Interstitial collagenase A
Details
- Name
- Interstitial collagenase A
- Synonyms
- 3.4.24.7
- Matrix metalloproteinase-1a
- Mcol-A
- McolA
- MMP-1a
- Gene Name
- Mmp1a
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052647|Interstitial collagenase A MPSLPLLLLLWAASSYSFPVFHNGDRQNVETVWKYLENYYNLGKNMQAKNVNGKEMMAEK LRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPDVAPYAITHNNPRWTKTHLTYSILNYTP YLPKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLSFHRGDHGDNNPFDGPNYKLAH TFQPGPGLGGDVHYDLDETWTNSSENFNLFYVTAHELGHSLGLTHSSDIGALMFPSYTWY TEDFVLNQDDINRIQDLYGPSPNPIQPTGATTPHPCNGDLTFDAITTFRGEVFFFKGRFY IRVNRFMPEPELNLIGILWPNLPVKLDAAYEASMIDQVRYFKGSKVWAVQEQSVLRGFPR DIHSFFGFPSNVTHIDAAVCEEETGKTYFFVDHMYWRYDENTQSMDPGYPRLTAEDFPGI DDKVDDVFQKGENFYFFHQSVQHRFNLQIRRVDDSRDSSTWFNC
- Number of residues
- 464
- Molecular Weight
- 53487.625
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetalloendopeptidase activity / serine-type endopeptidase activity / zinc ion bindingProcessescellular response to alkaloid / cellular response to drug / cellular response to fluid shear stress / cellular response to interleukin-1 / cellular response to iron(III) ion / cellular response to lipopolysaccharide / cellular response to peptide hormone stimulus / cellular response to tumor necrosis factor / cellular response to UV-A / cellular response to vitamin D / collagen catabolic process / extracellular matrix organization / luteinization / luteolysis / positive regulation of fibroblast migration / positive regulation of smooth muscle cell migration / response to inactivity / response to indole-3-methanol / response to mechanical stimulusComponentscytoplasm / extracellular matrix / extracellular space
- General Function
- Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (By similarity). Able to degrade synthetic peptides and type I and II fibrillar collagen.
- Specific Function
- Metalloendopeptidase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052648|Interstitial collagenase A (Mmp1a) ATGCCTAGCCTTCCTTTGCTGTTGCTTCTCTGGGCTGCTAGCTCATACAGTTTCCCTGTG TTTCACAACGGAGACCGGCAAAATGTGGAGACAGTCTGGAAATACCTGGAAAACTACTAC AACTTGGGCAAAAACATGCAAGCTAAAAACGTGAATGGCAAGGAGATGATGGCTGAAAAG CTGAGGCAAATGCAGCAGTTATTTGGGCTGAAAGTGACTGGAAATTCAGATCCTGAAACC CTGAGAGCTATGAAGAAGCCCAGGTGTGGGGTGCCTGATGTGGCCCCATATGCCATTACT CACAACAATCCTCGTTGGACCAAAACACATCTGACATACAGCATTTTAAACTACACACCA TATTTGCCAAAAGCAGTTGTGGAAGATGCCATCGCGAGAGCCTTTAGAGTCTGGAGTGAT GTGACACCACTTACGTTCCAAAGAGTCTTTGAGGAGGAAGGCGATATTGTGCTCTCCTTC CACAGAGGAGACCATGGTGACAACAACCCATTTGATGGACCTAACTATAAGCTTGCTCAC ACTTTCCAGCCAGGCCCAGGTTTGGGGGGTGATGTTCATTATGACCTTGATGAGACGTGG ACCAACAGCAGTGAAAATTTCAACTTGTTCTATGTTACGGCTCATGAACTGGGTCACTCC CTTGGGCTCACTCATTCTAGTGATATAGGAGCACTAATGTTCCCCAGTTACACGTGGTAC ACTGAAGACTTTGTGCTAAACCAGGATGATATTAATCGCATCCAGGACTTATATGGACCT TCCCCAAATCCCATCCAGCCAACAGGTGCAACAACACCACATCCATGTAATGGTGATCTA ACCTTTGATGCTATAACTACATTTAGGGGAGAGGTGTTTTTCTTCAAAGGCAGGTTCTAC ATTCGGGTAAATAGATTCATGCCAGAACCTGAGCTCAATTTAATAGGTATTCTCTGGCCA AATCTTCCAGTTAAACTTGACGCTGCTTATGAAGCTAGTATGATAGATCAAGTCCGCTAT TTCAAAGGCAGCAAAGTATGGGCTGTTCAAGAGCAGAGTGTACTGAGAGGATTCCCCAGA GACATCCACAGTTTCTTTGGCTTCCCTAGCAATGTGACACACATTGATGCTGCTGTTTGT GAGGAAGAGACTGGAAAAACATACTTCTTTGTTGACCACATGTACTGGAGGTATGATGAA AATACACAGTCTATGGATCCAGGTTATCCCAGATTAACAGCAGAAGACTTCCCTGGAATT GATGATAAAGTTGATGATGTTTTCCAAAAAGGAGAAAATTTCTATTTCTTTCACCAATCA GTTCAACACAGATTTAACCTCCAAATAAGAAGAGTTGATGATTCCCGTGATTCTAGTACA TGGTTCAACTGCTAA
- Chromosome Location
- 9
- Locus
- 9 A1
- External Identifiers
Resource Link UniProtKB ID Q9EPL5 UniProtKB Entry Name MMP1A_MOUSE - General References
- Balbin M, Fueyo A, Knauper V, Lopez JM, Alvarez J, Sanchez LM, Quesada V, Bordallo J, Murphy G, Lopez-Otin C: Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem. 2001 Mar 30;276(13):10253-62. doi: 10.1074/jbc.M009586200. Epub 2000 Dec 11. [Article]
- Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details