Ceftizoxime sodiumProduct ingredient for Ceftizoxime
- Name
- Ceftizoxime sodium
- Drug Entry
- Ceftizoxime
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
- Accession Number
- DBSALT001162
- Structure
- Synonyms
- Not Available
- UNII
- 26337D5X88
- CAS Number
- 68401-82-1
- Weight
- Average: 405.38
Monoisotopic: 405.01775513 - Chemical Formula
- C13H12N5NaO5S2
- InChI Key
- ADLFUPFRVXCDMO-LIGXYSTNSA-M
- InChI
- InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
- IUPAC Name
- sodium (2Z)-N-[(6R,7R)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethanecarboximidate
- SMILES
- [Na+].[H][C@]12SCC=C(N1C(=O)[C@@]2([H])N=C([O-])C(=N/OC)\C1=CSC(=N)N1)C(O)=O
- External Links
- KEGG Compound
- C08118
- ChemSpider
- 7962928
- ChEBI
- 3512
- ChEMBL
- CHEMBL1201019
- Wikipedia
- Ceftizoxime
- Predicted Properties
Property Value Source Water Solubility 0.295 mg/mL ALOGPS logP 1.02 ALOGPS logP 0.7 Chemaxon logS -3.1 ALOGPS pKa (Strongest Acidic) 3.29 Chemaxon pKa (Strongest Basic) 0.72 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 150.5 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 113.76 m3·mol-1 Chemaxon Polarizability 35.59 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon