Reaction: Momelotinib to 1 product
- Reaction
- Reaction type
- oxidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Zheng J, Xin Y, Zhang J, Subramanian R, Murray BP, Whitney JA, Warr MR, Ling J, Moorehead L, Kwan E, Hemenway J, Smith BJ, Silverman JA: Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development. Drug Metab Dispos. 2018 Mar;46(3):237-247. doi: 10.1124/dmd.117.078899. Epub 2018 Jan 8. [Article]
- FDA Approved Drug Products: OJJAARA (momelotinib) tablets, for oral use (September 2023) [Link]
- Comments
- The reaction is morpholine ring oxidation.
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 2C8 Not Available Not Available implied Cytochrome P450 2C19 Not Available Not Available implied Cytochrome P450 1A2 Not Available Not Available implied Cytochrome P450 2C9 Not Available Not Available implied
