Reaction: Roxadustat to 1 product
- Reaction
- Reaction type
- hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Hansson A, Thevis M, Cox H, Miller G, Eichner D, Bondesson U, Hedeland M: Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry. J Pharm Biomed Anal. 2017 Feb 5;134:228-236. doi: 10.1016/j.jpba.2016.11.041. Epub 2016 Nov 27. [Article]
- EMA Approved Drug Products: Evrenzo (roxadustat) oral tablets [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C8 Not Available Not Available implied UDP-glucuronosyltransferase 1-9 Not Available Not Available implied