Reaction: Bosutinib to 1 product

Reaction
Bosutinib
DB06616
N-desmethylbosutinib
DBMET03736
Reaction type
demethylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Abbas R, Hsyu PH: Clinical Pharmacokinetics and Pharmacodynamics of Bosutinib. Clin Pharmacokinet. 2016 Oct;55(10):1191-1204. doi: 10.1007/s40262-016-0391-6. [Article]
  2. Breccia M, Binotto G: Bosutinib for Chronic Myeloid Leukemia. Rare Cancers Ther. 2015;3(1):35-46. doi: 10.1007/s40487-015-0010-y. Epub 2015 Aug 26. [Article]
  3. FDA Approved Drug Products: BOSULIF® (bosutinib) tablets/capsules, for oral use (October 2023) [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed