Protein unc-13 homolog B
Details
- Name
- Protein unc-13 homolog B
- Synonyms
- munc13
- Munc13-2
- Unc13a
- Gene Name
- Unc13b
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052401|Protein unc-13 homolog B MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTKNPTPHK ILLDTRFELPFDIPEEEARYWTYKLEQINALADDNEYSSQEESQRKPLPTAAAQCCHWTY LGWGEHQTFEDPDSAVDDRDSDYRSETSNSAPPPYHTTTQPNASVHQFPVPVRLPQQLFL QGSSHDSCNDSMQSYDLDYPERRALSPTSSSRYGSSCNVSQGSSLLSELDQYHEQDDDGR ERDSIHSSHSYGSLSKDGQAGLGEQEKALEVTCESEKEKTGESKEMRDDATIHPPSDLVL HKDHVLGPQESLPEETASSPFTQARAHWFRAVTKVRLQLQEISDDGDPSLPQWLPEGPAG GLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQAL IYPISCTTPHNFEVWSATTPTYCYECEGLLWGLARQGMRCSECGVKCHEKCQDLLNADCL QRAAEKSSKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVSKVAHVQQMKTVK QSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIFGNLNPVWE EKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYN LEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVWIPEA RGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANI NAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQ DLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSHQYQ LQEQPLEEPGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLSQFPQELNVGKVSAEVMWH LFAQDMKYALEEHEKDRLCKSADYMNLHFKVKWLHNEYVRDLPALQGQVPEYPAWFEQFV LQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECP DPNILAHYMRRFAKTIGKVLMQYADILSKNFPAYCTKERLPCILMNNMQQLRVQLEKMFE AMGGKELDSEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGN ASPNARASVAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERVIV LPPLTDQTGTQLILTAAKELSQLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAG GNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTAQGAGVDDPVGEVSIQVDL FTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWTP KYNETFHFLLGNEEGPEAYELQICVKDYCFAREDRVIGLAVMPLRDVAAKGSCACWCPLG RKIHMDETGMTILRILSQRSNDEVAREFVKLKSESRSTEEGS
- Number of residues
- 1602
- Molecular Weight
- 181811.505
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium ion binding / calmodulin binding / diacylglycerol binding / GTP-dependent protein binding / non-kinase phorbol ester receptor activity / phospholipid binding / syntaxin binding / syntaxin-1 bindingProcessesacrosomal vesicle exocytosis / cellular response to glucose stimulus / chemical synaptic transmission / dense core granule priming / innervation / intracellular signal transduction / negative regulation of synaptic plasticity / neuromuscular junction development / neuronal dense core vesicle exocytosis / phagosome maturation / positive regulation of apoptotic process / positive regulation of defense response to bacterium / positive regulation of exocytosis / positive regulation of inhibitory postsynaptic potential / positive regulation of protein secretion / positive regulation of synaptic vesicle priming / presynaptic dense core vesicle exocytosis / regulation of short-term neuronal synaptic plasticity / spontaneous neurotransmitter secretion / synaptic transmission, glutamatergic / synaptic vesicle docking / synaptic vesicle exocytosis / synaptic vesicle maturation / synaptic vesicle primingComponentscalyx of Held / cell / cell junction / cytosol / early phagosome / glutamatergic synapse / Golgi apparatus / hippocampal mossy fiber to CA3 synapse / membrane / neuromuscular junction / plasma membrane / presynapse / presynaptic active zone / presynaptic active zone cytoplasmic component / presynaptic membrane / ribbon synapse / synaptic membrane / synaptic vesicle membrane / terminal bouton
- General Function
- Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896).
- Specific Function
- Calcium ion binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052402|Protein unc-13 homolog B (Unc13b) ATGTCGCTGCTCTGTGTGCGTGTTAAAAGAGCCAAATTCCAGGGTTCACCAGATAAATTT AACACATATGTGACCCTGAAAGTCCAGAACGTGAAGAGCACAACTGTAGCAGTTCGTGGT GATCAGCCTTCCTGGGAGCAGGATTTCATGTTTGAGATCAGTCGTCTGGACCTGGGCCTA AGTGTGGAGGTGTGGAACAAGGGACTGATATGGGACACAATGGTGGGCACCGTGTGGATT GCACTGAAGACAATCCGTCAGTCGGATGAGGAAGGGCCCGGGGAGTGGTCTACACTGGAG GCAGAGACGTTAATGAAAGATGATGAGATCTGTGGAACTAAAAATCCAACTCCTCATAAA ATCTTGCTTGATACAAGATTTGAGCTGCCTTTTGACATCCCAGAGGAGGAAGCCAGATAT TGGACCTACAAATTGGAGCAAATCAATGCCTTGGCAGATGATAATGAGTATTCTAGTCAA GAAGAAAGCCAGAGGAAGCCATTACCCACTGCTGCCGCCCAGTGTTGTCACTGGACCTAT TTGGGCTGGGGAGAGCATCAGACCTTTGAAGACCCTGATAGTGCCGTTGATGACCGAGAC AGTGACTACCGCAGTGAGACCAGCAATAGCGCCCCACCTCCTTACCACACGACTACCCAG CCCAACGCTTCTGTACACCAGTTCCCTGTTCCTGTGCGGCTGCCACAGCAGCTCTTTCTT CAAGGCAGTTCCCATGACTCTTGCAATGACTCTATGCAGAGTTACGACCTTGATTATCCA GAGCGTCGGGCCCTCAGCCCTACCAGCAGTAGTAGGTATGGCTCCTCCTGTAATGTGAGT CAAGGAAGCTCTCTGCTGAGTGAGCTGGACCAGTATCATGAGCAAGATGATGATGGTCGG GAGAGGGACTCCATTCATTCTAGTCATAGCTATGGCAGCCTCTCCAAAGATGGCCAGGCT GGTTTGGGAGAACAAGAGAAAGCCTTGGAAGTGACATGTGAATCAGAAAAAGAGAAAACA GGTGAATCCAAGGAGATGAGAGATGATGCTACAATCCACCCTCCTTCAGATCTGGTGCTG CATAAGGACCATGTCCTAGGACCCCAGGAGAGTCTTCCTGAGGAGACCGCATCATCGCCA TTTACCCAGGCCAGAGCACACTGGTTCCGAGCGGTTACCAAGGTCCGACTCCAACTGCAG GAGATTTCAGATGATGGTGACCCCTCCTTGCCTCAGTGGCTCCCAGAAGGGCCAGCTGGA GGGCTCTATGGCATTGACAGCATGCCAGATCTACGAAGGAAGAAGCCACTGCCACTTGTC AGTGATCTGTCACTGGTCCAGTCACGGAAAGCTGGGATTACATCTGCTATGGCTACACGT ACCTCTCTCAAGGATGAAGAACTGAAATCTCATGTGTATAAGAAAACTCTGCAGGCCTTA ATCTACCCCATCTCGTGTACCACGCCCCACAACTTTGAGGTCTGGTCTGCCACTACACCT ACCTATTGCTATGAGTGTGAAGGCTTGCTCTGGGGCCTTGCCCGGCAAGGCATGCGCTGC AGCGAGTGTGGAGTCAAGTGCCATGAGAAGTGCCAGGACCTGCTCAATGCTGACTGCCTA CAGCGGGCTGCTGAAAAGAGCTCTAAGCATGGAGCTGAGGACCGAACTCAGAACATTATC ATGGCCATGAAGGACCGTATGAAGATCCGAGAACGGAATAAACCAGAGATCTTTGAGGTT ATCCGGGATGTGTTCACAGTGAGCAAAGTTGCGCATGTGCAGCAGATGAAAACAGTAAAG CAGAGTGTCCTGGATGGCACCTCCAAGTGGTCAGCCAAAATTACCATCACGGTGGTTTGT GCCCAGGGCCTACAAGCCAAAGACAAGACAGGATCCAGTGACCCTTATGTGACTGTGCAA GTTGGGAAAACCAAGAAGCGCACCAAGACCATTTTTGGAAATTTGAATCCTGTTTGGGAA GAGAAGTTCCATTTTGAGTGCCACAACTCTTCTGATCGAATTAAGGTACGCGTGTGGGAT GAGGATGATGACATCAAGTCCAGAGTAAAGCAGCGGCTAAAGCGAGAGTCAGATGATTTC CTTGGCCAAACTATCATTGAAGTTCGAACGCTGAGTGGAGAGATGGATGTCTGGTACAAT CTGGAGAAGAGAACAGACAAGTCAGCTGTCTCAGGGGCTATCCGACTTCAAATCAGTGTG GAGATCAAGGGGGAGGAGAAGGTAGCCCCATACCATGTACAATATACATGTCTCCATGAG AACCTTTTCCATTACCTCACAGACATTCAGGGCAGTGGAGGAGTCTGGATCCCAGAGGCT CGGGGGGACGATGCATGGAAGGTGTACTTTGATGAGACAGCCCAAGAAATTGTGGATGAA TTCGCTATGCGCTATGGCATCGAGTCCATTTATCAGGCCATGACGCACTTTGCATGTTTG TCATCCAAGTACATGTGTCCTGGTGTACCAGCCGTGATGAGCACCTTACTGGCCAACATC AATGCCTATTATGCTCACACAACTGCCTCCACTAACGTCTCTGCATCTGATCGTTTTGCA GCCTCCAACTTTGGTAAAGAAAGATTTGTAAAACTGCTGGACCAGCTACACAACTCACTG AGGATAGACCTCTCTACATACAGGAATAACTTTCCTGCTGGGAGCCCTGAGCGGCTTCAG GATTTAAAGTCTACAGTGGATTTGCTGACCAGCATTACTTTCTTCAGGATGAAGGTGCAA GAACTTCAGAGCCCTCCAAGAGCCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCTTG AACTCTACATATGAATACATCTTCAACAACTGCCATGACCTCTACAGTCACCAGTATCAG CTGCAGGAACAACCTCTAGAGGAACCAGGGCCCAGCATTCGGAACTTGGATTTCTGGCCC AAACTTATCACACTCATTGTTTCGATCATAGAGGAGGATAAGAATTCCTACACACCTGTT CTGAGCCAGTTTCCTCAGGAGTTGAACGTAGGAAAAGTCAGTGCAGAAGTGATGTGGCAT CTGTTTGCTCAAGACATGAAATATGCACTGGAGGAACACGAGAAAGACCGGCTGTGTAAG AGTGCTGACTACATGAACCTGCACTTCAAGGTGAAGTGGCTCCACAATGAATATGTGCGC GATCTGCCTGCCCTCCAGGGGCAAGTGCCTGAGTACCCAGCGTGGTTTGAGCAGTTTGTG CTACAGTGGCTAGATGAGAATGAAGATGTGTCACTGGAATTCCTTCGTGGGGCCTTGGAA CGAGATAAGAAGGATGGGTTCCAGCAGACATCAGAGCATGCCTTGTTTTCCTGTTCTGTG GTGGATGTCTTTACACAACTCAACCAGAGCTTTGAGATCATCCGGAAGTTGGAATGTCCA GACCCCAACATCCTTGCCCACTACATGAGAAGGTTTGCTAAGACCATTGGGAAAGTGCTG ATGCAGTATGCAGACATCTTATCAAAGAACTTCCCAGCTTACTGCACAAAGGAGAGACTG CCCTGTATCCTGATGAACAACATGCAGCAACTGAGGGTCCAGCTGGAGAAAATGTTTGAG GCCATGGGAGGCAAAGAGCTGGACTCCGAAGCTGCAGACAGTCTGAAGGAGCTGCAGGTG AAACTGAATACAGTTCTGGATGAGCTTAGCATGGTGTTTGGAAACAGCTTCCAGGTGCGG ATTGATGAATGTGTTCGACAAATGGCTGACATCCTGGGCCAAGTTCGGGGCACAGGGAAT GCATCCCCTAACGCCAGGGCCTCGGTGGCTCAGGATGCAGATAGTGTGCTGCGACCTCTC ATGGACTTCCTGGATGGCAACCTCACGCTGTTTGCCACTGTGTGTGAGAAGACAGTTCTG AAGCGGGTCCTGAAGGAGCTCTGGCGGGTGGTGATGAACACCATGGAGCGGGTTATTGTC CTGCCCCCACTCACTGACCAGACGGGCACCCAGCTGATCTTAACTGCTGCCAAGGAGCTG AGCCAGCTTTCCAAACTCAAGGACCACATGGTACGGGAGGAAACACGGAATCTCACTCCA AAGCAGTGTGCTGTCCTCGACTTGGCCTTGGACACCATCAAGCAATACTTCCATGCAGGA GGCAATGGTCTGAAGAAAACCTTCCTGGAAAAGAGCCCAGACCTGCAGTCTCTGCGTTAT GCCCTCTCTCTGTATACACAGACTACAGACACTCTCATCAAGACATTTGTGCGCTCACAG ACTGCCCAGGGGGCTGGTGTGGATGACCCCGTGGGAGAAGTCTCTATTCAGGTGGACTTA TTTACACATCCTGGCACTGGGGAGCATAAGGTCACAGTGAAAGTGGTAGCAGCCAATGAC CTCAAGTGGCAGACAGCGGGTATGTTCCGGCCTTTTGTGGAAGTGACCATGGTTGGCCCA CACCAAAGTGATAAGAAGAGGAAGTTCACAACCAAGTCTAAAAGTAACAACTGGACTCCC AAGTACAACGAGACGTTTCACTTCCTCCTGGGAAATGAAGAGGGTCCAGAGGCCTATGAA TTGCAGATCTGTGTGAAGGATTACTGCTTTGCCCGGGAGGATCGTGTGATAGGACTGGCA GTGATGCCCCTGAGGGATGTGGCAGCTAAGGGCAGCTGTGCCTGCTGGTGCCCACTGGGC CGGAAGATCCATATGGATGAGACAGGCATGACCATTCTCCGGATTCTGTCTCAGAGGAGC AATGACGAGGTAGCCCGAGAGTTCGTGAAGCTCAAATCAGAGTCTCGATCCACAGAGGAA GGGAGCTGA
- Chromosome Location
- 4
- Locus
- 4 A5
- External Identifiers
Resource Link UniProtKB ID Q9Z1N9 UniProtKB Entry Name UN13B_MOUSE - General References
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- van de Bospoort R, Farina M, Schmitz SK, de Jong A, de Wit H, Verhage M, Toonen RF: Munc13 controls the location and efficiency of dense-core vesicle release in neurons. J Cell Biol. 2012 Dec 10;199(6):883-91. doi: 10.1083/jcb.201208024. [Article]