Tumor necrosis factor ligand superfamily member 13B
Details
- Name
- Tumor necrosis factor ligand superfamily member 13B
- Synonyms
- B lymphocyte stimulator
- B-cell-activating factor
- BAFF
- BLYS
- Dendritic cell-derived TNF-like molecule
- TALL-1
- TALL1
- TNF- and APOL-related leukocyte expressed ligand 1
- TNFSF20
- ZTNF4
- Gene Name
- TNFSF13B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001989|Tumor necrosis factor ligand superfamily member 13B MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
- Number of residues
- 285
- Molecular Weight
- 31222.48
- Theoretical pI
- 6.15
- GO Classification
- Functionsreceptor bindingProcessesB cell costimulation / B cell homeostasis / cell proliferation / immune response / immunoglobulin secretion / positive regulation of B cell proliferation / positive regulation of cell proliferation / positive regulation of germinal center formation / positive regulation of T cell proliferation / signal transduction / T cell costimulation / tumor necrosis factor-mediated signaling pathwayComponentscytoplasm / extracellular region / extracellular space / integral component of membrane / perinuclear region of cytoplasm / plasma membrane
- General Function
- Receptor binding
- Specific Function
- Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
- Pfam Domain Function
- TNF (PF00229)
- Transmembrane Regions
- 47-67
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010699|Tumor necrosis factor ligand superfamily member 13B (TNFSF13B) ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAA GAAATGAAACTGAAGGAGTGTGTTTCCATCCTCCCACGGAAGGAAAGCCCCTCTGTCCGA TCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGG GCAGAGCTGCAGGGCCACCACGCGGAGAAGCTGCCAGCAGGAGCAGGAGCCCCCAAGGCC GGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAA ACAGGATCTTACACATTTGTTCCATGGCTTCTCAGCTTTAAAAGGGGAAGTGCCCTAGAA GAAAAAGAGAATAAAATATTGGTCAAAGAAACTGGTTACTTTTTTATATATGGTCAGGTT TTATATACTGATAAGACCTACGCCATGGGACATCTAATTCAGAGGAAGAAGGTCCATGTC TTTGGGGATGAATTGAGTCTGGTGACTTTGTTTCGATGTATTCAAAATATGCCTGAAACA CTACCCAATAATTCCTGCTATTCAGCTGGCATTGCAAAACTGGAAGAAGGAGATGAACTC CAACTTGCAATACCAAGAGAAAATGCACAAATATCACTGGATGGAGATGTCACATTTTTT GGTGCATTGAAACTGCTGTGA
- Chromosome Location
- 13
- Locus
- 13q32-34
- External Identifiers
Resource Link UniProtKB ID Q9Y275 UniProtKB Entry Name TN13B_HUMAN GenBank Protein ID 4761612 GenBank Gene ID AF136293 GenAtlas ID TNFSF13B HGNC ID HGNC:11929 - General References
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