details
- Name
- MKL/myocardin-like protein 1
- Synonyms
- KIAA1438
- MAL
- Megakaryoblastic leukemia 1 protein
- Megakaryocytic acute leukemia protein
- MRTF-A
- Myocardin-related transcription factor A
- Gene Name
- MKL1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007909|MKL/myocardin-like protein 1 MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLK LKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSS DALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQP PLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQ YIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEAL GSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELK LRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPA LVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMV TSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRM LRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPS LAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLIT DSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSL LKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPK TVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLI DDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVL SLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL
- Number of residues
- 931
- Molecular Weight
- 98917.94
- Theoretical pI
- 5.66
- GO Classification
- Functionsactin binding / actin monomer binding / leucine zipper domain binding / RNA polymerase II transcription coactivator activity / transcription coactivator activity / transcription factor activity, sequence-specific DNA binding / transcription regulatory region sequence-specific DNA bindingProcessesnegative regulation of apoptotic signaling pathway / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription via serum response element binding / small GTPase mediated signal transduction / smooth muscle cell differentiationComponentscytoplasm / cytosol / nucleoplasm / nucleus
- General Function
- Transcription regulatory region sequence-specific dna binding
- Specific Function
- Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0019528|MKL/myocardin-like protein 1 (MKL1) ATGCCGCCTTTGAAAAGTCCAGCCGCATTTCATGAGCAGAGAAGGAGCTTGGAGCGGGCC AGGACAGAGGACTATCTCAAACGGAAGATTCGTTCCCGGCCGGAGAGATCGGAGCTGGTC AGGATGCACATTTTGGAAGAGACCTCGGCTGAGCCATCCCTCCAGGCCAAGCAGCTGAAG CTGAAGAGAGCCAGACTAGCCGATGACCTCAATGAGAAGATTGCACAGAGGCCTGGCCCC ATGGAGCTGGTGGAGAAGAACATCCTTCCTGTTGAGTCCAGCCTGAAGGAAGCCATCATT GTGGGCCAGGTGAACTATCCCAAAGTAGCAGACAGCTCTTCCTTCGATGAGGACAGCAGC GATGCCTTATCCCCCGAGCAGCCTGCCAGCCATGAGTCCCAGGGTTCTGTGCCGTCACCC CTGGAGGCCCGAGTCAGCGAACCACTGCTCAGTGCCACCTCTGCATCCCCCACCCAGGTT GTGTCTCAACTTCCGATGGGCCGGGATTCCAGAGAAATGCTTTTCCTGGCAGAGCAGCCT CCTCTGCCTCCCCCACCTCTGCTGCCTCCCAGCCTCACCAATGGAACCACTATCCCCACT GCCAAGTCCACCCCCACACTCATTAAGCAAAGCCAACCCAAGTCTGCCAGTGAGAAGTCA CAGCGCAGCAAGAAGGCCAAGGAGCTGAAGCCAAAGGTGAAGAAGCTCAAGTACCACCAG TACATCCCCCCGGACCAGAAGCAGGACAGGGGGGCACCCCCCATGGACTCATCCTACGCC AAGATCCTGCAGCAGCAGCAGCTCTTCCTCCAGCTGCAGATCCTCAACCAGCAGCAGCAG CAGCACCACAACTACCAGGCCATCCTGCCTGCCCCGCCAAAGTCAGCAGGCGAGGCCCTG GGAAGCAGCGGGACCCCCCCAGTACGCAGCCTCTCCACTACCAATAGCAGCTCCAGCTCG GGCGCCCCTGGGCCCTGTGGGCTGGCACGTCAGAACAGCACCTCACTGACTGGCAAGCCG GGAGCCCTGCCGGCCAACCTGGACGACATGAAGGTGGCAGAGCTGAAGCAGGAGCTGAAG TTGCGATCACTGCCTGTCTCGGGCACCAAAACTGAGCTGATTGAGCGCCTTCGAGCCTAT CAAGACCAAATCAGCCCTGTGCCAGGAGCCCCCAAGGCCCCTGCCGCCACCTCTATCCTG CACAAGGCTGGCGAGGTGGTGGTAGCCTTCCCAGCGGCCCGGCTGAGCACGGGGCCAGCC CTGGTGGCAGCAGGCCTGGCTCCAGCTGAGGTGGTGGTGGCCACGGTGGCCAGCAGTGGG GTGGTGAAGTTTGGCAGCACGGGCTCCACGCCCCCCGTGTCTCCCACCCCCTCGGAGCGC TCACTGCTCAGCACGGGCGATGAAAACTCCACCCCCGGGGACACCTTTGGTGAGATGGTG ACATCACCTCTGACGCAGCTGACCCTGCAGGCCTCGCCACTGCAGATCCTCGTGAAGGAG GAGGGCCCCCGGGCCGGGTCCTGTTGCCTGAGCCCTGGGGGGCGGGCGGAGCTAGAGGGG CGCGACAAGGACCAGATGCTGCAGGAGAAAGACAAGCAGATCGAGGCGCTGACGCGCATG CTCCGGCAGAAGCAGCAGCTGGTGGAGCGGCTCAAGCTGCAGCTGGAGCAGGAGAAGCGA GCCCAGCAGCCCGCCCCCGCCCCCGCCCCCCTCGGCACCCCCGTGAAGCAGGAGAACAGC TTCTCCAGCTGCCAGCTGAGCCAGCAGCCCCTGGGCCCCGCTCACCCATTCAACCCCAGC CTGGCGGCCCCAGCCACCAACCACATAGACCCTTGTGCTGTGGCCCCGGGGCCCCCGTCC GTGGTGGTGAAGCAGGAAGCCTTGCAGCCTGAGCCCGAGCCGGTCCCCGCCCCCCAGTTG CTTCTGGGGCCTCAGGGCCCCAGCCTCATCAAGGGGGTTGCACCTCCCACCCTCATCACC GACTCCACAGGGACCCACCTTGTCCTCACCGTGACCAATAAGAATGCAGACAGCCCTGGC CTGTCCAGTGGGAGCCCCCAGCAGCCCTCGTCCCAGCCTGGCTCTCCAGCGCCTGCCCCC TCTGCCCAGATGGACCTGGAGCACCCACTGCAGCCCCTCTTTGGGACCCCCACTTCTCTG CTGAAGAAGGAACCACCTGGCTATGAGGAAGCCATGAGCCAGCAGCCCAAACAGCAGGAA AATGGTTCCTCAAGCCAGCAGATGGACGACCTGTTTGACATTCTCATTCAGAGCGGAGAA ATTTCAGCAGATTTCAAGGAGCCGCCATCCCTGCCAGGGAAGGAGAAGCCATCCCCGAAG ACAGTCTGTGGGTCCCCCCTGGCAGCACAGCCATCACCTTCTGCTGAGCTCCCCCAGGCT GCCCCACCTCCTCCAGGCTCACCCTCCCTCCCTGGACGCCTGGAGGACTTCCTGGAGAGC AGCACGGGGCTGCCCCTGCTGACCAGTGGGCATGACGGGCCAGAGCCCCTTTCCCTCATT GACGACCTCCATAGCCAGATGCTGAGCAGCACTGCCATCCTGGACCACCCCCCGTCACCC ATGGACACCTCGGAATTGCACTTTGTTCCTGAGCCCAGCAGCACCATGGGCCTGGACCTG GCTGATGGCCACCTGGACAGCATGGACTGGCTGGAGCTGTCGTCAGGTGGTCCCGTGCTG AGCCTAGCCCCCCTCAGCACCACAGCCCCCAGCCTCTTCTCCACAGACTTCCTCGATGGC CATGATTTGCAGCTGCACTGGGATTCCTGCTTGTAG
- Chromosome Location
- 22
- Locus
- 22q13
- External Identifiers
Resource Link UniProtKB ID Q969V6 UniProtKB Entry Name MKL1_HUMAN GenBank Protein ID 14041618 GenBank Gene ID AJ297257 HGNC ID HGNC:14334 - General References
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