Reaction: Tenofovir alafenamide to 1 product
- Reaction
- Reaction type
- hydrolysis
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Murakami E, Wang T, Park Y, Hao J, Lepist EI, Babusis D, Ray AS: Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy. Antimicrob Agents Chemother. 2015;59(6):3563-9. doi: 10.1128/AAC.00128-15. Epub 2015 Apr 13. [Article]
- European Medicines Agency Assessment Report: Tenofovir Alafenamide [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Lysosomal protective protein Not Available Not Available confirmed Liver carboxylesterase 1 Not Available Not Available confirmed