Reaction: Tretinoin to 1 product
- Reaction
- Reaction type
- isomerization
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Marill J, Capron CC, Idres N, Chabot GG: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. Biochem Pharmacol. 2002 Mar 1;63(5):933-43. doi: 10.1016/s0006-2952(01)00925-x. [Article]
- Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003 Feb;4(1):1-10. doi: 10.2174/1389200033336900. [Article]
- Regazzi MB, Iacona I, Gervasutti C, Lazzarino M, Toma S: Clinical pharmacokinetics of tretinoin. Clin Pharmacokinet. 1997 May;32(5):382-402. doi: 10.2165/00003088-199732050-00004. [Article]
- FDA Approved Drug Products: VESANOID (tretinoin) capsules, for oral use [Link]
- Comments
- This reaction may be spontaneous or performed by isomerases.
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A7 Not Available Not Available implied Cytochrome P450 2C8 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 2B6 Not Available Not Available implied Cytochrome P450 2A6 Not Available Not Available implied
