Reaction: Copanlisib to 2 products

Reaction
Copanlisib
DB12483
Copanlisib M15 metabolite
DBMET03734
Copanlisib M2 metabolite
DBMET03735
Reaction type
dealkylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Gerisch M, Schwarz T, Lang D, Rohde G, Reif S, Genvresse I, Reschke S, van der Mey D, Granvil C: Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [(14)C]copanlisib (BAY 80-6946) in a mass balance study in healthy male volunteers. Cancer Chemother Pharmacol. 2017 Sep;80(3):535-544. doi: 10.1007/s00280-017-3383-9. Epub 2017 Jul 11. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied