Seproxetine hydrochlorideProduct ingredient for Seproxetine
- Name
- Seproxetine hydrochloride
- Drug Entry
- Seproxetine
Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
- Accession Number
- DBSALT000562
- Structure
Structure for Seproxetine hydrochloride (DBSALT000562)
- Synonyms
- Seproxetine HCl
- UNII
- K4QYN23H2N
- CAS Number
- 127685-30-7
- Weight
- Average: 331.76
Monoisotopic: 331.0950764 - Chemical Formula
- C16H17ClF3NO
- InChI Key
- GMTWWEPBGGXBTO-RSAXXLAASA-N
- InChI
- InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H/t15-;/m0./s1
- IUPAC Name
- (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride
- SMILES
- Cl.NCC[C@H](OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
- External Links
- PubChem Compound
- 4541
- ChemSpider
- 2319850
- ChEMBL
- CHEMBL2107550
- Predicted Properties
Property Value Source Water Solubility 0.00915 mg/mL ALOGPS logP 3.8 ALOGPS logP 3.74 Chemaxon logS -4.5 ALOGPS pKa (Strongest Basic) 9.77 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 35.25 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 75.59 m3·mol-1 Chemaxon Polarizability 28.15 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon