Reaction: Momelotinib to 1 product

Reaction
Momelotinib
DB11763
    Momelotinib M15 metabolite
    DBMET03715
    Reaction type
    hydrolysis
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Zheng J, Xin Y, Zhang J, Subramanian R, Murray BP, Whitney JA, Warr MR, Ling J, Moorehead L, Kwan E, Hemenway J, Smith BJ, Silverman JA: Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development. Drug Metab Dispos. 2018 Mar;46(3):237-247. doi: 10.1124/dmd.117.078899. Epub 2018 Jan 8. [Article]
    Comments
    Not Available
    Enzymes
    Not Available