Reaction: Lumateperone to 1 product

Reaction
Lumateperone
DB06077
ICI200131
DBMET02943
Reaction type
reduction
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Vyas P, Hwang BJ, Brasic JR: An evaluation of lumateperone tosylate for the treatment of schizophrenia. Expert Opin Pharmacother. 2019 Nov 30:1-7. doi: 10.1080/14656566.2019.1695778. [Article]
  2. Vanover KE, Davis RE, Zhou Y, Ye W, Brasic JR, Gapasin L, Saillard J, Weingart M, Litman RE, Mates S, Wong DF: Dopamine D2 receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia. Neuropsychopharmacology. 2019 Feb;44(3):598-605. doi: 10.1038/s41386-018-0251-1. Epub 2018 Oct 26. [Article]
Comments
carbonyl side chain reduced to an alcohol
Enzymes
EnzymeKmVmaxRole
Aldo-keto reductase familyNot AvailableNot Availableconfirmed